Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus
Epigenetic reprogramming represents a series of essential events during many cellular processes including oncogenesis. The genome of Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic herpesvirus, is predetermined for a well-orchestrated epigenetic reprogramming once it enters into the hos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14955 |
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| author | Anusha Srivastava Ankit Srivastava Rajnish Kumar Singh |
| author_facet | Anusha Srivastava Ankit Srivastava Rajnish Kumar Singh |
| author_sort | Anusha Srivastava |
| collection | DOAJ |
| description | Epigenetic reprogramming represents a series of essential events during many cellular processes including oncogenesis. The genome of Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic herpesvirus, is predetermined for a well-orchestrated epigenetic reprogramming once it enters into the host cell. The initial epigenetic reprogramming of the KSHV genome allows restricted expression of encoded genes and helps to hide from host immune recognition. Infection with KSHV is associated with Kaposi’s sarcoma, multicentric Castleman’s disease, KSHV inflammatory cytokine syndrome, and primary effusion lymphoma. The major epigenetic modifications associated with KSHV can be labeled under three broad categories: DNA methylation, histone modifications, and the role of noncoding RNAs. These epigenetic modifications significantly contribute toward the latent–lytic switch of the KSHV lifecycle. This review gives a brief account of the major epigenetic modifications affiliated with the KSHV genome in infected cells and their impact on pathogenesis. |
| first_indexed | 2024-03-10T21:42:23Z |
| format | Article |
| id | doaj.art-0b4ac0187abf4cd2a56440c92b51a551 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:42:23Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0b4ac0187abf4cd2a56440c92b51a5512023-11-19T14:33:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124191495510.3390/ijms241914955Insight into the Epigenetics of Kaposi’s Sarcoma-Associated HerpesvirusAnusha Srivastava0Ankit Srivastava1Rajnish Kumar Singh2Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, IndiaInstitute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, IndiaInstitute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, IndiaEpigenetic reprogramming represents a series of essential events during many cellular processes including oncogenesis. The genome of Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic herpesvirus, is predetermined for a well-orchestrated epigenetic reprogramming once it enters into the host cell. The initial epigenetic reprogramming of the KSHV genome allows restricted expression of encoded genes and helps to hide from host immune recognition. Infection with KSHV is associated with Kaposi’s sarcoma, multicentric Castleman’s disease, KSHV inflammatory cytokine syndrome, and primary effusion lymphoma. The major epigenetic modifications associated with KSHV can be labeled under three broad categories: DNA methylation, histone modifications, and the role of noncoding RNAs. These epigenetic modifications significantly contribute toward the latent–lytic switch of the KSHV lifecycle. This review gives a brief account of the major epigenetic modifications affiliated with the KSHV genome in infected cells and their impact on pathogenesis.https://www.mdpi.com/1422-0067/24/19/14955Kaposi’s sarcoma-associated herpes virusepigeneticsDNA methylationhistone modificationnoncoding RNAsoncogenesis |
| spellingShingle | Anusha Srivastava Ankit Srivastava Rajnish Kumar Singh Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus International Journal of Molecular Sciences Kaposi’s sarcoma-associated herpes virus epigenetics DNA methylation histone modification noncoding RNAs oncogenesis |
| title | Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus |
| title_full | Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus |
| title_fullStr | Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus |
| title_full_unstemmed | Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus |
| title_short | Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus |
| title_sort | insight into the epigenetics of kaposi s sarcoma associated herpesvirus |
| topic | Kaposi’s sarcoma-associated herpes virus epigenetics DNA methylation histone modification noncoding RNAs oncogenesis |
| url | https://www.mdpi.com/1422-0067/24/19/14955 |
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