A comparative evaluation of apoptotic and mitotic indexes in lichen planus, lichenoid lesion and squamous cell carcinoma of the oral cavity by Hematoxylin and Eosin staining
Background and Aim: Oral lichen planus (OLP) and oral lichenoid lesion(OLL) are suggested as premalignant lesions capable of transforming into oral squamous cell carcinoma (OSCC). However, their malignant potential is a matter of controversy. Since alterations in the cell proliferation and apoptosis...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Kurdistan University of Medical Sciences
2022-01-01
|
| Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
| Subjects: | |
| Online Access: | http://sjku.muk.ac.ir/article-1-5751-en.html |
| _version_ | 1818535432992849920 |
|---|---|
| author | Mahsa Bayati Massoumeh Zargaran Abbas Moghimbeigi |
| author_facet | Mahsa Bayati Massoumeh Zargaran Abbas Moghimbeigi |
| author_sort | Mahsa Bayati |
| collection | DOAJ |
| description | Background and Aim: Oral lichen planus (OLP) and oral lichenoid lesion(OLL) are suggested as premalignant lesions capable of transforming into oral squamous cell carcinoma (OSCC). However, their malignant potential is a matter of controversy. Since alterations in the cell proliferation and apoptosis are indicators of malignant transformation the aim of this study was to investigate apoptotic and mitotic indexes in lichen planus, lichenoid lesion and squamous cell carcinoma of the oral cavity by using Hematoxylin and Eosin (H&E) staining.
Material and Method: Apoptotic index (AI) and mitotic index (MI) were determined in H&E slides of 20 cases of epithelial hyperplasia (group A), 29 cases of OLP (group B), 13 cases of OLL (group C) and 28 cases of OSCC (group D).
Results: There was a significant difference in AI and MI among the four groups (p˂0.001). Pairwise comparison of the groups showed only insignificant difference in AI between group B and groups C(P=0.52). There was no significant difference in MI between group B and group C, between group B and group A as well as between group C and group A (p>0.05).
Conclusion: The results of the present study revealed that apoptotic and mitotic indexes in OLP and OLL were significantly less than that of OSCC possibly due to the different nature of OLP and OLL. Although, it seems that these results did not indicate occurrence of malignant transformation in OLP and OLL. Further and more comprehensive studies are required to reach a definitive conclusion in this regard.Material and Method: Apoptotic indexe (AI) and mitotic indexe (MI) were determined in H&E slides belong to 20 cases of epithelial hyperplasia (A group), 29 cases of OLP (B group), 13 cases of OLL (C group) and 28 cases of OSCC (D group).
Results: There was a significant difference in AI and MI among the four studied groups (p˂0.001). In bilaterally comparison of groups; AI difference between two groups of B and C(P=0.52) was insignificant merely. Additionally, MI difference between groups of B and C, between B and A as well as between C and A (p>0.05) were insignificant.
Conclusion: The results of the present study revealed that apoptotic and mitotic indexes in OLP and OLL were significantly less than that of OSCC possibly due to different nature of these two lesions from OSCC. Although, it seems that these results do not suggest a malignant transformation in OLP and OLL further and more comprehensive studies are required for a definitive conclusion in this regard. |
| first_indexed | 2024-12-11T18:24:48Z |
| format | Article |
| id | doaj.art-0b3fd12892f34b4a8b35553693c4cee5 |
| institution | Directory Open Access Journal |
| issn | 1560-652X 2345-4040 |
| language | fas |
| last_indexed | 2024-12-11T18:24:48Z |
| publishDate | 2022-01-01 |
| publisher | Kurdistan University of Medical Sciences |
| record_format | Article |
| series | مجله علمی دانشگاه علوم پزشکی کردستان |
| spelling | doaj.art-0b3fd12892f34b4a8b35553693c4cee52022-12-22T00:55:08ZfasKurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان1560-652X2345-40402022-01-012678696A comparative evaluation of apoptotic and mitotic indexes in lichen planus, lichenoid lesion and squamous cell carcinoma of the oral cavity by Hematoxylin and Eosin stainingMahsa Bayati0Massoumeh Zargaran1Abbas Moghimbeigi2 Student of Dentistry, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran Associate Professor, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Kurdistan University of Medical Sciences, Sanandaj, Iran Professor, Department of Biostatistics and Epidemiology, School of Health, Alborz University of Medical Sciences, Karaj, Iran Background and Aim: Oral lichen planus (OLP) and oral lichenoid lesion(OLL) are suggested as premalignant lesions capable of transforming into oral squamous cell carcinoma (OSCC). However, their malignant potential is a matter of controversy. Since alterations in the cell proliferation and apoptosis are indicators of malignant transformation the aim of this study was