The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection
As the recent outbreak of SARS-CoV-2 has highlighted, the threat of a pandemic event from zoonotic viruses, such as the deadly influenza A/H7N9 virus subtype, continues to be a major global health concern. H7N9 virus strains appear to exhibit greater disease severity in mammalian hosts compared to n...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.559113/full |
| _version_ | 1818319651972579328 |
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| author | William S. J. Horman William S. J. Horman Thi H. O. Nguyen Katherine Kedzierska Jeffrey Butler Songhua Shan Rachel Layton John Bingham Jean Payne Andrew G. D. Bean Daniel S. Layton |
| author_facet | William S. J. Horman William S. J. Horman Thi H. O. Nguyen Katherine Kedzierska Jeffrey Butler Songhua Shan Rachel Layton John Bingham Jean Payne Andrew G. D. Bean Daniel S. Layton |
| author_sort | William S. J. Horman |
| collection | DOAJ |
| description | As the recent outbreak of SARS-CoV-2 has highlighted, the threat of a pandemic event from zoonotic viruses, such as the deadly influenza A/H7N9 virus subtype, continues to be a major global health concern. H7N9 virus strains appear to exhibit greater disease severity in mammalian hosts compared to natural avian hosts, though the exact mechanisms underlying this are somewhat unclear. Knowledge of the H7N9 host-pathogen interactions have mainly been constrained to natural sporadic human infections. To elucidate the cellular immune mechanisms associated with disease severity and progression, we used a ferret model to closely resemble disease outcomes in humans following influenza virus infection. Intriguingly, we observed variable disease outcomes when ferrets were inoculated with the A/Anhui/1/2013 (H7N9) strain. We observed relatively reduced antigen-presenting cell activation in lymphoid tissues which may be correlative with increased disease severity. Additionally, depletions in CD8+ T cells were not apparent in sick animals. This study provides further insight into the ways that lymphocytes maturate and traffic in response to H7N9 infection in the ferret model. |
| first_indexed | 2024-12-13T10:12:31Z |
| format | Article |
| id | doaj.art-0b5fadfc9a9a4be5b9f27dac8090b2e4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T10:12:31Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0b5fadfc9a9a4be5b9f27dac8090b2e42022-12-21T23:51:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.559113559113The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus InfectionWilliam S. J. Horman0William S. J. Horman1Thi H. O. Nguyen2Katherine Kedzierska3Jeffrey Butler4Songhua Shan5Rachel Layton6John Bingham7Jean Payne8Andrew G. D. Bean9Daniel S. Layton10Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, AustraliaCommonwealth Scientific and Industrial Research Organisation Health and Biosecurity, Australian Centre for Disease Prevention, East Geelong, VIC, AustraliaDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, AustraliaDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, AustraliaCommonwealth Scientific and Industrial Research Organisation, Australian Centre for Disease Prevention, East Geelong, VIC, AustraliaCommonwealth Scientific and Industrial Research Organisation, Australian Centre for Disease Prevention, East Geelong, VIC, AustraliaCommonwealth Scientific and Industrial Research Organisation, Australian Centre for Disease Prevention, East Geelong, VIC, AustraliaCommonwealth Scientific and Industrial Research Organisation, Australian Centre for Disease Prevention, East Geelong, VIC, AustraliaCommonwealth Scientific and Industrial Research Organisation, Australian Centre for Disease Prevention, East Geelong, VIC, AustraliaCommonwealth Scientific and Industrial Research Organisation Health and Biosecurity, Australian Centre for Disease Prevention, East Geelong, VIC, AustraliaCommonwealth Scientific and Industrial Research Organisation Health and Biosecurity, Australian Centre for Disease Prevention, East Geelong, VIC, AustraliaAs the recent outbreak of SARS-CoV-2 has highlighted, the threat of a pandemic event from zoonotic viruses, such as the deadly influenza A/H7N9 virus subtype, continues to be a major global health concern. H7N9 virus strains appear to exhibit greater disease severity in mammalian hosts compared to natural avian hosts, though the exact mechanisms underlying this are somewhat unclear. Knowledge of the H7N9 host-pathogen interactions have mainly been constrained to natural sporadic human infections. To elucidate the cellular immune mechanisms associated with disease severity and progression, we used a ferret model to closely resemble disease outcomes in humans following influenza virus infection. Intriguingly, we observed variable disease outcomes when ferrets were inoculated with the A/Anhui/1/2013 (H7N9) strain. We observed relatively reduced antigen-presenting cell activation in lymphoid tissues which may be correlative with increased disease severity. Additionally, depletions in CD8+ T cells were not apparent in sick animals. This study provides further insight into the ways that lymphocytes maturate and traffic in response to H7N9 infection in the ferret model.https://www.frontiersin.org/article/10.3389/fimmu.2020.559113/fullinfluenzaH7N9ferretsantigen presenting cellsanimal modelzoonoses |
| spellingShingle | William S. J. Horman William S. J. Horman Thi H. O. Nguyen Katherine Kedzierska Jeffrey Butler Songhua Shan Rachel Layton John Bingham Jean Payne Andrew G. D. Bean Daniel S. Layton The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection Frontiers in Immunology influenza H7N9 ferrets antigen presenting cells animal model zoonoses |
| title | The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection |
| title_full | The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection |
| title_fullStr | The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection |
| title_full_unstemmed | The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection |
| title_short | The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection |
| title_sort | dynamics of the ferret immune response during h7n9 influenza virus infection |
| topic | influenza H7N9 ferrets antigen presenting cells animal model zoonoses |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.559113/full |
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