Comparative analysis between fasting and postprandial apolipoprotein B and total cholesterol/high-density lipoprotein-cholesterol ratio for atherosclerosis risk prediction in type 2 diabetes mellitus subjects of central India
Background: Type 2 diabetes mellitus (Type 2 DM), characterized by a relative insulin deficiency or insulin resistance, is associated with a cluster of metabolic abnormalities, which includes glucose intolerance, hypertension, a unique dyslipidemia, a procoagulant state, and an increase in macrovasc...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-03-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/50196 |
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| author | Rajesh K Jambhulkar Suryabhan L Lokhande Praveen K Salame Ashok K Ahirwar |
| author_facet | Rajesh K Jambhulkar Suryabhan L Lokhande Praveen K Salame Ashok K Ahirwar |
| author_sort | Rajesh K Jambhulkar |
| collection | DOAJ |
| description | Background: Type 2 diabetes mellitus (Type 2 DM), characterized by a relative insulin deficiency or insulin resistance, is associated with a cluster of metabolic abnormalities, which includes glucose intolerance, hypertension, a unique dyslipidemia, a procoagulant state, and an increase in macrovascular diseases.
Aims and Objectives: The present study was conducted to correlate between fasting and postprandial apolipoprotein B and total cholesterol/high-density lipoprotein-cholesterol (TC/HDL-C) ratio for predicting the risk of atherosclerosis in T2DM subjects.
Materials and Methods: Sixty clinically diagnosed cases of T2DM (age group of 35–65 years and duration of diabetes of more than 5 years) were included in the study and sixty age- and sex-matched healthy subjects were taken as the controls. In both the study groups, we measured postprandial as well as fasting lipid profile, which comprised serum TC, triglycerides (TGs), HDL-C, low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B. Ratio is calculated as TC/HDL-C in both fasting and postprandial state. The statistical analysis was done using the students unpaired’-test.
Results: The results of the present study showed significantly increased levels of postprandial serum TC, TGs, LDL-C, and apo B as compared to those in the fasting state (P<0.05). The serum HDL-C level was significantly lower in the postprandial state as compared to that in the fasting state (P<0.05). Postprandial TC/HDL-C and apo B are increased significantly as compared to fasting condition in type 2 diabetes subjects.
Conclusion: The findings suggest that postprandial lipid profile, apolipoprotein B, and TC/HDL-C ratio as a cardiovascular risk factor can be utilized as simple marker utilizing simple parameters in lipid profile that significantly increased in the postprandial state.Thus, Apolipoprotein B, the marker of the number of LDL particles (for atherosclerosis) in the circulation and TC/HDL-C ratio can be routinely estimated for the atherosclerosis risk assessment in type 2 diabetes subjects in the postprandial state. |
| first_indexed | 2024-04-10T06:22:22Z |
| format | Article |
| id | doaj.art-0b592ffd444f48c49074137949742502 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-10T06:22:22Z |
| publishDate | 2023-03-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-0b592ffd444f48c490741379497425022023-03-02T01:17:44ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-03-01143103109https://doi.org/10.3126/ajms.v14i3.50196Comparative analysis between fasting and postprandial apolipoprotein B and total cholesterol/high-density lipoprotein-cholesterol ratio for atherosclerosis risk prediction in type 2 diabetes mellitus subjects of central IndiaRajesh K Jambhulkar 0https://orcid.org/0000-0001-9170-9434Suryabhan L Lokhande 1https://orcid.org/0000-0002-2571-8735Praveen K Salame 2https://orcid.org/0000-0003-1198-8870Ashok K Ahirwar 3https://orcid.org/0000-0003-3371-378XAssociate Professor, Department of Biochemistry, Government Medical College, Jalgaon, Maharashtra Assistant Professor, Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh Asssitant Professor, Department of General Medicine, IGMC, Nagpur, Maharashtra Assistant Professor, Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India Background: Type 2 diabetes mellitus (Type 2 DM), characterized by a relative insulin deficiency or insulin resistance, is