THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS
Cell subtypes and cytokine profile of apheresis products collected from lymphoma and acute leucosis patients were analyzed. It was shown, that acute leucosis patients' grafts contained higher relative numbers of naïve T-cells, CD4+CD25high T-cells, T-lymphocytes (non-significant trend) and lowe...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2012-05-01
|
| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/879 |
| _version_ | 1797237662022631424 |
|---|---|
| author | D. S. Baranova L. V. Sakhno I. V. Kruchkova N. V. Pronkina M. A. Tikhonova E. V. Batorov A. V. Gilevich V. V. Sergeyevicheva S. A. Sizikova G. Yu. Ushakova A. A. Ostanin T. I. Pospelova E. R. Chernykh |
| author_facet | D. S. Baranova L. V. Sakhno I. V. Kruchkova N. V. Pronkina M. A. Tikhonova E. V. Batorov A. V. Gilevich V. V. Sergeyevicheva S. A. Sizikova G. Yu. Ushakova A. A. Ostanin T. I. Pospelova E. R. Chernykh |
| author_sort | D. S. Baranova |
| collection | DOAJ |
| description | Cell subtypes and cytokine profile of apheresis products collected from lymphoma and acute leucosis patients were analyzed. It was shown, that acute leucosis patients' grafts contained higher relative numbers of naïve T-cells, CD4+CD25high T-cells, T-lymphocytes (non-significant trend) and lower counts of granulocytes. Significant increase of relative numbers of dividing CD34+ cells (in S, G2/M phases of the cell cycle) was demonstrated, in acute leucosis patients' grafts. In lymphoma grafts the levels of CD34+ cells in G0/G1 phases were found, to be increased. Cells isolated from grafts of acute leucosis patients characterized by higher levels of proinflammatory cytokines production, such as IL-1, IL-6, MIP-1β, TNF-α, IL-8, IFN-γ (the last two ones— non-significant trend) and cytokines, essential for humoral immune response (IL-4 and — in trend — IL-10). The existing differences didn't influence on effectiveness of early lymphocyte recovery. |
| first_indexed | 2024-03-08T12:22:45Z |
| format | Article |
| id | doaj.art-0b5909017ef04dd4ad736063d8431e4a |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:23:18Z |
| publishDate | 2012-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-0b5909017ef04dd4ad736063d8431e4a2024-03-28T07:49:03ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-05-0103(2)2932825THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTSD. S. Baranova0L. V. Sakhno1I. V. Kruchkova2N. V. Pronkina3M. A. Tikhonova4E. V. Batorov5A. V. Gilevich6V. V. Sergeyevicheva7S. A. Sizikova8G. Yu. Ushakova9A. A. Ostanin10T. I. Pospelova11E. R. Chernykh12Federal State Research Institute of Clinical Immunology SB RAMSFederal State Research Institute of Clinical Immunology SB RAMSFederal State Research Institute of Clinical Immunology SB RAMSFederal State Research Institute of Clinical Immunology SB RAMSFederal State Research Institute of Clinical Immunology SB RAMSFederal State Research Institute of Clinical Immunology SB RAMSFederal State Research Institute of Clinical Immunology SB RAMSFederal State Research Institute of Clinical Immunology SB RAMSFederal State Research Institute of Clinical Immunology SB RAMSFederal State Research Institute of Clinical Immunology SB RAMSFederal State Research Institute of Clinical Immunology SB RAMSNovosibirsk State Medical UniversityFederal State Research Institute of Clinical Immunology SB RAMSCell subtypes and cytokine profile of apheresis products collected from lymphoma and acute leucosis patients were analyzed. It was shown, that acute leucosis patients' grafts contained higher relative numbers of naïve T-cells, CD4+CD25high T-cells, T-lymphocytes (non-significant trend) and lower counts of granulocytes. Significant increase of relative numbers of dividing CD34+ cells (in S, G2/M phases of the cell cycle) was demonstrated, in acute leucosis patients' grafts. In lymphoma grafts the levels of CD34+ cells in G0/G1 phases were found, to be increased. Cells isolated from grafts of acute leucosis patients characterized by higher levels of proinflammatory cytokines production, such as IL-1, IL-6, MIP-1β, TNF-α, IL-8, IFN-γ (the last two ones— non-significant trend) and cytokines, essential for humoral immune response (IL-4 and — in trend — IL-10). The existing differences didn't influence on effectiveness of early lymphocyte recovery.https://www.actabiomedica.ru/jour/article/view/879autologous hematopoietic stem cell transplantationapheresis product |
| spellingShingle | D. S. Baranova L. V. Sakhno I. V. Kruchkova N. V. Pronkina M. A. Tikhonova E. V. Batorov A. V. Gilevich V. V. Sergeyevicheva S. A. Sizikova G. Yu. Ushakova A. A. Ostanin T. I. Pospelova E. R. Chernykh THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS Acta Biomedica Scientifica autologous hematopoietic stem cell transplantation apheresis product |
| title | THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS |
| title_full | THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS |
| title_fullStr | THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS |
| title_full_unstemmed | THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS |
| title_short | THE COMPARATIVE ANALYSIS OF GRAFT CELL SUBTYPES AND ITS CYTOKINE PRODUCTION OF LYMPHOMA AND LEUCOSIS PATIENTS |
| title_sort | comparative analysis of graft cell subtypes and its cytokine production of lymphoma and leucosis patients |
| topic | autologous hematopoietic stem cell transplantation apheresis product |
| url | https://www.actabiomedica.ru/jour/article/view/879 |
| work_keys_str_mv | AT dsbaranova thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT lvsakhno thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT ivkruchkova thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT nvpronkina thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT matikhonova thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT evbatorov thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT avgilevich thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT vvsergeyevicheva thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT sasizikova thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT gyuushakova thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT aaostanin thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT tipospelova thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT erchernykh thecomparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT dsbaranova comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT lvsakhno comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT ivkruchkova comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT nvpronkina comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT matikhonova comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT evbatorov comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT avgilevich comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT vvsergeyevicheva comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT sasizikova comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT gyuushakova comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT aaostanin comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT tipospelova comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients AT erchernykh comparativeanalysisofgraftcellsubtypesanditscytokineproductionoflymphomaandleucosispatients |