Novel Therapeutic Approaches in Neoplastic Meningitis
Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges, or the dura. Neoplastic meningitis (NM), also known by different terms, including leptomeningeal carcinomatosis and carcinomatous meningitis, occurs due to solid tumors and hematologic mali...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/1/119 |
| _version_ | 1797626158736474112 |
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| author | Atulya Aman Khosla Shreya Saxena Ahmad Ozair Vyshak Alva Venur David M. Peereboom Manmeet S. Ahluwalia |
| author_facet | Atulya Aman Khosla Shreya Saxena Ahmad Ozair Vyshak Alva Venur David M. Peereboom Manmeet S. Ahluwalia |
| author_sort | Atulya Aman Khosla |
| collection | DOAJ |
| description | Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges, or the dura. Neoplastic meningitis (NM), also known by different terms, including leptomeningeal carcinomatosis and carcinomatous meningitis, occurs due to solid tumors and hematologic malignancies and is associated with a poor prognosis. The current management paradigm entails a multimodal approach focused on palliation with surgery, radiation, and chemotherapy, which may be administered systemically or directly into the cerebrospinal fluid (CSF). This review focuses on novel therapeutic approaches, including targeted and immunotherapeutic agents under investigation, that have shown promise in NM arising from solid tumors. |
| first_indexed | 2024-03-11T10:06:31Z |
| format | Article |
| id | doaj.art-0b432f051d244617a237502a4aa34dc7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T10:06:31Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0b432f051d244617a237502a4aa34dc72023-11-16T15:01:53ZengMDPI AGCancers2072-66942022-12-0115111910.3390/cancers15010119Novel Therapeutic Approaches in Neoplastic MeningitisAtulya Aman Khosla0Shreya Saxena1Ahmad Ozair2Vyshak Alva Venur3David M. Peereboom4Manmeet S. Ahluwalia5Miami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USAMiami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USAMiami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USAFred Hutchinson Cancer Center, University of Washington, Seattle, WA 98109, USACleveland Clinic Lerner College of Medicine, Cleveland Clinic Main Campus, Cleveland, OH 44195, USAMiami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USACentral nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges, or the dura. Neoplastic meningitis (NM), also known by different terms, including leptomeningeal carcinomatosis and carcinomatous meningitis, occurs due to solid tumors and hematologic malignancies and is associated with a poor prognosis. The current management paradigm entails a multimodal approach focused on palliation with surgery, radiation, and chemotherapy, which may be administered systemically or directly into the cerebrospinal fluid (CSF). This review focuses on novel therapeutic approaches, including targeted and immunotherapeutic agents under investigation, that have shown promise in NM arising from solid tumors.https://www.mdpi.com/2072-6694/15/1/119neoplasticmeningitisleptomeningealchemotherapyradiotherapyintrathecal |
| spellingShingle | Atulya Aman Khosla Shreya Saxena Ahmad Ozair Vyshak Alva Venur David M. Peereboom Manmeet S. Ahluwalia Novel Therapeutic Approaches in Neoplastic Meningitis Cancers neoplastic meningitis leptomeningeal chemotherapy radiotherapy intrathecal |
| title | Novel Therapeutic Approaches in Neoplastic Meningitis |
| title_full | Novel Therapeutic Approaches in Neoplastic Meningitis |
| title_fullStr | Novel Therapeutic Approaches in Neoplastic Meningitis |
| title_full_unstemmed | Novel Therapeutic Approaches in Neoplastic Meningitis |
| title_short | Novel Therapeutic Approaches in Neoplastic Meningitis |
| title_sort | novel therapeutic approaches in neoplastic meningitis |
| topic | neoplastic meningitis leptomeningeal chemotherapy radiotherapy intrathecal |
| url | https://www.mdpi.com/2072-6694/15/1/119 |
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