Factoring in the Complexity of the Cystic Fibrosis Lung to Understand <i>Aspergillus fumigatus</i> and <i>Pseudomonas</i> <i>aeruginosa</i> Interactions
<i>Pseudomonas aeruginosa</i> has long been established as the most prevalent respiratory pathogen in Cystic Fibrosis (CF) patients, with opportunistic infection causing profound morbidity and mortality. Recently, <i>Aspergillus fumigatus</i> has also been recognised as a key...
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MDPI AG
2020-08-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/8/639 |
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| author | Emily Beswick Jorge Amich Sara Gago |
| author_facet | Emily Beswick Jorge Amich Sara Gago |
| author_sort | Emily Beswick |
| collection | DOAJ |
| description | <i>Pseudomonas aeruginosa</i> has long been established as the most prevalent respiratory pathogen in Cystic Fibrosis (CF) patients, with opportunistic infection causing profound morbidity and mortality. Recently, <i>Aspergillus fumigatus</i> has also been recognised as a key contributor to CF lung deterioration, being consistently associated with decreased lung function and worsened prognosis in these patients. As clinical evidence for the common occurrence of combined infection with these two pathogens increases, research into the mechanism and consequences of their interaction is becoming more relevant. Clinical evidence suggests a synergistic effect of combined infection, which translates into a poorer prognosis for the patients. In vitro results from the laboratory have identified a variety of possible synergistic and antagonistic interactions between <i>A. fumigatus</i> and <i>P. aeruginosa</i>. Here, we present a comprehensive overview of the complex environment of the CF lung and discuss how it needs to be considered to determine the exact molecular interactions that <i>A. fumigatus</i> and <i>P. aeruginosa</i> undergo during combined infection and their effects on the host. |
| first_indexed | 2024-03-10T17:51:29Z |
| format | Article |
| id | doaj.art-0b4313efbfe343928f4db54f72731f56 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T17:51:29Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-0b4313efbfe343928f4db54f72731f562023-11-20T09:19:10ZengMDPI AGPathogens2076-08172020-08-019863910.3390/pathogens9080639Factoring in the Complexity of the Cystic Fibrosis Lung to Understand <i>Aspergillus fumigatus</i> and <i>Pseudomonas</i> <i>aeruginosa</i> InteractionsEmily Beswick0Jorge Amich1Sara Gago2Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Core Technology Facility, Grafton Street, Manchester M13 9NT, UKManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Core Technology Facility, Grafton Street, Manchester M13 9NT, UKManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Core Technology Facility, Grafton Street, Manchester M13 9NT, UK<i>Pseudomonas aeruginosa</i> has long been established as the most prevalent respiratory pathogen in Cystic Fibrosis (CF) patients, with opportunistic infection causing profound morbidity and mortality. Recently, <i>Aspergillus fumigatus</i> has also been recognised as a key contributor to CF lung deterioration, being consistently associated with decreased lung function and worsened prognosis in these patients. As clinical evidence for the common occurrence of combined infection with these two pathogens increases, research into the mechanism and consequences of their interaction is becoming more relevant. Clinical evidence suggests a synergistic effect of combined infection, which translates into a poorer prognosis for the patients. In vitro results from the laboratory have identified a variety of possible synergistic and antagonistic interactions between <i>A. fumigatus</i> and <i>P. aeruginosa</i>. Here, we present a comprehensive overview of the complex environment of the CF lung and discuss how it needs to be considered to determine the exact molecular interactions that <i>A. fumigatus</i> and <i>P. aeruginosa</i> undergo during combined infection and their effects on the host.https://www.mdpi.com/2076-0817/9/8/639<i>Aspergillus fumigatus</i><i>Pseudomonas aeruginosa</i>cystic fibrosiscombined infection |
| spellingShingle | Emily Beswick Jorge Amich Sara Gago Factoring in the Complexity of the Cystic Fibrosis Lung to Understand <i>Aspergillus fumigatus</i> and <i>Pseudomonas</i> <i>aeruginosa</i> Interactions Pathogens <i>Aspergillus fumigatus</i> <i>Pseudomonas aeruginosa</i> cystic fibrosis combined infection |
| title | Factoring in the Complexity of the Cystic Fibrosis Lung to Understand <i>Aspergillus fumigatus</i> and <i>Pseudomonas</i> <i>aeruginosa</i> Interactions |
| title_full | Factoring in the Complexity of the Cystic Fibrosis Lung to Understand <i>Aspergillus fumigatus</i> and <i>Pseudomonas</i> <i>aeruginosa</i> Interactions |
| title_fullStr | Factoring in the Complexity of the Cystic Fibrosis Lung to Understand <i>Aspergillus fumigatus</i> and <i>Pseudomonas</i> <i>aeruginosa</i> Interactions |
| title_full_unstemmed | Factoring in the Complexity of the Cystic Fibrosis Lung to Understand <i>Aspergillus fumigatus</i> and <i>Pseudomonas</i> <i>aeruginosa</i> Interactions |
| title_short | Factoring in the Complexity of the Cystic Fibrosis Lung to Understand <i>Aspergillus fumigatus</i> and <i>Pseudomonas</i> <i>aeruginosa</i> Interactions |
| title_sort | factoring in the complexity of the cystic fibrosis lung to understand i aspergillus fumigatus i and i pseudomonas i i aeruginosa i interactions |
| topic | <i>Aspergillus fumigatus</i> <i>Pseudomonas aeruginosa</i> cystic fibrosis combined infection |
| url | https://www.mdpi.com/2076-0817/9/8/639 |
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