Effectiveness of 17-Alpha-Hydroxyprogesterone in the Prevention of Preterm Labour
Objective: To compare the effectiveness of 17-Alpha- Hydroxyprogesterone in preventing preterm labour. Study Design: Prospective longitudinal study. Place and Duration of Study: Department of Obstetrics and Gynecology, Combined Military Hospital, Sakardu Pakistan, from Jun to Dec 2019. Met...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2023-03-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/5314 |
| _version_ | 1797856256781713408 |
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| author | Uzma Urooj Sumaira Khan Shakeela Parveen Sajid Ali Shah |
| author_facet | Uzma Urooj Sumaira Khan Shakeela Parveen Sajid Ali Shah |
| author_sort | Uzma Urooj |
| collection | DOAJ |
| description |
Objective: To compare the effectiveness of 17-Alpha- Hydroxyprogesterone in preventing preterm labour.
Study Design: Prospective longitudinal study.
Place and Duration of Study: Department of Obstetrics and Gynecology, Combined Military Hospital, Sakardu Pakistan, from Jun to Dec 2019.
Methodology: A total of 208 patients (104 in each group) were recruited in this study. Group-A 17-alpha-hydroxyprogesterone (250mg) intramuscular injection was given weekly from 20-36 weeks of gestation or delivery, whichever occurred first. GroupB (Control Group) received no treatment except routine antenatal care but was treated actively with tocolytic drugs and corticosteroids if they presented with preterm labour.
Results: Mean age of the patients was 26.1±4.9 and 25.7±4.5 in Group-A and B, respectively. In Group-A (17-alphahydroxyprogesterone), the mean gestational age at delivery was 36.8±3.8; in Group-B (control), the mean gestational age was 35.7±1.3. Treatment was efficacious in 82 patients (78.8%) in Group-A and 65(62.5%) in Group-B. The difference was statistically significant between the two groups (p=0.009).
Conclusion: 17 Alpha-Hydroxyprogesterone caproate preventive therapy likely plays an important role in reducing the risk of recurrent preterm birth.
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| first_indexed | 2024-04-09T20:37:26Z |
| format | Article |
| id | doaj.art-0b487274e8454ea7bf8b68f3fafc7505 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-04-09T20:37:26Z |
| publishDate | 2023-03-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-0b487274e8454ea7bf8b68f3fafc75052023-03-30T06:25:00ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422023-03-0173110.51253/pafmj.v73i1.5314Effectiveness of 17-Alpha-Hydroxyprogesterone in the Prevention of Preterm LabourUzma Urooj0Sumaira Khan1Shakeela Parveen2Sajid Ali Shah3Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi, PakistanPak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi, PakistanCombined Military Hospital, Skardu/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital, Skardu/National University of Medical Sciences (NUMS) Pakistan Objective: To compare the effectiveness of 17-Alpha- Hydroxyprogesterone in preventing preterm labour. Study Design: Prospective longitudinal study. Place and Duration of Study: Department of Obstetrics and Gynecology, Combined Military Hospital, Sakardu Pakistan, from Jun to Dec 2019. Methodology: A total of 208 patients (104 in each group) were recruited in this study. Group-A 17-alpha-hydroxyprogesterone (250mg) intramuscular injection was given weekly from 20-36 weeks of gestation or delivery, whichever occurred first. GroupB (Control Group) received no treatment except routine antenatal care but was treated actively with tocolytic drugs and corticosteroids if they presented with preterm labour. Results: Mean age of the patients was 26.1±4.9 and 25.7±4.5 in Group-A and B, respectively. In Group-A (17-alphahydroxyprogesterone), the mean gestational age at delivery was 36.8±3.8; in Group-B (control), the mean gestational age was 35.7±1.3. Treatment was efficacious in 82 patients (78.8%) in Group-A and 65(62.5%) in Group-B. The difference was statistically significant between the two groups (p=0.009). Conclusion: 17 Alpha-Hydroxyprogesterone caproate preventive therapy likely plays an important role in reducing the risk of recurrent preterm birth. https://www.pafmj.org/index.php/PAFMJ/article/view/5314Antenatal carePreventionRecurrent preterm delivery17-Alpha-hydroxyprogesteroneTocolytic drugs |
| spellingShingle | Uzma Urooj Sumaira Khan Shakeela Parveen Sajid Ali Shah Effectiveness of 17-Alpha-Hydroxyprogesterone in the Prevention of Preterm Labour Pakistan Armed Forces Medical Journal Antenatal care Prevention Recurrent preterm delivery 17-Alpha-hydroxyprogesterone Tocolytic drugs |
| title | Effectiveness of 17-Alpha-Hydroxyprogesterone in the Prevention of Preterm Labour |
| title_full | Effectiveness of 17-Alpha-Hydroxyprogesterone in the Prevention of Preterm Labour |
| title_fullStr | Effectiveness of 17-Alpha-Hydroxyprogesterone in the Prevention of Preterm Labour |
| title_full_unstemmed | Effectiveness of 17-Alpha-Hydroxyprogesterone in the Prevention of Preterm Labour |
| title_short | Effectiveness of 17-Alpha-Hydroxyprogesterone in the Prevention of Preterm Labour |
| title_sort | effectiveness of 17 alpha hydroxyprogesterone in the prevention of preterm labour |
| topic | Antenatal care Prevention Recurrent preterm delivery 17-Alpha-hydroxyprogesterone Tocolytic drugs |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/5314 |
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