MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation Mice
When facing stressful conditions, some people tend to be impulsively aggressive whereas others are not. However, the causes and underlying mechanisms remain elusive. It has been reported that acute stress induces outbursts of aggression in post-weaning social isolation (SI) mice but not in group hou...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S216225312030127X |
| _version_ | 1818598808842403840 |
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| author | Chih-Hua Chang Elizabeth Joo Wen Kuek Chun-Lin Su Po-Wu Gean |
| author_facet | Chih-Hua Chang Elizabeth Joo Wen Kuek Chun-Lin Su Po-Wu Gean |
| author_sort | Chih-Hua Chang |
| collection | DOAJ |
| description | When facing stressful conditions, some people tend to be impulsively aggressive whereas others are not. However, the causes and underlying mechanisms remain elusive. It has been reported that acute stress induces outbursts of aggression in post-weaning social isolation (SI) mice but not in group housing (GH) mice. Here we report epigenetic regulation of impulsive aggression in SI mice. At post-natal day 21, mice were randomly assigned to GH or SI groups. We found that SI mice exhibited a higher level of microRNA 206 (miR-206) compared with GH mice. Intra-hippocampal injection of AM206, an antagomir of miR-206, decreased stress-induced attack behavior in SI mice and increased BDNF expression. Moreover, BDNF expression was required for AM206 effects on the reduction of aggression. On the other hand, miR-206 overexpression in GH mice induced attack behavior. Intranasal administration of AM206 rather than a scramble control significantly reduced attack behavior and depression-like behavior in SI mice. Our results suggest that miR-206 mediates development of maladaptive impulsive aggression in early life adversity and that its antagomir could potentially be a therapeutic target against stress-exacerbated aggressive behavior. |
| first_indexed | 2024-12-16T12:09:35Z |
| format | Article |
| id | doaj.art-0b407ede413348c3acd5952dabe80e67 |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-12-16T12:09:35Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-0b407ede413348c3acd5952dabe80e672022-12-21T22:32:13ZengElsevierMolecular Therapy: Nucleic Acids2162-25312020-06-0120812822MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation MiceChih-Hua Chang0Elizabeth Joo Wen Kuek1Chun-Lin Su2Po-Wu Gean3Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan 701, Taiwan; Department of Biotechnology and Bioindustry Sciences, National Cheng-Kung University, Tainan 701, TaiwanDepartment of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan 701, TaiwanDivision of Natural Sciences, Center for General Education, Southern Taiwan University of Science and Technology, Tainan 710, TaiwanDepartment of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan 701, Taiwan; Department of Biotechnology and Bioindustry Sciences, National Cheng-Kung University, Tainan 701, Taiwan; Corresponding author: Po-Wu Gean, Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan 701, Taiwan.When facing stressful conditions, some people tend to be impulsively aggressive whereas others are not. However, the causes and underlying mechanisms remain elusive. It has been reported that acute stress induces outbursts of aggression in post-weaning social isolation (SI) mice but not in group housing (GH) mice. Here we report epigenetic regulation of impulsive aggression in SI mice. At post-natal day 21, mice were randomly assigned to GH or SI groups. We found that SI mice exhibited a higher level of microRNA 206 (miR-206) compared with GH mice. Intra-hippocampal injection of AM206, an antagomir of miR-206, decreased stress-induced attack behavior in SI mice and increased BDNF expression. Moreover, BDNF expression was required for AM206 effects on the reduction of aggression. On the other hand, miR-206 overexpression in GH mice induced attack behavior. Intranasal administration of AM206 rather than a scramble control significantly reduced attack behavior and depression-like behavior in SI mice. Our results suggest that miR-206 mediates development of maladaptive impulsive aggression in early life adversity and that its antagomir could potentially be a therapeutic target against stress-exacerbated aggressive behavior.http://www.sciencedirect.com/science/article/pii/S216225312030127XepigeneticsmicroRNAmiR-206aggressionsocial isolationBDNF |
| spellingShingle | Chih-Hua Chang Elizabeth Joo Wen Kuek Chun-Lin Su Po-Wu Gean MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation Mice Molecular Therapy: Nucleic Acids epigenetics microRNA miR-206 aggression social isolation BDNF |
| title | MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation Mice |
| title_full | MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation Mice |
| title_fullStr | MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation Mice |
| title_full_unstemmed | MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation Mice |
| title_short | MicroRNA-206 Regulates Stress-Provoked Aggressive Behaviors in Post-weaning Social Isolation Mice |
| title_sort | microrna 206 regulates stress provoked aggressive behaviors in post weaning social isolation mice |
| topic | epigenetics microRNA miR-206 aggression social isolation BDNF |
| url | http://www.sciencedirect.com/science/article/pii/S216225312030127X |
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