Evaluation the sedative and analgesic effects of tramadol and chlorpromazine alone or as a combination in chicks
The goal of this study was to assess the pain-relieving action of tramadol alone or when administered with chlorpromazine and screening for analgesic effects by using sedative non-analgesic doses of tramadol and chlorpromazine when injected together in chicks. the analgesic ED50 of tramadol was 0....
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Veterinary Medicine, University of Kufa
2021-06-01
|
| Series: | Kufa Journal for Veterinary Medical Sciences |
| Subjects: | |
| Online Access: | https://journal.uokufa.edu.iq/index.php/kjvs/article/view/3221 |
| Summary: | The goal of this study was to assess the pain-relieving action of tramadol alone or when administered with chlorpromazine and screening for analgesic effects by using sedative non-analgesic doses of tramadol and chlorpromazine when injected together in chicks. the analgesic ED50 of tramadol was 0.8 mg/kg body weight ( intra muscular injection), and the sedative ED50 of chlorpromazine was 8.6 mg / kg of body weight (intraperitoneal injection). Based on Isopolographic analysis, the type of drug interaction between tramadol and chlorpromazine was determined when injected together in a ratio by 1: 1, 1: 0.5 and 0.5: 0.5 from the median effective dose(ED50 )of tramadol and the median effective dose of chlorpromazine was synergetic interaction. Thus conclude that combination of tramadol and chlorpromazine with sedative non-analgesic doses is ideal for a good analgesic effect of pain in chicks |
|---|---|
| ISSN: | 2077-9798 2959-8478 |