Transformation of Malignant Melanoma From Giant Nevus in Infantile Penis
Background: Malignant melanoma is the most serious type of skin cancer, and its incidence rate increases with age. Malignant melanoma in infants has been rarely reported in the literature. Herein, we report a case of malignant transformation of a nodular lesion found in the penis of a patient with a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2020.594803/full |
| _version_ | 1819061069658718208 |
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| author | Dong Hwan Lee Min Ji Kim Il Jae Lee Dong Ha Park |
| author_facet | Dong Hwan Lee Min Ji Kim Il Jae Lee Dong Ha Park |
| author_sort | Dong Hwan Lee |
| collection | DOAJ |
| description | Background: Malignant melanoma is the most serious type of skin cancer, and its incidence rate increases with age. Malignant melanoma in infants has been rarely reported in the literature. Herein, we report a case of malignant transformation of a nodular lesion found in the penis of a patient with a giant congenital nevus.Case presentation: A 1-month-old male patient was admitted due to the presence of a giant congenital nevus involving the lower abdomen, bilateral inguinal areas, genitals, and left thigh and knee. Six months later, nodules measuring 1 cm in diameter protruding from the genital area were noted, and a part of the nodule was removed via elliptical excision with the patient under general anesthesia. Gross examination showed an edematous lesion similar to a neurofibroma and with unclear boundaries. Biopsy revealed a malignant melanoma, with a Breslow thickness of at least 3 mm, and absence of lymphovascular invasion; the biopsy confirmed incomplete excision. The patient was scheduled for radical resection, but reconstruction was not performed following surgical resection due to the guardian's refusal. Hence, the patient only received an adjuvant medical treatment and eventually died.Conclusion: We reported a rare case of an infant with a malignant melanoma in the penis. Congenital malignant melanoma rarely occurs in infants; however, due to its fatal consequences, follow-up should be performed to assess for malignant changes. |
| first_indexed | 2024-12-21T14:37:02Z |
| format | Article |
| id | doaj.art-0b4b64543ca84741b04821d00e41b868 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-12-21T14:37:02Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-0b4b64543ca84741b04821d00e41b8682022-12-21T19:00:17ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2020-12-01710.3389/fsurg.2020.594803594803Transformation of Malignant Melanoma From Giant Nevus in Infantile PenisDong Hwan LeeMin Ji KimIl Jae LeeDong Ha ParkBackground: Malignant melanoma is the most serious type of skin cancer, and its incidence rate increases with age. Malignant melanoma in infants has been rarely reported in the literature. Herein, we report a case of malignant transformation of a nodular lesion found in the penis of a patient with a giant congenital nevus.Case presentation: A 1-month-old male patient was admitted due to the presence of a giant congenital nevus involving the lower abdomen, bilateral inguinal areas, genitals, and left thigh and knee. Six months later, nodules measuring 1 cm in diameter protruding from the genital area were noted, and a part of the nodule was removed via elliptical excision with the patient under general anesthesia. Gross examination showed an edematous lesion similar to a neurofibroma and with unclear boundaries. Biopsy revealed a malignant melanoma, with a Breslow thickness of at least 3 mm, and absence of lymphovascular invasion; the biopsy confirmed incomplete excision. The patient was scheduled for radical resection, but reconstruction was not performed following surgical resection due to the guardian's refusal. Hence, the patient only received an adjuvant medical treatment and eventually died.Conclusion: We reported a rare case of an infant with a malignant melanoma in the penis. Congenital malignant melanoma rarely occurs in infants; however, due to its fatal consequences, follow-up should be performed to assess for malignant changes.https://www.frontiersin.org/articles/10.3389/fsurg.2020.594803/fullmelanomapediatric tumorpenile neoplasms pathologytransformationpediatric surgery |
| spellingShingle | Dong Hwan Lee Min Ji Kim Il Jae Lee Dong Ha Park Transformation of Malignant Melanoma From Giant Nevus in Infantile Penis Frontiers in Surgery melanoma pediatric tumor penile neoplasms pathology transformation pediatric surgery |
| title | Transformation of Malignant Melanoma From Giant Nevus in Infantile Penis |
| title_full | Transformation of Malignant Melanoma From Giant Nevus in Infantile Penis |
| title_fullStr | Transformation of Malignant Melanoma From Giant Nevus in Infantile Penis |
| title_full_unstemmed | Transformation of Malignant Melanoma From Giant Nevus in Infantile Penis |
| title_short | Transformation of Malignant Melanoma From Giant Nevus in Infantile Penis |
| title_sort | transformation of malignant melanoma from giant nevus in infantile penis |
| topic | melanoma pediatric tumor penile neoplasms pathology transformation pediatric surgery |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2020.594803/full |
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