to investigate apoptotic and mitotic indexes in lichen planus, lichenoid lesion and squamous cell carcinoma of the oral cavity by using Hematoxylin and Eosin (H&E) staining. Material and Method: Apoptotic index (AI) and mitotic index (MI) were determined in H&E slides of 20 cases of epithelial hyperplasia (group A), 29 cases of OLP (group B), 13 cases of OLL (group C) and 28 cases of OSCC (group D). Results: There was a significant difference in AI and MI among the four groups (p˂0.001). Pairwise comparison of the groups showed only insignificant difference in AI between group B and groups C(P=0.52). There was no significant difference in MI between group B and group C, between group B and group A as well as between group C and group A (p>0.05). Conclusion: The results of the present study revealed that apoptotic and mitotic indexes in OLP and OLL were significantly less than that of OSCC possibly due to the different nature of OLP and OLL. Although, it seems that these results did not indicate occurrence of malignant transformation in OLP and OLL. Further and more comprehensive studies are required to reach a definitive conclusion in this regard.Material and Method: Apoptotic indexe (AI) and mitotic indexe (MI) were determined in H&E slides belong to 20 cases of epithelial hyperplasia (A group), 29 cases of OLP (B group), 13 cases of OLL (C group) and 28 cases of OSCC (D group). Results: There was a significant difference in AI and MI among the four studied groups (p˂0.001). In bilaterally comparison of groups; AI difference between two groups of B and C(P=0.52) was insignificant merely. Additionally, MI difference between groups of B and C, between B and A as well as between C and A (p>0.05) were insignificant. Conclusion: The results of the present study revealed that apoptotic and mitotic indexes in OLP and OLL were significantly less than that of OSCC possibly due to different nature of these two lesions from OSCC. Although, it seems that these results do not suggest a malignant transformation in OLP and OLL further and more comprehensive studies are required for a definitive conclusion in this regard.http://sjku.muk.ac.ir/article-1-5751-en.htmlhematoxylin-eosinapoptosismitosisoral lichen planusoral squamous cellcoral lichenoid lesion |
| spellingShingle | Mahsa Bayati Massoumeh Zargaran Abbas Moghimbeigi A comparative evaluation of apoptotic and mitotic indexes in lichen planus, lichenoid lesion and squamous cell carcinoma of the oral cavity by Hematoxylin and Eosin staining مجله علمی دانشگاه علوم پزشکی کردستان hematoxylin-eosin apoptosis mitosis oral lichen planus oral squamous cellc oral lichenoid lesion |
| title | A comparative evaluation of apoptotic and mitotic indexes in lichen planus, lichenoid lesion and squamous cell carcinoma of the oral cavity by Hematoxylin and Eosin staining |
| title_full | A comparative evaluation of apoptotic and mitotic indexes in lichen planus, lichenoid lesion and squamous cell carcinoma of the oral cavity by Hematoxylin and Eosin staining |
| title_fullStr | A comparative evaluation of apoptotic and mitotic indexes in lichen planus, lichenoid lesion and squamous cell carcinoma of the oral cavity by Hematoxylin and Eosin staining |
| title_full_unstemmed | A comparative evaluation of apoptotic and mitotic indexes in lichen planus, lichenoid lesion and squamous cell carcinoma of the oral cavity by Hematoxylin and Eosin staining |
| title_short | A comparative evaluation of apoptotic and mitotic indexes in lichen planus, lichenoid lesion and squamous cell carcinoma of the oral cavity by Hematoxylin and Eosin staining |
| title_sort | comparative evaluation of apoptotic and mitotic indexes in lichen planus lichenoid lesion and squamous cell carcinoma of the oral cavity by hematoxylin and eosin staining |
| topic | hematoxylin-eosin apoptosis mitosis oral lichen planus oral squamous cellc oral lichenoid lesion |
| url | http://sjku.muk.ac.ir/article-1-5751-en.html |
| work_keys_str_mv | AT mahsabayati acomparativeevaluationofapoptoticandmitoticindexesinlichenplanuslichenoidlesionandsquamouscellcarcinomaoftheoralcavitybyhematoxylinandeosinstaining AT massoumehzargaran acomparativeevaluationofapoptoticandmitoticindexesinlichenplanuslichenoidlesionandsquamouscellcarcinomaoftheoralcavitybyhematoxylinandeosinstaining AT abbasmoghimbeigi acomparativeevaluationofapoptoticandmitoticindexesinlichenplanuslichenoidlesionandsquamouscellcarcinomaoftheoralcavitybyhematoxylinandeosinstaining AT mahsabayati comparativeevaluationofapoptoticandmitoticindexesinlichenplanuslichenoidlesionandsquamouscellcarcinomaoftheoralcavitybyhematoxylinandeosinstaining AT massoumehzargaran comparativeevaluationofapoptoticandmitoticindexesinlichenplanuslichenoidlesionandsquamouscellcarcinomaoftheoralcavitybyhematoxylinandeosinstaining AT abbasmoghimbeigi comparativeevaluationofapoptoticandmitoticindexesinlichenplanuslichenoidlesionandsquamouscellcarcinomaoftheoralcavitybyhematoxylinandeosinstaining |