Impact of FHIT loss on the translation of cancer-associated mRNAs

Impact of FHIT loss on the translation of cancer-associated mRNAs

Abstract Background FHIT is a genome caretaker/tumor suppressor that is silenced in >50% of cancers. Although it was identified more than 20 years ago, questions remain as to how FHIT loss contributes to cancer, and conversely, how FHIT acts to maintain genome integrity and suppress malignancy. F...

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Bibliographic Details
Main Authors: Daniel L. Kiss, William Baez, Kay Huebner, Ralf Bundschuh, Daniel R. Schoenberg
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Molecular Cancer
Subjects:
Fhit
Translational control
Ribosome profiling
Scavenger decapping
Gene expression
Online Access:http://link.springer.com/article/10.1186/s12943-017-0749-x

Internet

http://link.springer.com/article/10.1186/s12943-017-0749-x

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