HMGB1, S100 proteins and other RAGE ligands in cancer - markers, mediators and putative therapeutic targets
Background and Aims: Activation of RAGE due to its increased expression in cancer cells or its stimulation by multiple ligands (AGEs, HMGB1, S100 proteins, etc.) may contribute to the proliferation, invasiveness of tumor cells and formation of distant metastases and also to the resistance of cancer...
| Main Authors: | , , , |
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| Format: | Article |
| Jezik: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2016-03-01
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| Serija: | Biomedical Papers |
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| Online dostop: | https://biomed.papers.upol.cz/artkey/bio-201601-0001_HMGB1_S100_proteins_and_other_RAGE_ligands_in_cancer_-_markers_mediators_and_putative_therapeutic_targets.php |
| _version_ | 1828392288904019968 |
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| author | Petra Tesarova Marta Kalousova Tomas Zima Vladimir Tesar |
| author_facet | Petra Tesarova Marta Kalousova Tomas Zima Vladimir Tesar |
| author_sort | Petra Tesarova |
| collection | DOAJ |
| description | Background and Aims: Activation of RAGE due to its increased expression in cancer cells or its stimulation by multiple ligands (AGEs, HMGB1, S100 proteins, etc.) may contribute to the proliferation, invasiveness of tumor cells and formation of distant metastases and also to the resistance of cancer to treatment. RAGE ligands could thus become both useful markers of disease severity and its outcome and, a potential therapeutic target.
Conclusions: Better understanding of the role of RAGE activation in different types of cancer may help to define the role of ligand/RAGE antagonists as promising cancer treatment. |
| first_indexed | 2024-12-10T07:17:34Z |
| format | Article |
| id | doaj.art-0b4aad38470748ec8782c06e33a25a23 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-10T07:17:34Z |
| publishDate | 2016-03-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-0b4aad38470748ec8782c06e33a25a232022-12-22T01:57:53ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212016-03-01160111010.5507/bp.2016.003bio-201601-0001HMGB1, S100 proteins and other RAGE ligands in cancer - markers, mediators and putative therapeutic targetsPetra Tesarova0Marta Kalousova1Tomas Zima2Vladimir Tesar3Department of Oncology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech RepublicInstitute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech RepublicInstitute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech RepublicDepartment of Nephrology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech RepublicBackground and Aims: Activation of RAGE due to its increased expression in cancer cells or its stimulation by multiple ligands (AGEs, HMGB1, S100 proteins, etc.) may contribute to the proliferation, invasiveness of tumor cells and formation of distant metastases and also to the resistance of cancer to treatment. RAGE ligands could thus become both useful markers of disease severity and its outcome and, a potential therapeutic target. Conclusions: Better understanding of the role of RAGE activation in different types of cancer may help to define the role of ligand/RAGE antagonists as promising cancer treatment.https://biomed.papers.upol.cz/artkey/bio-201601-0001_HMGB1_S100_proteins_and_other_RAGE_ligands_in_cancer_-_markers_mediators_and_putative_therapeutic_targets.phpragehmgb1s100 proteinsadvanced glycation end productscancermetastasis |
| spellingShingle | Petra Tesarova Marta Kalousova Tomas Zima Vladimir Tesar HMGB1, S100 proteins and other RAGE ligands in cancer - markers, mediators and putative therapeutic targets Biomedical Papers rage hmgb1 s100 proteins advanced glycation end products cancer metastasis |
| title | HMGB1, S100 proteins and other RAGE ligands in cancer - markers, mediators and putative therapeutic targets |
| title_full | HMGB1, S100 proteins and other RAGE ligands in cancer - markers, mediators and putative therapeutic targets |
| title_fullStr | HMGB1, S100 proteins and other RAGE ligands in cancer - markers, mediators and putative therapeutic targets |
| title_full_unstemmed | HMGB1, S100 proteins and other RAGE ligands in cancer - markers, mediators and putative therapeutic targets |
| title_short | HMGB1, S100 proteins and other RAGE ligands in cancer - markers, mediators and putative therapeutic targets |
| title_sort | hmgb1 s100 proteins and other rage ligands in cancer markers mediators and putative therapeutic targets |
| topic | rage hmgb1 s100 proteins advanced glycation end products cancer metastasis |
| url | https://biomed.papers.upol.cz/artkey/bio-201601-0001_HMGB1_S100_proteins_and_other_RAGE_ligands_in_cancer_-_markers_mediators_and_putative_therapeutic_targets.php |
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