Evaluation of Carbomer, CMC and HPMC on Dissolution and Bioadhesion of buccoadhesive Cinnamaldehyde Tablets
Background and purpose: Transmucosal drug delivery unlike oral drug delivery has some advantages including deletion of first past effect and prevention of drug removal in gastro-intestinal tract and enzymatic flora. This study aimed at evaluating the effect of CMC, cerbomer and HPMC on Cinnamaldehyd...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2018-02-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-10475-en.html |
| _version_ | 1797943757856833536 |
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| author | Majid Saeedi Jafar Akbari Katayoon Morteza-semnani Sohrab Rostamkalaei Fatemeh Fathalinejad Elnaz Khoshvishkaie |
| author_facet | Majid Saeedi Jafar Akbari Katayoon Morteza-semnani Sohrab Rostamkalaei Fatemeh Fathalinejad Elnaz Khoshvishkaie |
| author_sort | Majid Saeedi |
| collection | DOAJ |
| description | Background and purpose: Transmucosal drug delivery unlike oral drug delivery has some advantages including deletion of first past effect and prevention of drug removal in gastro-intestinal tract and enzymatic flora. This study aimed at evaluating the effect of CMC, cerbomer and HPMC on Cinnamaldehyde release from formulation matrix and mucoadhesion of these formulations.
Materials and methods: In this experimental research, nine formulations were selected and several tests including flowability, compressibility, hardness, assay, friability, swelling, and bioadhesive force were done.
Results: According to the study, the angles of repose for all formulations were between 20.06±1.67 and 31.93±2.44. In addition, F5 and F6 had the most regular drug release patterns while F8 and F9 were found to have the fastest drug release. Maximum bioadhesive strength was observed in F8 and F9 but the minimum was observed in F3 and F4.
Conclusion: Drug delivery studies are of great importance, particularly for the drugs that do not have therapeutic efficacy in other routs of administration. According to current findings, HPMC induces the best formulation for transmucosal drug delivery. |
| first_indexed | 2024-04-10T20:28:10Z |
| format | Article |
| id | doaj.art-0b5ec28ca1c8447182e727a4509788f2 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:28:10Z |
| publishDate | 2018-02-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-0b5ec28ca1c8447182e727a4509788f22023-01-25T07:42:25ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792018-02-01271577082Evaluation of Carbomer, CMC and HPMC on Dissolution and Bioadhesion of buccoadhesive Cinnamaldehyde TabletsMajid Saeedi0Jafar Akbari1Katayoon Morteza-semnani2Sohrab Rostamkalaei3Fatemeh Fathalinejad4Elnaz Khoshvishkaie5 Professor, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Professor, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Professor, Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Pharmaceutical Sciences Resident, Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Pharmacy Student, Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Pharmacy Student, Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: Transmucosal drug delivery unlike oral drug delivery has some advantages including deletion of first past effect and prevention of drug removal in gastro-intestinal tract and enzymatic flora. This study aimed at evaluating the effect of CMC, cerbomer and HPMC on Cinnamaldehyde release from formulation matrix and mucoadhesion of these formulations. Materials and methods: In this experimental research, nine formulations were selected and several tests including flowability, compressibility, hardness, assay, friability, swelling, and bioadhesive force were done. Results: According to the study, the angles of repose for all formulations were between 20.06±1.67 and 31.93±2.44. In addition, F5 and F6 had the most regular drug release patterns while F8 and F9 were found to have the fastest drug release. Maximum bioadhesive strength was observed in F8 and F9 but the minimum was observed in F3 and F4. Conclusion: Drug delivery studies are of great importance, particularly for the drugs that do not have therapeutic efficacy in other routs of administration. According to current findings, HPMC induces the best formulation for transmucosal drug delivery.http://jmums.mazums.ac.ir/article-1-10475-en.htmlcinnamaldehydemucoadhesivepolymerformulationtransmucosal drug delivery |
| spellingShingle | Majid Saeedi Jafar Akbari Katayoon Morteza-semnani Sohrab Rostamkalaei Fatemeh Fathalinejad Elnaz Khoshvishkaie Evaluation of Carbomer, CMC and HPMC on Dissolution and Bioadhesion of buccoadhesive Cinnamaldehyde Tablets Journal of Mazandaran University of Medical Sciences cinnamaldehyde mucoadhesive polymer formulation transmucosal drug delivery |
| title | Evaluation of Carbomer, CMC and HPMC on Dissolution and Bioadhesion of buccoadhesive Cinnamaldehyde Tablets |
| title_full | Evaluation of Carbomer, CMC and HPMC on Dissolution and Bioadhesion of buccoadhesive Cinnamaldehyde Tablets |
| title_fullStr | Evaluation of Carbomer, CMC and HPMC on Dissolution and Bioadhesion of buccoadhesive Cinnamaldehyde Tablets |
| title_full_unstemmed | Evaluation of Carbomer, CMC and HPMC on Dissolution and Bioadhesion of buccoadhesive Cinnamaldehyde Tablets |
| title_short | Evaluation of Carbomer, CMC and HPMC on Dissolution and Bioadhesion of buccoadhesive Cinnamaldehyde Tablets |
| title_sort | evaluation of carbomer cmc and hpmc on dissolution and bioadhesion of buccoadhesive cinnamaldehyde tablets |
| topic | cinnamaldehyde mucoadhesive polymer formulation transmucosal drug delivery |
| url | http://jmums.mazums.ac.ir/article-1-10475-en.html |
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