GSDMD Mediates LPS-Induced Septic Myocardial Dysfunction by Regulating ROS-dependent NLRP3 Inflammasome Activation

GSDMD Mediates LPS-Induced Septic Myocardial Dysfunction by Regulating ROS-dependent NLRP3 Inflammasome Activation

Myocardial dysfunction is a serious consequence of sepsis and contributes to high mortality. Currently, the molecular mechanism of myocardial dysfunction induced by sepsis remains unclear. In the present study, we investigated the role of gasdermin D (GSDMD) in cardiac dysfunction in septic mice and...

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Bibliographic Details
Main Authors: Shanshan Dai, Bozhi Ye, Lingfeng Zhong, Yanghao Chen, Guangliang Hong, Guangju Zhao, Lan Su, Zhongqiu Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
gasdermin D
sepsis
myocardial dysfunction
reactive oxygen species
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.779432/full

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