L-DOPA Improves Ventilation but Not the Ventilatory Response to Hypercapnia in a Reserpine Model of Parkinson’s Disease
Parkinson’s disease (PD) is a neurological disorder characterized by progressive degeneration of the substantia nigra that affects mainly movement control. However, pathological changes associated with the development of PD may also alter respiration and can lead to chronic episodes of hypoxia and h...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/13/5/775 |
| _version_ | 1797600821877145600 |
|---|---|
| author | Monika Jampolska Kryspin Andrzejewski Paweł M. Boguszewski Katarzyna Kaczyńska |
| author_facet | Monika Jampolska Kryspin Andrzejewski Paweł M. Boguszewski Katarzyna Kaczyńska |
| author_sort | Monika Jampolska |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a neurological disorder characterized by progressive degeneration of the substantia nigra that affects mainly movement control. However, pathological changes associated with the development of PD may also alter respiration and can lead to chronic episodes of hypoxia and hypercapnia. The mechanism behind impaired ventilation in PD is unclear. Therefore, in this study, we explore the hypercapnic ventilatory response in a reproducible reserpine-induced (RES) model of PD and parkinsonism. We also investigated how dopamine supplementation with L-DOPA, a classic drug used to treat PD, would affect the breathing and respiratory response to hypercapnia. Reserpine treatment resulted in decreased normocapnic ventilation and behavioral changes manifested as low physical activity and exploratory behavior. The respiratory rate and the minute ventilation response to hypercapnia were significantly higher in sham rats compared to the RES group, while the tidal volume response was lower. All of this appears to be due to reduced baseline ventilation values produced by reserpine. L-DOPA reversed reduced ventilation, indicating a stimulatory effect of DA on breathing, and showed the potency of DA supplementation in restoring normal respiratory activity. |
| first_indexed | 2024-03-11T03:53:25Z |
| format | Article |
| id | doaj.art-0b619eaec6c94c5cb50d38d47596ae40 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T03:53:25Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-0b619eaec6c94c5cb50d38d47596ae402023-11-18T00:42:38ZengMDPI AGBrain Sciences2076-34252023-05-0113577510.3390/brainsci13050775L-DOPA Improves Ventilation but Not the Ventilatory Response to Hypercapnia in a Reserpine Model of Parkinson’s DiseaseMonika Jampolska0Kryspin Andrzejewski1Paweł M. Boguszewski2Katarzyna Kaczyńska3Department of Respiration Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawińskiego 5 St., 02-106 Warsaw, PolandDepartment of Respiration Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawińskiego 5 St., 02-106 Warsaw, PolandLaboratory of Animal Models, Neurobiology Centre, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Ludwika Pasteura 3 St., 02-093 Warsaw, PolandDepartment of Respiration Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawińskiego 5 St., 02-106 Warsaw, PolandParkinson’s disease (PD) is a neurological disorder characterized by progressive degeneration of the substantia nigra that affects mainly movement control. However, pathological changes associated with the development of PD may also alter respiration and can lead to chronic episodes of hypoxia and hypercapnia. The mechanism behind impaired ventilation in PD is unclear. Therefore, in this study, we explore the hypercapnic ventilatory response in a reproducible reserpine-induced (RES) model of PD and parkinsonism. We also investigated how dopamine supplementation with L-DOPA, a classic drug used to treat PD, would affect the breathing and respiratory response to hypercapnia. Reserpine treatment resulted in decreased normocapnic ventilation and behavioral changes manifested as low physical activity and exploratory behavior. The respiratory rate and the minute ventilation response to hypercapnia were significantly higher in sham rats compared to the RES group, while the tidal volume response was lower. All of this appears to be due to reduced baseline ventilation values produced by reserpine. L-DOPA reversed reduced ventilation, indicating a stimulatory effect of DA on breathing, and showed the potency of DA supplementation in restoring normal respiratory activity.https://www.mdpi.com/2076-3425/13/5/775Parkinson’s diseasereserpineL-DOPArat modelbreathinghypercapnia |
| spellingShingle | Monika Jampolska Kryspin Andrzejewski Paweł M. Boguszewski Katarzyna Kaczyńska L-DOPA Improves Ventilation but Not the Ventilatory Response to Hypercapnia in a Reserpine Model of Parkinson’s Disease Brain Sciences Parkinson’s disease reserpine L-DOPA rat model breathing hypercapnia |
| title | L-DOPA Improves Ventilation but Not the Ventilatory Response to Hypercapnia in a Reserpine Model of Parkinson’s Disease |
| title_full | L-DOPA Improves Ventilation but Not the Ventilatory Response to Hypercapnia in a Reserpine Model of Parkinson’s Disease |
| title_fullStr | L-DOPA Improves Ventilation but Not the Ventilatory Response to Hypercapnia in a Reserpine Model of Parkinson’s Disease |
| title_full_unstemmed | L-DOPA Improves Ventilation but Not the Ventilatory Response to Hypercapnia in a Reserpine Model of Parkinson’s Disease |
| title_short | L-DOPA Improves Ventilation but Not the Ventilatory Response to Hypercapnia in a Reserpine Model of Parkinson’s Disease |
| title_sort | l dopa improves ventilation but not the ventilatory response to hypercapnia in a reserpine model of parkinson s disease |
| topic | Parkinson’s disease reserpine L-DOPA rat model breathing hypercapnia |
| url | https://www.mdpi.com/2076-3425/13/5/775 |
| work_keys_str_mv | AT monikajampolska ldopaimprovesventilationbutnottheventilatoryresponsetohypercapniainareserpinemodelofparkinsonsdisease AT kryspinandrzejewski ldopaimprovesventilationbutnottheventilatoryresponsetohypercapniainareserpinemodelofparkinsonsdisease AT pawełmboguszewski ldopaimprovesventilationbutnottheventilatoryresponsetohypercapniainareserpinemodelofparkinsonsdisease AT katarzynakaczynska ldopaimprovesventilationbutnottheventilatoryresponsetohypercapniainareserpinemodelofparkinsonsdisease |