SERTOLI-LEYDIG CELL TUMOR; A RARE CASE IN A POSTMENOPAUSAL PATIENT – CASE REPORT
Background. Sertoli-Leydig cell tumors belong to the group of sex cord stromal tumors of the ovary. They account for less than 0.5 % of all ovarian tumors and occur primarily in young women between 20 and 30 years of age. This type of tumors can secrete androgens, causing virilisation, and are extre...
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| Format: | Article |
| Language: | English |
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Slovenian Medical Association
2018-02-01
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| Series: | Zdravniški Vestnik |
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| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/2787 |
| _version_ | 1828414240518569984 |
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| author | Petra Krajnc Borut Gorišek Dejan Ognjenovik Damijana Bosilj |
| author_facet | Petra Krajnc Borut Gorišek Dejan Ognjenovik Damijana Bosilj |
| author_sort | Petra Krajnc |
| collection | DOAJ |
| description | Background. Sertoli-Leydig cell tumors belong to the group of sex cord stromal tumors of the ovary. They account for less than 0.5 % of all ovarian tumors and occur primarily in young women between 20 and 30 years of age. This type of tumors can secrete androgens, causing virilisation, and are extremely rarely presented in postmenopausis.
Methods. A 73-year old multiparous woman was presented to our institution with complaints of abdominal distention and abdominal pain in her lower abdomen. On physical examination, she had a large, fixed palpable abdominal mass, approximately 20 cm in diameter, arising from the pelvis. The laboratoric tests revealed an elevated level of CA125 of 221.3 U/ml of serum. The ultrasound showed a complex cystic and solid pelvic tumor. There was no sign of ascites. Her hormonal status was within normal range and she also showed no signs of virilisation. On laparotomy a complex left ovarian mass, measuring 30 × 27 × 15 cm was found and sent to frozen section. The result of frozen section was a malignant tumor of unknown origin, therefore a radical surgical procedure was performed. The histopathological examination established the diagnosis of a malignant Sertoli-Leydig cell tumor of the left ovary, of intermediate differentiation. Other removed tissue was free of malignant cells. The early postoperative course was uneventful and the patient was released from hospital 10 days after surgery. However, she returned to our institution 16 days after surgery due to a proximal thrombosis of v. saphena magna. The patient was treated with low-molecularweight heparin and later warfarin for 6 weeks post operation. 16 months after the operation she was symptomatically treated for severe microcytic anemia. She showed no signs of a relapse. 27 months after primary surgery she was operated for the second time due to acute bowel obstruction. She had large masses of necrotic tumor removed from abdomen and transversostomia was performed. It was found to be a relapse of the malignant Sertoli-Leydig tumor, infiltrating the small intestines; the level of serum CA 125 also showed an increase.
Conclusions. We describe a case of a Sertoli-Leydig cell tumor in a postmenopausal woman, treated in our institution. |
| first_indexed | 2024-12-10T13:24:01Z |
| format | Article |
| id | doaj.art-0b438a53c7644171adb0ad921677d50c |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-12-10T13:24:01Z |
| publishDate | 2018-02-01 |
| publisher | Slovenian Medical Association |
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| series | Zdravniški Vestnik |
| spelling | doaj.art-0b438a53c7644171adb0ad921677d50c2022-12-22T01:47:14ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242018-02-0178010.6016/ZdravVestn.27872140SERTOLI-LEYDIG CELL TUMOR; A RARE CASE IN A POSTMENOPAUSAL PATIENT – CASE REPORTPetra Krajnc0Borut Gorišek1Dejan Ognjenovik2Damijana Bosilj3Oddelek za ginekološko onkologijo in onkologijo dojk Klinika za ginekologijo in perinatologijo UKC Maribor Ljubljanska 5 2000 MariborOddelek za ginekološko onkologijo in onkologijo dojk Klinika za ginekologijo in perinatologijo UKC Maribor Ljubljanska 5 2000 MariborOddelek za ginekologijo in perinatologijo Splošna bolnišnica Ptuj Potrčeva 23 2250 PtujOddelek za ginekološko onkologijo in onkologijo dojk Klinika za ginekologijo in perinatologijo UKC Maribor Ljubljanska 5 2000 MariborBackground. Sertoli-Leydig cell tumors belong to the group of sex cord stromal tumors of the ovary. They account for less than 0.5 % of all ovarian tumors and occur primarily in young women between 20 and 30 years of age. This type of tumors can secrete androgens, causing virilisation, and are extremely rarely presented in postmenopausis. Methods. A 73-year old multiparous woman was presented to our institution with complaints of abdominal distention and abdominal pain in her lower abdomen. On physical examination, she had a large, fixed palpable abdominal mass, approximately 20 cm in diameter, arising from the pelvis. The laboratoric tests revealed an elevated level of CA125 of 221.3 U/ml of serum. The ultrasound showed a complex cystic and solid pelvic tumor. There was no sign of ascites. Her hormonal status was within normal range and she also showed no signs of virilisation. On laparotomy a complex left ovarian mass, measuring 30 × 27 × 15 cm was found and sent to frozen section. The result of frozen section was a malignant tumor of unknown origin, therefore a radical surgical procedure was performed. The histopathological examination established the diagnosis of a malignant Sertoli-Leydig cell tumor of the left ovary, of intermediate differentiation. Other removed tissue was free of malignant cells. The early postoperative course was uneventful and the patient was released from hospital 10 days after surgery. However, she returned to our institution 16 days after surgery due to a proximal thrombosis of v. saphena magna. The patient was treated with low-molecularweight heparin and later warfarin for 6 weeks post operation. 16 months after the operation she was symptomatically treated for severe microcytic anemia. She showed no signs of a relapse. 27 months after primary surgery she was operated for the second time due to acute bowel obstruction. She had large masses of necrotic tumor removed from abdomen and transversostomia was performed. It was found to be a relapse of the malignant Sertoli-Leydig tumor, infiltrating the small intestines; the level of serum CA 125 also showed an increase. Conclusions. We describe a case of a Sertoli-Leydig cell tumor in a postmenopausal woman, treated in our institution.http://vestnik.szd.si/index.php/ZdravVest/article/view/2787jajčnikSertoli-Leydigov tumorpomenopavza |
| spellingShingle | Petra Krajnc Borut Gorišek Dejan Ognjenovik Damijana Bosilj SERTOLI-LEYDIG CELL TUMOR; A RARE CASE IN A POSTMENOPAUSAL PATIENT – CASE REPORT Zdravniški Vestnik jajčnik Sertoli-Leydigov tumor pomenopavza |
| title | SERTOLI-LEYDIG CELL TUMOR; A RARE CASE IN A POSTMENOPAUSAL PATIENT – CASE REPORT |
| title_full | SERTOLI-LEYDIG CELL TUMOR; A RARE CASE IN A POSTMENOPAUSAL PATIENT – CASE REPORT |
| title_fullStr | SERTOLI-LEYDIG CELL TUMOR; A RARE CASE IN A POSTMENOPAUSAL PATIENT – CASE REPORT |
| title_full_unstemmed | SERTOLI-LEYDIG CELL TUMOR; A RARE CASE IN A POSTMENOPAUSAL PATIENT – CASE REPORT |
| title_short | SERTOLI-LEYDIG CELL TUMOR; A RARE CASE IN A POSTMENOPAUSAL PATIENT – CASE REPORT |
| title_sort | sertoli leydig cell tumor a rare case in a postmenopausal patient case report |
| topic | jajčnik Sertoli-Leydigov tumor pomenopavza |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/2787 |
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