Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

<h4>Introduction</h4>Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated using the 3D Rotary Cell Culture...

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Bibliographic Details
Main Authors: Stuart J Smith, Martin Wilson, Jennifer H Ward, Cheryl V Rahman, Andrew C Peet, Donald C Macarthur, Felicity R A J Rose, Richard G Grundy, Ruman Rahman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272238/?tool=EBI

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