Design of 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells

Design of 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells

Abstract Infections by Clostridioides difficile, a bacterium that targets the large intestine (colon), impact a large number of people worldwide. Bacterial colonization is mediated by two exotoxins: toxins A and B. Short peptides that can be delivered to the gut and inhibit the biocatalytic activity...

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Bibliographic Details
Main Authors:	Sudeep Sarma, Carly M. Catella, Ellyce T. San Pedro, Xingqing Xiao, Deniz Durmusoglu, Stefano Menegatti, Nathan Crook, Scott T. Magness, Carol K. Hall
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-08-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-023-05242-x

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