Maternal and Fetal Outcomes of Pregnancy in Nephrotic Syndrome Due to Primary Glomerulonephritis
Chronic kidney disease (CKD) affects 3% of pregnancies, impacting on maternal and fetal outcomes, and at the same time, a recurrent question in nephrology regards gestation impact on kidney function. Observational studies stated that CKD stage, pre-existent hypertension, and proteinuria are the main...
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Frontiers Media S.A.
2020-12-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2020.563094/full |
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| author | Rossella Siligato Guido Gembillo Valeria Cernaro Francesco Torre Antonino Salvo Roberta Granese Domenico Santoro |
| author_facet | Rossella Siligato Guido Gembillo Valeria Cernaro Francesco Torre Antonino Salvo Roberta Granese Domenico Santoro |
| author_sort | Rossella Siligato |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) affects 3% of pregnancies, impacting on maternal and fetal outcomes, and at the same time, a recurrent question in nephrology regards gestation impact on kidney function. Observational studies stated that CKD stage, pre-existent hypertension, and proteinuria are the main predictors of possible complications, such as maternal CKD progression, maternal or fetal death, prematurity, small for gestational age (SGA) newborn, or admission to the neonatal intensive care unit. In this regard, given the prominence of proteinuria among other risk factors, we focused on primary nephrotic syndrome in pregnancy, which accounts for 0.028% of cases, and its impact on materno-fetal outcomes and kidney survival. Data extracted from literature are scattered because of the small cohorts investigated in each trial. However, they showed different outcomes for each glomerular disease, with membranous nephropathy (MN) having a better maternal and fetal prognosis than focal and segmental glomerulosclerosis (FSGS), membranoproliferative glomerulonephritis (MPGN), or minimal change disease (MCD). Nephrotic syndrome does not have to discourage women to undertake a pregnancy, but the correct management may include a specific evaluation of risk factors and follow-up for adverse materno-fetal events and/or maternal kidney disease progression. |
| first_indexed | 2024-12-14T16:24:23Z |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-14T16:24:23Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-0b43a1c13e434aee871b56c3f770ee1c2022-12-21T22:54:44ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-12-01710.3389/fmed.2020.563094563094Maternal and Fetal Outcomes of Pregnancy in Nephrotic Syndrome Due to Primary GlomerulonephritisRossella Siligato0Guido Gembillo1Valeria Cernaro2Francesco Torre3Antonino Salvo4Roberta Granese5Domenico Santoro6Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyDepartment of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Messina, ItalyUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyUnit of Gynecology, Department of Human Pathology of Adult and Childhood “G. Barresi”, University of Messina, Messina, ItalyUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyChronic kidney disease (CKD) affects 3% of pregnancies, impacting on maternal and fetal outcomes, and at the same time, a recurrent question in nephrology regards gestation impact on kidney function. Observational studies stated that CKD stage, pre-existent hypertension, and proteinuria are the main predictors of possible complications, such as maternal CKD progression, maternal or fetal death, prematurity, small for gestational age (SGA) newborn, or admission to the neonatal intensive care unit. In this regard, given the prominence of proteinuria among other risk factors, we focused on primary nephrotic syndrome in pregnancy, which accounts for 0.028% of cases, and its impact on materno-fetal outcomes and kidney survival. Data extracted from literature are scattered because of the small cohorts investigated in each trial. However, they showed different outcomes for each glomerular disease, with membranous nephropathy (MN) having a better maternal and fetal prognosis than focal and segmental glomerulosclerosis (FSGS), membranoproliferative glomerulonephritis (MPGN), or minimal change disease (MCD). Nephrotic syndrome does not have to discourage women to undertake a pregnancy, but the correct management may include a specific evaluation of risk factors and follow-up for adverse materno-fetal events and/or maternal kidney disease progression.https://www.frontiersin.org/articles/10.3389/fmed.2020.563094/fullpregnancynephrotic syndromefocal and segmental glomerulosclerosismembranous nephropathymembranoproliferative glomerulonephritisminimal change disease |
| spellingShingle | Rossella Siligato Guido Gembillo Valeria Cernaro Francesco Torre Antonino Salvo Roberta Granese Domenico Santoro Maternal and Fetal Outcomes of Pregnancy in Nephrotic Syndrome Due to Primary Glomerulonephritis Frontiers in Medicine pregnancy nephrotic syndrome focal and segmental glomerulosclerosis membranous nephropathy membranoproliferative glomerulonephritis minimal change disease |
| title | Maternal and Fetal Outcomes of Pregnancy in Nephrotic Syndrome Due to Primary Glomerulonephritis |
| title_full | Maternal and Fetal Outcomes of Pregnancy in Nephrotic Syndrome Due to Primary Glomerulonephritis |
| title_fullStr | Maternal and Fetal Outcomes of Pregnancy in Nephrotic Syndrome Due to Primary Glomerulonephritis |
| title_full_unstemmed | Maternal and Fetal Outcomes of Pregnancy in Nephrotic Syndrome Due to Primary Glomerulonephritis |
| title_short | Maternal and Fetal Outcomes of Pregnancy in Nephrotic Syndrome Due to Primary Glomerulonephritis |
| title_sort | maternal and fetal outcomes of pregnancy in nephrotic syndrome due to primary glomerulonephritis |
| topic | pregnancy nephrotic syndrome focal and segmental glomerulosclerosis membranous nephropathy membranoproliferative glomerulonephritis minimal change disease |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2020.563094/full |
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