Cortical Auditory Evoked Potentials in Cognitive Impairment and Their Relevance to Hearing Loss: A Systematic Review Highlighting the Evidence Gap
Background: Alzheimer’s disease (AD) is the most prevalent cause of dementia which affects a growing number of people worldwide. Early identification of people at risk to develop AD should be prioritized. Hearing loss is considered an independent potentially modifiable risk factor for accelerated co...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.781322/full |
| _version_ | 1818927635041878016 |
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| author | Hanne Gommeren Hanne Gommeren Joyce Bosmans Emilie Cardon Emilie Cardon Griet Mertens Griet Mertens Patrick Cras Patrick Cras Sebastiaan Engelborghs Sebastiaan Engelborghs Angelique Van Ombergen Annick Gilles Annick Gilles Annick Gilles Marc Lammers Marc Lammers Vincent Van Rompaey Vincent Van Rompaey |
| author_facet | Hanne Gommeren Hanne Gommeren Joyce Bosmans Emilie Cardon Emilie Cardon Griet Mertens Griet Mertens Patrick Cras Patrick Cras Sebastiaan Engelborghs Sebastiaan Engelborghs Angelique Van Ombergen Annick Gilles Annick Gilles Annick Gilles Marc Lammers Marc Lammers Vincent Van Rompaey Vincent Van Rompaey |
| author_sort | Hanne Gommeren |
| collection | DOAJ |
| description | Background: Alzheimer’s disease (AD) is the most prevalent cause of dementia which affects a growing number of people worldwide. Early identification of people at risk to develop AD should be prioritized. Hearing loss is considered an independent potentially modifiable risk factor for accelerated cognitive decline and dementia in older adults. The main outcome of interest of this review is the alteration of Cortical Auditory Evoked Potential (CAEP) morphology in an AD or mild cognitive impairment (MCI) population with and without hearing loss.Methods: Two investigators independently and systematically searched publications regarding auditory processing on a cortical level in people with cognitive impairment (MCI or AD) with and without hearing loss. Only articles which mentioned at least one auditory elicited event-related potential (ERP) component and that were written in English or Dutch were included. Animal studies were excluded. No restrictions were imposed regarding publication date. The reference list of potential sources were screened for additional articles.Results: This systematic review found no eligible articles that met all inclusion criteria. Therefore, no results were included, resulting in an empty systematic review.Conclusion: In general, dysfunction – being either from cognitive or auditory origin – reduces CAEP amplitudes and prolongs latencies. Therefore, CAEPs may be a prognostic indicator in the early stages of cognitive decline. However, it remains unclear which CAEP component alteration is due to cognitive impairment, and which is due to hearing loss (or even both). In addition, vestibular dysfunction – associated with hearing loss, cognitive impairment and AD – may also alter CAEP responses. Further CAEP studies are warranted, integrating cognitive, hearing, and vestibular evaluations. |
| first_indexed | 2024-12-20T03:16:08Z |
| format | Article |
| id | doaj.art-0b53083dfeb74b07bb7b04208e432bb7 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-20T03:16:08Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-0b53083dfeb74b07bb7b04208e432bb72022-12-21T19:55:21ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-11-011510.3389/fnins.2021.781322781322Cortical Auditory Evoked Potentials in Cognitive Impairment and Their Relevance to Hearing Loss: A Systematic Review Highlighting the Evidence GapHanne Gommeren0Hanne Gommeren1Joyce Bosmans2Emilie Cardon3Emilie Cardon4Griet Mertens5Griet Mertens6Patrick Cras7Patrick Cras8Sebastiaan Engelborghs9Sebastiaan Engelborghs10Angelique Van Ombergen11Annick Gilles12Annick Gilles13Annick Gilles14Marc Lammers15Marc Lammers16Vincent Van Rompaey17Vincent Van Rompaey18Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Neurology, Antwerp University Hospital and Institute Born-Bunge, University of Antwerp, Antwerp, BelgiumDepartment of Neurology, University Hospital Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, BelgiumDepartment of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumDepartment of Education, Health and Social Work, University College Ghent, Ghent, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumBackground: Alzheimer’s disease (AD) is the most prevalent cause of dementia which affects a growing number of people worldwide. Early identification of people at risk to develop AD should be prioritized. Hearing loss is considered an independent potentially modifiable risk factor for accelerated cognitive decline and dementia in older adults. The main outcome of interest of this review is the alteration of Cortical Auditory Evoked Potential (CAEP) morphology in an AD or mild cognitive impairment (MCI) population with and without hearing loss.Methods: Two investigators independently and systematically searched publications regarding auditory processing on a cortical level in people with cognitive impairment (MCI or AD) with and without hearing loss. Only articles which mentioned at least one auditory elicited event-related potential (ERP) component and that were written in English or Dutch were included. Animal studies were excluded. No restrictions were imposed regarding publication date. The reference list of potential sources were screened for additional articles.Results: This systematic review found no eligible articles that met all inclusion criteria. Therefore, no results were included, resulting in an empty systematic review.Conclusion: In general, dysfunction – being either from cognitive or auditory origin – reduces CAEP amplitudes and prolongs latencies. Therefore, CAEPs may be a prognostic indicator in the early stages of cognitive decline. However, it remains unclear which CAEP component alteration is due to cognitive impairment, and which is due to hearing loss (or even both). In addition, vestibular dysfunction – associated with hearing loss, cognitive impairment and AD – may also alter CAEP responses. Further CAEP studies are warranted, integrating cognitive, hearing, and vestibular evaluations.https://www.frontiersin.org/articles/10.3389/fnins.2021.781322/fullevent related potentials (ERP)cortical auditory evoked potential (CAEP)hearingvestibular functiondementiaAlzheimer’s disease |
| spellingShingle | Hanne Gommeren Hanne Gommeren Joyce Bosmans Emilie Cardon Emilie Cardon Griet Mertens Griet Mertens Patrick Cras Patrick Cras Sebastiaan Engelborghs Sebastiaan Engelborghs Angelique Van Ombergen Annick Gilles Annick Gilles Annick Gilles Marc Lammers Marc Lammers Vincent Van Rompaey Vincent Van Rompaey Cortical Auditory Evoked Potentials in Cognitive Impairment and Their Relevance to Hearing Loss: A Systematic Review Highlighting the Evidence Gap Frontiers in Neuroscience event related potentials (ERP) cortical auditory evoked potential (CAEP) hearing vestibular function dementia Alzheimer’s disease |
| title | Cortical Auditory Evoked Potentials in Cognitive Impairment and Their Relevance to Hearing Loss: A Systematic Review Highlighting the Evidence Gap |
| title_full | Cortical Auditory Evoked Potentials in Cognitive Impairment and Their Relevance to Hearing Loss: A Systematic Review Highlighting the Evidence Gap |
| title_fullStr | Cortical Auditory Evoked Potentials in Cognitive Impairment and Their Relevance to Hearing Loss: A Systematic Review Highlighting the Evidence Gap |
| title_full_unstemmed | Cortical Auditory Evoked Potentials in Cognitive Impairment and Their Relevance to Hearing Loss: A Systematic Review Highlighting the Evidence Gap |
| title_short | Cortical Auditory Evoked Potentials in Cognitive Impairment and Their Relevance to Hearing Loss: A Systematic Review Highlighting the Evidence Gap |
| title_sort | cortical auditory evoked potentials in cognitive impairment and their relevance to hearing loss a systematic review highlighting the evidence gap |
| topic | event related potentials (ERP) cortical auditory evoked potential (CAEP) hearing vestibular function dementia Alzheimer’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.781322/full |
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