Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors

Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors

Summary: The 30+ unique ligands of the TGFβ family signal by forming complexes using different combinations of type I and type II receptors. Therapeutically, the extracellular domain of a single receptor fused to an Fc molecule can effectively neutralize subsets of ligands. Increased ligand specific...

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Bibliographic Details
Main Authors: Erich J. Goebel, Chandramohan Kattamuri, Gregory R. Gipson, Lavanya Krishnan, Moises Chavez, Magdalena Czepnik, Michelle C. Maguire, Rosa Grenha, Maria Håkansson, Derek T. Logan, Asya V. Grinberg, Dianne Sako, Roselyne Castonguay, Ravindra Kumar, Thomas B. Thompson
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:iScience
Subjects:
Biochemistry
Molecular biology
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221015601

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