Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia
Introduction Thrombocytopenia is a common complication in malaria patients. The relationship between abnormal platelet profile and clinical status in malaria patients is unclear. In low and unstable endemic regions where vivax malaria predominates, the hematologic profiles of malaria patients and th...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
2014-06-01
|
| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000300341&lng=en&tlng=en |
| _version_ | 1811232827658731520 |
|---|---|
| author | Edgar Leonardo Martínez-Salazar Alberto Tobón-Castaño |
| author_facet | Edgar Leonardo Martínez-Salazar Alberto Tobón-Castaño |
| author_sort | Edgar Leonardo Martínez-Salazar |
| collection | DOAJ |
| description | Introduction Thrombocytopenia is a common complication in malaria patients. The relationship between abnormal platelet profile and clinical status in malaria patients is unclear. In low and unstable endemic regions where vivax malaria predominates, the hematologic profiles of malaria patients and their clinical utility are poorly understood. The aim of this study was to characterize the thrombograms of malaria patients from Colombia, where Plasmodium vivax infection is common, and to explore the relationship between thrombograms and clinical status. Methods Eight hundred sixty-two malaria patients were enrolled, including 533 (61.8%) patients infected with Plasmodium falciparum, 311 (36.1%) patients infected with Plasmodium vivax and 18 (2.1%) patients with mixed infections. Results The most frequently observed changes were low platelet count (PC) and high platelet distribution width (PDW), which were observed in 65% of patients; thrombocytopenia with <50,000 platelets/µL was identified in 11% of patients. Patients with complications had lower PC and plateletcrit (PT) and higher PDW values. A higher risk of thrombocytopenia was identified in patients with severe anemia, neurologic complications, pulmonary complications, liver dysfunction, renal impairment and severe hypoglycemia. The presence of thrombocytopenia (<150,000 platelets/µL) was associated with a higher probability of liver dysfunction. Conclusions Young age, longer duration of illness and higher parasitemia are associated with severe thrombocytopenia. Our study showed that thrombocytopenia is related to malaria complications, especially liver dysfunction. High PDW in patients with severe malaria may explain the mechanisms of thrombocytopenia that is common in this group of patients. |
| first_indexed | 2024-04-12T11:10:49Z |
| format | Article |
| id | doaj.art-0b4f5c9160b74ee5ab3a4f205cc5ed50 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-12T11:10:49Z |
| publishDate | 2014-06-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-0b4f5c9160b74ee5ab3a4f205cc5ed502022-12-22T03:35:37ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492014-06-0147334134910.1590/0037-8682-0078-2014S0037-86822014000300341Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in ColombiaEdgar Leonardo Martínez-SalazarAlberto Tobón-CastañoIntroduction Thrombocytopenia is a common complication in malaria patients. The relationship between abnormal platelet profile and clinical status in malaria patients is unclear. In low and unstable endemic regions where vivax malaria predominates, the hematologic profiles of malaria patients and their clinical utility are poorly understood. The aim of this study was to characterize the thrombograms of malaria patients from Colombia, where Plasmodium vivax infection is common, and to explore the relationship between thrombograms and clinical status. Methods Eight hundred sixty-two malaria patients were enrolled, including 533 (61.8%) patients infected with Plasmodium falciparum, 311 (36.1%) patients infected with Plasmodium vivax and 18 (2.1%) patients with mixed infections. Results The most frequently observed changes were low platelet count (PC) and high platelet distribution width (PDW), which were observed in 65% of patients; thrombocytopenia with <50,000 platelets/µL was identified in 11% of patients. Patients with complications had lower PC and plateletcrit (PT) and higher PDW values. A higher risk of thrombocytopenia was identified in patients with severe anemia, neurologic complications, pulmonary complications, liver dysfunction, renal impairment and severe hypoglycemia. The presence of thrombocytopenia (<150,000 platelets/µL) was associated with a higher probability of liver dysfunction. Conclusions Young age, longer duration of illness and higher parasitemia are associated with severe thrombocytopenia. Our study showed that thrombocytopenia is related to malaria complications, especially liver dysfunction. High PDW in patients with severe malaria may explain the mechanisms of thrombocytopenia that is common in this group of patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000300341&lng=en&tlng=enThrombogramThrombocytopeniaPlateletPlasmodiumSevere malariaColombia |
| spellingShingle | Edgar Leonardo Martínez-Salazar Alberto Tobón-Castaño Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia Revista da Sociedade Brasileira de Medicina Tropical Thrombogram Thrombocytopenia Platelet Plasmodium Severe malaria Colombia |
| title | Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia |
| title_full | Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia |
| title_fullStr | Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia |
| title_full_unstemmed | Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia |
| title_short | Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia |
| title_sort | platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in colombia |
| topic | Thrombogram Thrombocytopenia Platelet Plasmodium Severe malaria Colombia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000300341&lng=en&tlng=en |
| work_keys_str_mv | AT edgarleonardomartinezsalazar plateletprofileisassociatedwithclinicalcomplicationsinpatientswithvivaxandfalciparummalariaincolombia AT albertotoboncastano plateletprofileisassociatedwithclinicalcomplicationsinpatientswithvivaxandfalciparummalariaincolombia |