Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004
The food supply, including poultry products, may transmit antimicrobial drug–resistant Escherichia coli to humans. To assess this hypothesis, 931 geographically and temporally matched E. coli isolates from human volunteers (hospital inpatients and healthy vegetarians) and commercial poultry products...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2007-06-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/13/6/06-1576_article |
| _version_ | 1811280334353858560 |
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| author | James R. Johnson Mark R. Sannes Cynthia Croy Brian Johnston Connie Clabots Michael A. Kuskowski Jeff Bender Kirk E. Smith Patricia L. Winokur Edward A. Belongia |
| author_facet | James R. Johnson Mark R. Sannes Cynthia Croy Brian Johnston Connie Clabots Michael A. Kuskowski Jeff Bender Kirk E. Smith Patricia L. Winokur Edward A. Belongia |
| author_sort | James R. Johnson |
| collection | DOAJ |
| description | The food supply, including poultry products, may transmit antimicrobial drug–resistant Escherichia coli to humans. To assess this hypothesis, 931 geographically and temporally matched E. coli isolates from human volunteers (hospital inpatients and healthy vegetarians) and commercial poultry products (conventionally raised or raised without antimicrobial drugs) were tested by PCR for phylogenetic group (A, B1, B2, D) and 60 virulence genes associated with extraintestinal pathogenic E. coli. Isolates resistant to trimethoprim-sulfamethoxazole, quinolones, and extended-spectrum cephalosporins (n = 331) were compared with drug-susceptible isolates (n = 600) stratified by source. Phylogenetic and virulence markers of drug-susceptible human isolates differed considerably from those of human and poultry isolates. In contrast, drug-resistant human isolates were similar to poultry isolates, and drug-susceptible and drug-resistant poultry isolates were largely indistinguishable. Many drug-resistant human fecal E. coli isolates may originate from poultry, whereas drug-resistant poultry-source E. coli isolates likely originate from susceptible poultry-source precursors. |
| first_indexed | 2024-04-13T01:11:48Z |
| format | Article |
| id | doaj.art-0b5b7e948e0b4d57bfa623f168e66602 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-13T01:11:48Z |
| publishDate | 2007-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-0b5b7e948e0b4d57bfa623f168e666022022-12-22T03:09:07ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592007-06-0113683883810.3201/eid1306.061576Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004James R. JohnsonMark R. SannesCynthia CroyBrian JohnstonConnie ClabotsMichael A. KuskowskiJeff BenderKirk E. SmithPatricia L. WinokurEdward A. BelongiaThe food supply, including poultry products, may transmit antimicrobial drug–resistant Escherichia coli to humans. To assess this hypothesis, 931 geographically and temporally matched E. coli isolates from human volunteers (hospital inpatients and healthy vegetarians) and commercial poultry products (conventionally raised or raised without antimicrobial drugs) were tested by PCR for phylogenetic group (A, B1, B2, D) and 60 virulence genes associated with extraintestinal pathogenic E. coli. Isolates resistant to trimethoprim-sulfamethoxazole, quinolones, and extended-spectrum cephalosporins (n = 331) were compared with drug-susceptible isolates (n = 600) stratified by source. Phylogenetic and virulence markers of drug-susceptible human isolates differed considerably from those of human and poultry isolates. In contrast, drug-resistant human isolates were similar to poultry isolates, and drug-susceptible and drug-resistant poultry isolates were largely indistinguishable. Many drug-resistant human fecal E. coli isolates may originate from poultry, whereas drug-resistant poultry-source E. coli isolates likely originate from susceptible poultry-source precursors.https://wwwnc.cdc.gov/eid/article/13/6/06-1576_articleEscherichia coli infectionsantimicrobial drug resistancevirulencephylogeneticsPCRmolecular fingerprinting |
| spellingShingle | James R. Johnson Mark R. Sannes Cynthia Croy Brian Johnston Connie Clabots Michael A. Kuskowski Jeff Bender Kirk E. Smith Patricia L. Winokur Edward A. Belongia Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004 Emerging Infectious Diseases Escherichia coli infections antimicrobial drug resistance virulence phylogenetics PCR molecular fingerprinting |
| title | Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004 |
| title_full | Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004 |
| title_fullStr | Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004 |
| title_full_unstemmed | Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004 |
| title_short | Antimicrobial Drug–Resistant Escherichia coli from Humans and Poultry Products, Minnesota and Wisconsin, 2002–2004 |
| title_sort | antimicrobial drug resistant escherichia coli from humans and poultry products minnesota and wisconsin 2002 2004 |
| topic | Escherichia coli infections antimicrobial drug resistance virulence phylogenetics PCR molecular fingerprinting |
| url | https://wwwnc.cdc.gov/eid/article/13/6/06-1576_article |
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