Tamoxifen from chemotherapy to antiviral drug: Possible activity against COVID-19
Tamoxifen (TAM) is the oldest and the most-prescribed selective estrogen receptor modulator (SERM). It is a member of the triphenylethylene group. TAM has been used to treat breast cancer that spreads to other parts of the human body; it is also utilized to decreasing the chances of breast cancer de...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Biomedical and Biotechnology Research Journal |
| Subjects: | |
| Online Access: | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2020;volume=4;issue=2;spage=108;epage=116;aulast=Almosawey |
| _version_ | 1818500669899800576 |
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| author | Huda Ali Salman Almosawey Falah Hasan Obayes AL-Khikani Raghdah Maytham Hameed Younus Jasim Abdullah Mohanad Kadhim Mirdan Al-Ibraheemi Atyaf Ali Al-Asadi |
| author_facet | Huda Ali Salman Almosawey Falah Hasan Obayes AL-Khikani Raghdah Maytham Hameed Younus Jasim Abdullah Mohanad Kadhim Mirdan Al-Ibraheemi Atyaf Ali Al-Asadi |
| author_sort | Huda Ali Salman Almosawey |
| collection | DOAJ |
| description | Tamoxifen (TAM) is the oldest and the most-prescribed selective estrogen receptor modulator (SERM). It is a member of the triphenylethylene group. TAM has been used to treat breast cancer that spreads to other parts of the human body; it is also utilized to decreasing the chances of breast cancer developing in high-risk patients. Recently, some studies focused on the potential antimicrobial action of TAM. Coronaviruses are enveloped positive-sense RNA nucleic acid viruses that have club-like spikes, characterized by a distinctive replication strategy; they are round and sometimes pleomorphic in shape. Coronavirus disease 2019 (COVID-19) is regarding the new genera of coronaviredia that appeared for the first time in Wuhan, China, in early December 2019. Due to the continuous spread of the novel COVID-19 with the exponential rise in death numbers, new therapeutic development is urgent; in general, there are no specific antiviral drugs or vaccines for 2019-nCoV. Hence, this review will discuss the most recent information about the antiviral action of TAM against COVID-19 infection by trying to give a deep understanding of major properties, mechanisms of action, immune system responses, and antimicrobial efficiency of TAM that is regarding the promising way to treat COVID-19 novel infection. The current review may serve as an impetus for researchers working in the field of medical microbiology, vaccination, and antiviral drug design. The review also rationally reports and critically analyzes the available knowledge by focusing and mentioning future steps and strategies trying to find appropriate solutions regarding challenges in COVID-19 management by TAM utilization. |
| first_indexed | 2024-12-10T20:45:52Z |
| format | Article |
| id | doaj.art-0b51c6682404428486d85338740297e4 |
| institution | Directory Open Access Journal |
| issn | 2588-9834 2588-9842 |
| language | English |
| last_indexed | 2024-12-10T20:45:52Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Biomedical and Biotechnology Research Journal |
| spelling | doaj.art-0b51c6682404428486d85338740297e42022-12-22T01:34:14ZengWolters Kluwer Medknow PublicationsBiomedical and Biotechnology Research Journal2588-98342588-98422020-01-014210811610.4103/bbrj.bbrj_53_20Tamoxifen from chemotherapy to antiviral drug: Possible activity against COVID-19Huda Ali Salman AlmosaweyFalah Hasan Obayes AL-KhikaniRaghdah Maytham HameedYounus Jasim AbdullahMohanad Kadhim Mirdan Al-IbraheemiAtyaf Ali Al-AsadiTamoxifen (TAM) is the oldest and the most-prescribed selective estrogen receptor modulator (SERM). It is a member of the triphenylethylene group. TAM has been used to treat breast cancer that spreads to other parts of the human body; it is also utilized to decreasing the chances of breast cancer developing in high-risk patients. Recently, some studies focused on the potential antimicrobial action of TAM. Coronaviruses are enveloped positive-sense RNA nucleic acid viruses that have club-like spikes, characterized by a distinctive replication strategy; they are round and sometimes pleomorphic in shape. Coronavirus disease 2019 (COVID-19) is regarding the new genera of coronaviredia that appeared for the first time in Wuhan, China, in early December 2019. Due to the continuous spread of the novel COVID-19 with the exponential rise in death numbers, new therapeutic development is urgent; in general, there are no specific antiviral drugs or vaccines for 2019-nCoV. Hence, this review will discuss the most recent information about the antiviral action of TAM against COVID-19 infection by trying to give a deep understanding of major properties, mechanisms of action, immune system responses, and antimicrobial efficiency of TAM that is regarding the promising way to treat COVID-19 novel infection. The current review may serve as an impetus for researchers working in the field of medical microbiology, vaccination, and antiviral drug design. The review also rationally reports and critically analyzes the available knowledge by focusing and mentioning future steps and strategies trying to find appropriate solutions regarding challenges in COVID-19 management by TAM utilization.http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2020;volume=4;issue=2;spage=108;epage=116;aulast=Almosaweyantimicrobial agentsantiviral drugschemotherapycoronaviruscovid-19tamoxifen |
| spellingShingle | Huda Ali Salman Almosawey Falah Hasan Obayes AL-Khikani Raghdah Maytham Hameed Younus Jasim Abdullah Mohanad Kadhim Mirdan Al-Ibraheemi Atyaf Ali Al-Asadi Tamoxifen from chemotherapy to antiviral drug: Possible activity against COVID-19 Biomedical and Biotechnology Research Journal antimicrobial agents antiviral drugs chemotherapy coronavirus covid-19 tamoxifen |
| title | Tamoxifen from chemotherapy to antiviral drug: Possible activity against COVID-19 |
| title_full | Tamoxifen from chemotherapy to antiviral drug: Possible activity against COVID-19 |
| title_fullStr | Tamoxifen from chemotherapy to antiviral drug: Possible activity against COVID-19 |
| title_full_unstemmed | Tamoxifen from chemotherapy to antiviral drug: Possible activity against COVID-19 |
| title_short | Tamoxifen from chemotherapy to antiviral drug: Possible activity against COVID-19 |
| title_sort | tamoxifen from chemotherapy to antiviral drug possible activity against covid 19 |
| topic | antimicrobial agents antiviral drugs chemotherapy coronavirus covid-19 tamoxifen |
| url | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2020;volume=4;issue=2;spage=108;epage=116;aulast=Almosawey |
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