Misclassification of Gleason grade and tumor stage in Asian‐American patients with low‐risk prostate cancer
Abstract To investigate the misclassification rates of Asian‐American patients with low‐risk prostate cancer (PCa). Patients diagnosed with low‐risk PCa treated with radical prostatectomy between 2010 and 2015 in the Surveillance, Epidemiology, and End Results database were included in this study. T...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Precision Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/prm2.12098 |
| _version_ | 1797809957415944192 |
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| author | Lu Li Yihang Xu Zicheng Xu Feng Qi Xiao Li |
| author_facet | Lu Li Yihang Xu Zicheng Xu Feng Qi Xiao Li |
| author_sort | Lu Li |
| collection | DOAJ |
| description | Abstract To investigate the misclassification rates of Asian‐American patients with low‐risk prostate cancer (PCa). Patients diagnosed with low‐risk PCa treated with radical prostatectomy between 2010 and 2015 in the Surveillance, Epidemiology, and End Results database were included in this study. Then, basic characteristics and pathological outcomes of the enrolled patients were retrospectively extracted. We compared the rates of upgrading and/or upstaging between Asian‐American patients and White/Black patients. Moreover, temporal trend analyses were performed to explore the changes in upgrading and upstaging rates in each race over time. Finally, logistic regression models were constructed to explore the role of Asian race in upgrading and upstaging and to screen out potential risk factors for predicting upgrading and upstaging in Asian‐American patients. Asian‐Americans had a significantly higher rate of upgrading than Whites (P < .001), while no statistical difference was found in the comparison of upstaging rate (P = .536). Moreover, Asian‐Americans were more likely to upgrade to diseases with higher ISUP grade than Whites (P = .010). The rate of upgrading increased significantly over time in White and Black patients, but not in Asian‐American patients. Finally, race seemed to be an independent risk factor for predicting upgrading, while the racial differences seemed to be more pronounced between White and Black patients. Asian‐American patients had a significantly higher rate of upgrading than White patients. Moreover, Asian‐American patients were more likely to upgrade to diseases with higher ISUP grade. Further risk assessment before clinical decision for low‐risk PCa patients with the help of significant clinical variables is required. |
| first_indexed | 2024-03-13T07:00:47Z |
| format | Article |
| id | doaj.art-0b3ef6ad9fd044768053f8eadedebd31 |
| institution | Directory Open Access Journal |
| issn | 2642-2514 |
| language | English |
| last_indexed | 2024-03-13T07:00:47Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Precision Medical Sciences |
| spelling | doaj.art-0b3ef6ad9fd044768053f8eadedebd312023-06-06T22:32:51ZengWileyPrecision Medical Sciences2642-25142023-06-011229510310.1002/prm2.12098Misclassification of Gleason grade and tumor stage in Asian‐American patients with low‐risk prostate cancerLu Li0Yihang Xu1Zicheng Xu2Feng Qi3Xiao Li4Student of Nanjing Medical University Nanjing ChinaStudent of The First Clinical Medical College of Nanjing Medical University Nanjing ChinaDepartment of Urologic Surgery Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaDepartment of Urologic Surgery Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaDepartment of Urologic Surgery Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaAbstract To investigate the misclassification rates of Asian‐American patients with low‐risk prostate cancer (PCa). Patients diagnosed with low‐risk PCa treated with radical prostatectomy between 2010 and 2015 in the Surveillance, Epidemiology, and End Results database were included in this study. Then, basic characteristics and pathological outcomes of the enrolled patients were retrospectively extracted. We compared the rates of upgrading and/or upstaging between Asian‐American patients and White/Black patients. Moreover, temporal trend analyses were performed to explore the changes in upgrading and upstaging rates in each race over time. Finally, logistic regression models were constructed to explore the role of Asian race in upgrading and upstaging and to screen out potential risk factors for predicting upgrading and upstaging in Asian‐American patients. Asian‐Americans had a significantly higher rate of upgrading than Whites (P < .001), while no statistical difference was found in the comparison of upstaging rate (P = .536). Moreover, Asian‐Americans were more likely to upgrade to diseases with higher ISUP grade than Whites (P = .010). The rate of upgrading increased significantly over time in White and Black patients, but not in Asian‐American patients. Finally, race seemed to be an independent risk factor for predicting upgrading, while the racial differences seemed to be more pronounced between White and Black patients. Asian‐American patients had a significantly higher rate of upgrading than White patients. Moreover, Asian‐American patients were more likely to upgrade to diseases with higher ISUP grade. Further risk assessment before clinical decision for low‐risk PCa patients with the help of significant clinical variables is required.https://doi.org/10.1002/prm2.12098Asian Americanlow‐riskmisclassificationprostate cancerSEER |
| spellingShingle | Lu Li Yihang Xu Zicheng Xu Feng Qi Xiao Li Misclassification of Gleason grade and tumor stage in Asian‐American patients with low‐risk prostate cancer Precision Medical Sciences Asian American low‐risk misclassification prostate cancer SEER |
| title | Misclassification of Gleason grade and tumor stage in Asian‐American patients with low‐risk prostate cancer |
| title_full | Misclassification of Gleason grade and tumor stage in Asian‐American patients with low‐risk prostate cancer |
| title_fullStr | Misclassification of Gleason grade and tumor stage in Asian‐American patients with low‐risk prostate cancer |
| title_full_unstemmed | Misclassification of Gleason grade and tumor stage in Asian‐American patients with low‐risk prostate cancer |
| title_short | Misclassification of Gleason grade and tumor stage in Asian‐American patients with low‐risk prostate cancer |
| title_sort | misclassification of gleason grade and tumor stage in asian american patients with low risk prostate cancer |
| topic | Asian American low‐risk misclassification prostate cancer SEER |
| url | https://doi.org/10.1002/prm2.12098 |
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