Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma
Abstract The objective of this study was to investigate the clinical significance and roles of tumor progression locus 2 (TPL2) and peptidyl-prolyl cis–trans isomerase 1 (Pin1) in the occurrence and development of breast invasive ductal carcinoma (IDC). Immunohistochemistry was used to detect the ex...
| Үндсэн зохиолчид: | , , , , |
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| Формат: | Өгүүллэг |
| Хэл сонгох: | English |
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Nature Portfolio
2023-10-01
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| Цуврал: | Scientific Reports |
| Онлайн хандалт: | https://doi.org/10.1038/s41598-023-44660-z |
| _version_ | 1827634648371429376 |
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| author | Qin Yu Dan Wan Rong Fu Feng Li Yutao Zhang |
| author_facet | Qin Yu Dan Wan Rong Fu Feng Li Yutao Zhang |
| author_sort | Qin Yu |
| collection | DOAJ |
| description | Abstract The objective of this study was to investigate the clinical significance and roles of tumor progression locus 2 (TPL2) and peptidyl-prolyl cis–trans isomerase 1 (Pin1) in the occurrence and development of breast invasive ductal carcinoma (IDC). Immunohistochemistry was used to detect the expression of TPL2 and Pin1 in human breast tissues, which included normal breast tissues (Normal), tissues with fibrocystic changes (FCC), ductal carcinoma in situ (DCIS), and IDC. The roles of TPL2 and Pin1 in the occurrence and development of IDC, as well as the correlation between their expression levels and clinicopathological parameters, were analyzed. Compared with Normal and FCC groups, the overexpression of TPL2 and Pin1 was significantly increased in DCIS and IDC groups (DCIS vs Normal: P = 0.002/P < 0.001; IDC vs Normal: P = 0.007/P = 0.003; DCIS vs. FCC: P = 0.008/P = 0.004; IDC vs. FCC: P = 0.04/P = 0.043). The expression levels of TPL2 and Pin1 were positively correlated in DCIS and IDC groups (P = 0.001, P = 0.011). In the IDC group, the Ki67 level in the TPL2 overexpression group was significantly lower than that in the TPL2 low expression group (P = 0.02). The TPL2 overexpression rate was significantly higher in IDC with histological grades 1–2 than that in IDC with histological grade 3 (P = 0.029). The TPL2 overexpression rate in IDC with tumor-node-metastasis (TNM) stage I was significantly higher than that in IDC with TNM stages II–III (P = 0.035). We conclude that TPL2 and Pin1 may synergistically promote the occurrence and development of IDC, but TPL2 overexpression may be an early molecular event in IDC development. TPL2 overexpression is significantly related with IDC with lower malignancy or earlier TNM stage, suggesting that the prognosis of IDC patients with TPL2 overexpression may be better and TPL2 overexpression may be a predictor of good prognosis in IDC. |
| first_indexed | 2024-03-09T15:17:13Z |
| format | Article |
| id | doaj.art-0b51fb039cfd4ca187b735a3ff3f78c2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:17:13Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0b51fb039cfd4ca187b735a3ff3f78c22023-11-26T13:00:51ZengNature PortfolioScientific Reports2045-23222023-10-011311810.1038/s41598-023-44660-zOverexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinomaQin Yu0Dan Wan1Rong Fu2Feng Li3Yutao Zhang4Department of Pathology, The First People’s Hospital of ZigongDepartment of Pathology, The First People’s Hospital of ZigongDepartment of Pathology, The First People’s Hospital of ZigongDepartment of Pathology, The First People’s Hospital of ZigongDepartment of Pathology, The First People’s Hospital of ZigongAbstract The objective of this study was to investigate the clinical significance and roles of tumor progression locus 2 (TPL2) and peptidyl-prolyl cis–trans isomerase 1 (Pin1) in the occurrence and development of breast invasive ductal carcinoma (IDC). Immunohistochemistry was used to detect the expression of TPL2 and Pin1 in human breast tissues, which included normal breast tissues (Normal), tissues with fibrocystic changes (FCC), ductal carcinoma in situ (DCIS), and IDC. The roles of TPL2 and Pin1 in the occurrence and development of IDC, as well as the correlation between their expression levels and clinicopathological parameters, were analyzed. Compared with Normal and FCC groups, the overexpression of TPL2 and Pin1 was significantly increased in DCIS and IDC groups (DCIS vs Normal: P = 0.002/P < 0.001; IDC vs Normal: P = 0.007/P = 0.003; DCIS vs. FCC: P = 0.008/P = 0.004; IDC vs. FCC: P = 0.04/P = 0.043). The expression levels of TPL2 and Pin1 were positively correlated in DCIS and IDC groups (P = 0.001, P = 0.011). In the IDC group, the Ki67 level in the TPL2 overexpression group was significantly lower than that in the TPL2 low expression group (P = 0.02). The TPL2 overexpression rate was significantly higher in IDC with histological grades 1–2 than that in IDC with histological grade 3 (P = 0.029). The TPL2 overexpression rate in IDC with tumor-node-metastasis (TNM) stage I was significantly higher than that in IDC with TNM stages II–III (P = 0.035). We conclude that TPL2 and Pin1 may synergistically promote the occurrence and development of IDC, but TPL2 overexpression may be an early molecular event in IDC development. TPL2 overexpression is significantly related with IDC with lower malignancy or earlier TNM stage, suggesting that the prognosis of IDC patients with TPL2 overexpression may be better and TPL2 overexpression may be a predictor of good prognosis in IDC.https://doi.org/10.1038/s41598-023-44660-z |
| spellingShingle | Qin Yu Dan Wan Rong Fu Feng Li Yutao Zhang Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma Scientific Reports |
| title | Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma |
| title_full | Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma |
| title_fullStr | Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma |
| title_full_unstemmed | Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma |
| title_short | Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma |
| title_sort | overexpression of tpl2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma |
| url | https://doi.org/10.1038/s41598-023-44660-z |
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