Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Risk in Patients with Chronic Kidney Disease without Previous Cardiac Pathology
Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the clonal expansion of hematopoietic stem cells carrying certain genes associated with an increased risk of hematological malignancies. Our study analyzes the influence of CHIP on the risk of heart disease and cardiovascular event...
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MDPI AG
2023-08-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/9/1801 |
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| author | Maria Kislikova Maria Ana Batlle Lopez Francisco Javier Freire Salinas José Antonio Parra Blanco Maria Pilar García-Berbel Molina Alejandro Aguilera Fernandez Vicente Celestino Piñera Haces Maria Teresa García Unzueta Adalberto Benito Hernández Juan Carlos Ruiz San Millan Emilio Rodrigo Calabia |
| author_facet | Maria Kislikova Maria Ana Batlle Lopez Francisco Javier Freire Salinas José Antonio Parra Blanco Maria Pilar García-Berbel Molina Alejandro Aguilera Fernandez Vicente Celestino Piñera Haces Maria Teresa García Unzueta Adalberto Benito Hernández Juan Carlos Ruiz San Millan Emilio Rodrigo Calabia |
| author_sort | Maria Kislikova |
| collection | DOAJ |
| description | Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the clonal expansion of hematopoietic stem cells carrying certain genes associated with an increased risk of hematological malignancies. Our study analyzes the influence of CHIP on the risk of heart disease and cardiovascular events in a population with chronic kidney disease (CKD). A total of 128 patients were prospectively followed up for 18 months to detect major cardiovascular events (MACE). To detect the presence of silent heart disease, troponin I, NT-Pro-BNP, and coronary calcification were measured. A massive sequencing was performed to detect CHIP. A total of 24.2% of the patients presented CHIP, including that which was only pathogenic. The most frequently affected gene was TET2 (21.1%). Using multivariate logistic regression analysis, the presence of CHIP was not related to coronary calcification (OR 0.387, 95% CI 0.142–1.058, <i>p</i> = 0.387), nor was it related to troponin I or NT-Pro-BNP. A total of nine patients developed major cardiovascular events. Patients with CHIP did not have a higher risk of major cardiovascular events, although patients with DNMT3A did have a higher risk (HR 6.637, 95% CI 1.443–30.533, <i>p</i> = 0.015), independent of other variables. We did not find that CHIP was associated with a greater risk of silent heart disease or cardiovascular events, although those affected by DNMT3a, analyzed independently, were associated with a greater number of cardiovascular events. |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T22:32:37Z |
| publishDate | 2023-08-01 |
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| series | Life |
| spelling | doaj.art-0b5303b603024f32a9593d3c6b5c670e2023-11-19T11:36:29ZengMDPI AGLife2075-17292023-08-01139180110.3390/life13091801Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Risk in Patients with Chronic Kidney Disease without Previous Cardiac PathologyMaria Kislikova0Maria Ana Batlle Lopez1Francisco Javier Freire Salinas2José Antonio Parra Blanco3Maria Pilar García-Berbel Molina4Alejandro Aguilera Fernandez5Vicente Celestino Piñera Haces6Maria Teresa García Unzueta7Adalberto Benito Hernández8Juan Carlos Ruiz San Millan9Emilio Rodrigo Calabia10Immunopathology Group, Nephrology Department, Marqués de Valdecilla University Hospital—IDIVAL, 39009 Santander, SpainHematology Department, Marqués de Valdecilla University Hospital—IDIVAL, 39009 Santander, SpainPathology Department, Marqués de Valdecilla University Hospital—IDIVAL, 39009 Santander, SpainRadiology Department, Marqués de Valdecilla University Hospital—IDIVAL, 39009 Santander, SpainPathology Department, Marqués de Valdecilla University Hospital—IDIVAL, 39009 Santander, SpainImmunopathology Group, Nephrology Department, Marqués de Valdecilla University Hospital—IDIVAL, 39009 Santander, SpainImmunopathology Group, Nephrology Department, Marqués de Valdecilla University Hospital—IDIVAL, 39009 Santander, SpainClinical Laboratory Department, Marqués de Valdecilla University Hospital—IDIVAL, 39009 Santander, SpainImmunopathology Group, Nephrology Department, Marqués de Valdecilla University Hospital—IDIVAL, 39009 Santander, SpainImmunopathology Group, Nephrology Department, Marqués de Valdecilla University Hospital—IDIVAL, 39009 Santander, SpainImmunopathology Group, Nephrology Department, Marqués de Valdecilla University Hospital—IDIVAL, 39009 Santander, SpainClonal hematopoiesis of indeterminate potential (CHIP) is defined by the clonal expansion of hematopoietic stem cells carrying certain genes associated with an increased risk of hematological malignancies. Our study analyzes the influence of CHIP on the risk of heart disease and cardiovascular events in a population with chronic kidney disease (CKD). A total of 128 patients were prospectively followed up for 18 months to detect major cardiovascular events (MACE). To detect the presence of silent heart disease, troponin I, NT-Pro-BNP, and coronary calcification were measured. A massive sequencing was performed to detect CHIP. A total of 24.2% of the patients presented CHIP, including that which was only pathogenic. The most frequently affected gene was TET2 (21.1%). Using multivariate logistic regression analysis, the presence of CHIP was not related to coronary calcification (OR 0.387, 95% CI 0.142–1.058, <i>p</i> = 0.387), nor was it related to troponin I or NT-Pro-BNP. A total of nine patients developed major cardiovascular events. Patients with CHIP did not have a higher risk of major cardiovascular events, although patients with DNMT3A did have a higher risk (HR 6.637, 95% CI 1.443–30.533, <i>p</i> = 0.015), independent of other variables. We did not find that CHIP was associated with a greater risk of silent heart disease or cardiovascular events, although those affected by DNMT3a, analyzed independently, were associated with a greater number of cardiovascular events.https://www.mdpi.com/2075-1729/13/9/1801coronary artery calcificationheart diseasechronic kidney diseasemajor adverse cardiovascular eventsclonal hematopoiesis of indeterminate potentialcardiovascular risk |
| spellingShingle | Maria Kislikova Maria Ana Batlle Lopez Francisco Javier Freire Salinas José Antonio Parra Blanco Maria Pilar García-Berbel Molina Alejandro Aguilera Fernandez Vicente Celestino Piñera Haces Maria Teresa García Unzueta Adalberto Benito Hernández Juan Carlos Ruiz San Millan Emilio Rodrigo Calabia Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Risk in Patients with Chronic Kidney Disease without Previous Cardiac Pathology Life coronary artery calcification heart disease chronic kidney disease major adverse cardiovascular events clonal hematopoiesis of indeterminate potential cardiovascular risk |
| title | Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Risk in Patients with Chronic Kidney Disease without Previous Cardiac Pathology |
| title_full | Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Risk in Patients with Chronic Kidney Disease without Previous Cardiac Pathology |
| title_fullStr | Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Risk in Patients with Chronic Kidney Disease without Previous Cardiac Pathology |
| title_full_unstemmed | Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Risk in Patients with Chronic Kidney Disease without Previous Cardiac Pathology |
| title_short | Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Risk in Patients with Chronic Kidney Disease without Previous Cardiac Pathology |
| title_sort | clonal hematopoiesis of indeterminate potential and cardiovascular risk in patients with chronic kidney disease without previous cardiac pathology |
| topic | coronary artery calcification heart disease chronic kidney disease major adverse cardiovascular events clonal hematopoiesis of indeterminate potential cardiovascular risk |
| url | https://www.mdpi.com/2075-1729/13/9/1801 |
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