Processing and Bypass of a Site-Specific DNA Adduct of the Cytotoxic Platinum–Acridinylthiourea Conjugate by Polymerases Involved in DNA Repair: Biochemical and Thermodynamic Aspects

Processing and Bypass of a Site-Specific DNA Adduct of the Cytotoxic Platinum–Acridinylthiourea Conjugate by Polymerases Involved in DNA Repair: Biochemical and Thermodynamic Aspects

DNA-dependent DNA and RNA polymerases are important modulators of biological functions such as replication, transcription, recombination, or repair. In this work performed in cell-free media, we studied the ability of selected DNA polymerases to overcome a monofunctional adduct of the cytotoxic/anti...

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Bibliographic Details
Main Authors: Monika Hreusova, Viktor Brabec, Olga Novakova
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
cytotoxic
antitumor
platinum–acridine
lesion bypass
DNA polymerases
thermodynamic
Online Access:https://www.mdpi.com/1422-0067/22/19/10838

Internet

https://www.mdpi.com/1422-0067/22/19/10838

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