Evolution of vertebrate interferon inducible transmembrane proteins
<p>Abstract</p> <p>Background</p> <p>Interferon inducible transmembrane proteins (IFITMs) have diverse roles, including the control of cell proliferation, promotion of homotypic cell adhesion, protection against viral infection, promotion of bone matrix maturation and m...
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| Format: | Article |
| Language: | English |
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BMC
2012-04-01
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| Series: | BMC Genomics |
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| Online Access: | http://www.biomedcentral.com/1471-2164/13/155 |
| _version_ | 1818755529703424000 |
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| author | Hickford Danielle Frankenberg Stephen Shaw Geoff Renfree Marilyn B |
| author_facet | Hickford Danielle Frankenberg Stephen Shaw Geoff Renfree Marilyn B |
| author_sort | Hickford Danielle |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Interferon inducible transmembrane proteins (IFITMs) have diverse roles, including the control of cell proliferation, promotion of homotypic cell adhesion, protection against viral infection, promotion of bone matrix maturation and mineralisation, and mediating germ cell development. Most IFITMs have been well characterised in human and mouse but little published data exists for other animals. This study characterised IFITMs in two distantly related marsupial species, the Australian tammar wallaby and the South American grey short-tailed opossum, and analysed the phylogeny of the IFITM family in vertebrates.</p> <p>Results</p> <p>Five IFITM paralogues were identified in both the tammar and opossum. As in eutherians, most marsupial <it>IFITM</it> genes exist within a cluster, contain two exons and encode proteins with two transmembrane domains. Only two <it>IFITM</it> genes, <it>IFITM5</it> and <it>IFITM10</it>, have orthologues in both marsupials and eutherians. <it>IFITM5</it> arose in bony fish and <it>IFITM10</it> in tetrapods. The bone-specific expression of <it>IFITM5</it> appears to be restricted to therian mammals, suggesting that its specialised role in bone production is a recent adaptation specific to mammals. IFITM10 is the most highly conserved IFITM, sharing at least 85% amino acid identity between birds, reptiles and mammals and suggesting an important role for this presently uncharacterised protein.</p> <p>Conclusions</p> <p>Like eutherians, marsupials also have multiple IFITM genes that exist in a gene cluster. The differing expression patterns for many of the paralogues, together with poor sequence conservation between species, suggests that <it>IFITM</it> genes have acquired many different roles during vertebrate evolution.</p> |
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| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-18T05:40:36Z |
| publishDate | 2012-04-01 |
| publisher | BMC |
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| series | BMC Genomics |
| spelling | doaj.art-0b4f574cffcc4b1a90c56a89b079e8d82022-12-21T21:19:10ZengBMCBMC Genomics1471-21642012-04-0113115510.1186/1471-2164-13-155Evolution of vertebrate interferon inducible transmembrane proteinsHickford DanielleFrankenberg StephenShaw GeoffRenfree Marilyn B<p>Abstract</p> <p>Background</p> <p>Interferon inducible transmembrane proteins (IFITMs) have diverse roles, including the control of cell proliferation, promotion of homotypic cell adhesion, protection against viral infection, promotion of bone matrix maturation and mineralisation, and mediating germ cell development. Most IFITMs have been well characterised in human and mouse but little published data exists for other animals. This study characterised IFITMs in two distantly related marsupial species, the Australian tammar wallaby and the South American grey short-tailed opossum, and analysed the phylogeny of the IFITM family in vertebrates.</p> <p>Results</p> <p>Five IFITM paralogues were identified in both the tammar and opossum. As in eutherians, most marsupial <it>IFITM</it> genes exist within a cluster, contain two exons and encode proteins with two transmembrane domains. Only two <it>IFITM</it> genes, <it>IFITM5</it> and <it>IFITM10</it>, have orthologues in both marsupials and eutherians. <it>IFITM5</it> arose in bony fish and <it>IFITM10</it> in tetrapods. The bone-specific expression of <it>IFITM5</it> appears to be restricted to therian mammals, suggesting that its specialised role in bone production is a recent adaptation specific to mammals. IFITM10 is the most highly conserved IFITM, sharing at least 85% amino acid identity between birds, reptiles and mammals and suggesting an important role for this presently uncharacterised protein.</p> <p>Conclusions</p> <p>Like eutherians, marsupials also have multiple IFITM genes that exist in a gene cluster. The differing expression patterns for many of the paralogues, together with poor sequence conservation between species, suggests that <it>IFITM</it> genes have acquired many different roles during vertebrate evolution.</p>http://www.biomedcentral.com/1471-2164/13/155MarsupialTammar wallabyOpossumGene cluster |
| spellingShingle | Hickford Danielle Frankenberg Stephen Shaw Geoff Renfree Marilyn B Evolution of vertebrate interferon inducible transmembrane proteins BMC Genomics Marsupial Tammar wallaby Opossum Gene cluster |
| title | Evolution of vertebrate interferon inducible transmembrane proteins |
| title_full | Evolution of vertebrate interferon inducible transmembrane proteins |
| title_fullStr | Evolution of vertebrate interferon inducible transmembrane proteins |
| title_full_unstemmed | Evolution of vertebrate interferon inducible transmembrane proteins |
| title_short | Evolution of vertebrate interferon inducible transmembrane proteins |
| title_sort | evolution of vertebrate interferon inducible transmembrane proteins |
| topic | Marsupial Tammar wallaby Opossum Gene cluster |
| url | http://www.biomedcentral.com/1471-2164/13/155 |
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