Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl <i>s</i>-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (MDA-MB-231) <i>via</i> EGFR/PI3K/AKT/mTOR Signaling Cascades

Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl <i>s</i>-Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (MDA-MB-231) <i>via</i> EGFR/PI3K/AKT/mTOR Signaling Cascades

Here, we described the synthesis of novel pyrazole-<i>s</i>-triazine derivatives via an easy one-pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with <i>N</i>,<i>N</i>-dimethylfo...

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Bibliographic Details
Main Authors: Ihab Shawish, Assem Barakat, Ali Aldalbahi, Walhan Alshaer, Fadwa Daoud, Dana A. Alqudah, Mazhar Al Zoubi, Ma’mon M. Hatmal, Mohamed S. Nafie, Matti Haukka, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio, Ayman El-Faham
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
one-pot synthesis
DMF-DMA
pyrazolyl-<i>s</i>-triazine
anticancer profile
EGFR/PI3K/AKT/mTOR
apoptosis
Online Access:https://www.mdpi.com/1999-4923/14/8/1558

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