Impact of Apolipoprotein B on Hepatosteatosis in a Population Infected with Hepatitis C Virus: A Cross-Sectional Observational Study
Objective: Non-alcoholic fatty liver disease (NAFLD) is an established risk factor for diabetes, cardiovascular disease, antiviral treatment resistance, and progression of chronic hepatitis C virus (HCV) infection to fibrosis. Apolipoprotein-B 100 (ApoB-100) is a dyslipidemia marker and steatosis pr...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2016-04-01
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| Series: | Obesity Facts |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/443692 |
| _version_ | 1818412929300561920 |
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| author | Ming-Shyan Lin Su-Er Guo Huang-Shen Lin Jen-Te Hsu Yu-Sheng Lin Tsai-Hui Lin Tung-Jung Huang Mei-Yen Chen Chang-Min Chung |
| author_facet | Ming-Shyan Lin Su-Er Guo Huang-Shen Lin Jen-Te Hsu Yu-Sheng Lin Tsai-Hui Lin Tung-Jung Huang Mei-Yen Chen Chang-Min Chung |
| author_sort | Ming-Shyan Lin |
| collection | DOAJ |
| description | Objective: Non-alcoholic fatty liver disease (NAFLD) is an established risk factor for diabetes, cardiovascular disease, antiviral treatment resistance, and progression of chronic hepatitis C virus (HCV) infection to fibrosis. Apolipoprotein-B 100 (ApoB-100) is a dyslipidemia marker and steatosis predictor. We assess the correlation between ApoB-100 and hepatosteatosis. Methods: This cross-sectional study enrolled 1,218 HCV-seropositive participants from a 2012-2013 health checkup in Taiwan. NAFLD was detected using ultrasound. All anthropometric and laboratory studies that included ApoB-100 were evaluated whether or not ApoB-100 predicts NAFLD. Logistic regression was also used to examine the association between ApoB-100 and NAFLD. Results: Participants were 47.16 ± 16.08 years old (mean age). The overall prevalence of NAFLD was 35.8% (n = 436; 32.8% men, 38.1% women). Participants with ApoB-100 ≥ 8 had a significantly higher incidence of NAFLD (39.4 vs. 29.4%; 95% CI 0.044-0.156; p Conclusion: ApoB-100 is strongly associated with NAFLD in people with non-genotype 3 HCV; greater ApoB-100 content is significantly correlated with higher-grade hepatosteatosis. |
| first_indexed | 2024-12-14T10:55:07Z |
| format | Article |
| id | doaj.art-0b4030dde9a24b01870b293e0faf3efe |
| institution | Directory Open Access Journal |
| issn | 1662-4025 1662-4033 |
| language | English |
| last_indexed | 2024-12-14T10:55:07Z |
| publishDate | 2016-04-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Obesity Facts |
| spelling | doaj.art-0b4030dde9a24b01870b293e0faf3efe2022-12-21T23:04:58ZengKarger PublishersObesity Facts1662-40251662-40332016-04-019210111110.1159/000443692443692Impact of Apolipoprotein B on Hepatosteatosis in a Population Infected with Hepatitis C Virus: A Cross-Sectional Observational StudyMing-Shyan LinSu-Er GuoHuang-Shen LinJen-Te HsuYu-Sheng LinTsai-Hui LinTung-Jung HuangMei-Yen ChenChang-Min ChungObjective: Non-alcoholic fatty liver disease (NAFLD) is an established risk factor for diabetes, cardiovascular disease, antiviral treatment resistance, and progression of chronic hepatitis C virus (HCV) infection to fibrosis. Apolipoprotein-B 100 (ApoB-100) is a dyslipidemia marker and steatosis predictor. We assess the correlation between ApoB-100 and hepatosteatosis. Methods: This cross-sectional study enrolled 1,218 HCV-seropositive participants from a 2012-2013 health checkup in Taiwan. NAFLD was detected using ultrasound. All anthropometric and laboratory studies that included ApoB-100 were evaluated whether or not ApoB-100 predicts NAFLD. Logistic regression was also used to examine the association between ApoB-100 and NAFLD. Results: Participants were 47.16 ± 16.08 years old (mean age). The overall prevalence of NAFLD was 35.8% (n = 436; 32.8% men, 38.1% women). Participants with ApoB-100 ≥ 8 had a significantly higher incidence of NAFLD (39.4 vs. 29.4%; 95% CI 0.044-0.156; p Conclusion: ApoB-100 is strongly associated with NAFLD in people with non-genotype 3 HCV; greater ApoB-100 content is significantly correlated with higher-grade hepatosteatosis.http://www.karger.com/Article/FullText/443692Hepatitis C virusApolipoprotein-BNon-alcoholic fatty liver disease |
| spellingShingle | Ming-Shyan Lin Su-Er Guo Huang-Shen Lin Jen-Te Hsu Yu-Sheng Lin Tsai-Hui Lin Tung-Jung Huang Mei-Yen Chen Chang-Min Chung Impact of Apolipoprotein B on Hepatosteatosis in a Population Infected with Hepatitis C Virus: A Cross-Sectional Observational Study Obesity Facts Hepatitis C virus Apolipoprotein-B Non-alcoholic fatty liver disease |
| title | Impact of Apolipoprotein B on Hepatosteatosis in a Population Infected with Hepatitis C Virus: A Cross-Sectional Observational Study |
| title_full | Impact of Apolipoprotein B on Hepatosteatosis in a Population Infected with Hepatitis C Virus: A Cross-Sectional Observational Study |
| title_fullStr | Impact of Apolipoprotein B on Hepatosteatosis in a Population Infected with Hepatitis C Virus: A Cross-Sectional Observational Study |
| title_full_unstemmed | Impact of Apolipoprotein B on Hepatosteatosis in a Population Infected with Hepatitis C Virus: A Cross-Sectional Observational Study |
| title_short | Impact of Apolipoprotein B on Hepatosteatosis in a Population Infected with Hepatitis C Virus: A Cross-Sectional Observational Study |
| title_sort | impact of apolipoprotein b on hepatosteatosis in a population infected with hepatitis c virus a cross sectional observational study |
| topic | Hepatitis C virus Apolipoprotein-B Non-alcoholic fatty liver disease |
| url | http://www.karger.com/Article/FullText/443692 |
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