associated with a cluster of metabolic abnormalities, which includes glucose intolerance, hypertension, a unique dyslipidemia, a procoagulant state, and an increase in macrovascular diseases. Aims and Objectives: The present study was conducted to correlate between fasting and postprandial apolipoprotein B and total cholesterol/high-density lipoprotein-cholesterol (TC/HDL-C) ratio for predicting the risk of atherosclerosis in T2DM subjects. Materials and Methods: Sixty clinically diagnosed cases of T2DM (age group of 35–65 years and duration of diabetes of more than 5 years) were included in the study and sixty age- and sex-matched healthy subjects were taken as the controls. In both the study groups, we measured postprandial as well as fasting lipid profile, which comprised serum TC, triglycerides (TGs), HDL-C, low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B. Ratio is calculated as TC/HDL-C in both fasting and postprandial state. The statistical analysis was done using the students unpaired’-test. Results: The results of the present study showed significantly increased levels of postprandial serum TC, TGs, LDL-C, and apo B as compared to those in the fasting state (P<0.05). The serum HDL-C level was significantly lower in the postprandial state as compared to that in the fasting state (P<0.05). Postprandial TC/HDL-C and apo B are increased significantly as compared to fasting condition in type 2 diabetes subjects. Conclusion: The findings suggest that postprandial lipid profile, apolipoprotein B, and TC/HDL-C ratio as a cardiovascular risk factor can be utilized as simple marker utilizing simple parameters in lipid profile that significantly increased in the postprandial state.Thus, Apolipoprotein B, the marker of the number of LDL particles (for atherosclerosis) in the circulation and TC/HDL-C ratio can be routinely estimated for the atherosclerosis risk assessment in type 2 diabetes subjects in the postprandial state.https://www.nepjol.info/index.php/AJMS/article/view/50196type 2 diabetes mellitus; postprandial; total cholesterol; high-density lipoprotein ratio; apolipoprotein b; cardiovascular diseases |
| spellingShingle | Rajesh K Jambhulkar Suryabhan L Lokhande Praveen K Salame Ashok K Ahirwar Comparative analysis between fasting and postprandial apolipoprotein B and total cholesterol/high-density lipoprotein-cholesterol ratio for atherosclerosis risk prediction in type 2 diabetes mellitus subjects of central India Asian Journal of Medical Sciences type 2 diabetes mellitus; postprandial; total cholesterol; high-density lipoprotein ratio; apolipoprotein b; cardiovascular diseases |
| title | Comparative analysis between fasting and postprandial apolipoprotein B and total cholesterol/high-density lipoprotein-cholesterol ratio for atherosclerosis risk prediction in type 2 diabetes mellitus subjects of central India |
| title_full | Comparative analysis between fasting and postprandial apolipoprotein B and total cholesterol/high-density lipoprotein-cholesterol ratio for atherosclerosis risk prediction in type 2 diabetes mellitus subjects of central India |
| title_fullStr | Comparative analysis between fasting and postprandial apolipoprotein B and total cholesterol/high-density lipoprotein-cholesterol ratio for atherosclerosis risk prediction in type 2 diabetes mellitus subjects of central India |
| title_full_unstemmed | Comparative analysis between fasting and postprandial apolipoprotein B and total cholesterol/high-density lipoprotein-cholesterol ratio for atherosclerosis risk prediction in type 2 diabetes mellitus subjects of central India |
| title_short | Comparative analysis between fasting and postprandial apolipoprotein B and total cholesterol/high-density lipoprotein-cholesterol ratio for atherosclerosis risk prediction in type 2 diabetes mellitus subjects of central India |
| title_sort | comparative analysis between fasting and postprandial apolipoprotein b and total cholesterol high density lipoprotein cholesterol ratio for atherosclerosis risk prediction in type 2 diabetes mellitus subjects of central india |
| topic | type 2 diabetes mellitus; postprandial; total cholesterol; high-density lipoprotein ratio; apolipoprotein b; cardiovascular diseases |
| url | https://www.nepjol.info/index.php/AJMS/article/view/50196 |
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