Metronomic chemotherapy offsets HIFα induction upon maximum‐tolerated dose in metastatic cancers

Metronomic chemotherapy offsets HIFα induction upon maximum‐tolerated dose in metastatic cancers

Abstract Conventional maximum‐tolerated dose (MTD) chemotherapy relies on periodic, massive cancer cell ablation events followed by treatment‐free intermissions, stereotypically resulting in resistance, relapse, and mortality. Furthermore, MTD chemotherapy can promote metastatic dissemination via ac...

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Bibliographic Details
Main Authors: Luana Schito, Sergio Rey, Ping Xu, Shan Man, William Cruz‐Muñoz, Robert S Kerbel
Format: Article
Language:English
Published: Springer Nature 2020-07-01
Series:EMBO Molecular Medicine
Subjects:
breast cancer
colon cancer
HIF‐1
hypoxia
low‐dose metronomic
Online Access:https://doi.org/10.15252/emmm.201911416

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