Risk and countermeasure of laboratory-acquired infection based on pathogen transmission routes

Laboratory-acquired infection (LAI) is an important issue in laboratory biosafety for pathogenic microorganism, which aims to prevent the spread of infectious pathogens and protect laboratory personnel from potentially harmful microorganisms. Previous LAI reports provided a source of information for...

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Main Authors: Kunlan Zuo, Zongzhen Wu, Chihong Zhao, Huan Liu
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Biosafety and Health
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590053623000502
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author Kunlan Zuo
Zongzhen Wu
Chihong Zhao
Huan Liu
author_facet Kunlan Zuo
Zongzhen Wu
Chihong Zhao
Huan Liu
author_sort Kunlan Zuo
collection DOAJ
description Laboratory-acquired infection (LAI) is an important issue in laboratory biosafety for pathogenic microorganism, which aims to prevent the spread of infectious pathogens and protect laboratory personnel from potentially harmful microorganisms. Previous LAI reports provided a source of information for understanding the transmission routes and therapies helping to develop targeted prevention and response programs and to comprehensively ensure the biosafety of laboratories. In this study, from the perspective of the transmission routes of agents, the biosafety risks were discussed from four aspects: skin, eye, or mucous membrane exposure, contaminated sharp inoculation or bites from infected animals and arthropod vectors, ingestion or hand-to-mouth exposure, and inhalation of infectious aerosols. The development and evolution of LAI were reviewed, and appropriate countermeasures and suggestions were proposed accordingly.
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spelling doaj.art-0b6522e38d64452591a473abd462c9512023-06-25T04:43:28ZengElsevierBiosafety and Health2590-05362023-06-0153133137Risk and countermeasure of laboratory-acquired infection based on pathogen transmission routesKunlan Zuo0Zongzhen Wu1Chihong Zhao2Huan Liu3University of Science and Technology of China, Hefei 230026, ChinaUniversity of Science and Technology of China, Hefei 230026, ChinaChinese Center for Disease Control and Prevention, Beijing 102206, ChinaUniversity of Science and Technology of China, Hefei 230026, China; State Key Laboratory of Virology, Wuhan 430072, China; Corresponding author: University of Science and Technology of China, Hefei 230026, China; State Key Laboratory of Virology, Wuhan 430072, China (H. Liu).Laboratory-acquired infection (LAI) is an important issue in laboratory biosafety for pathogenic microorganism, which aims to prevent the spread of infectious pathogens and protect laboratory personnel from potentially harmful microorganisms. Previous LAI reports provided a source of information for understanding the transmission routes and therapies helping to develop targeted prevention and response programs and to comprehensively ensure the biosafety of laboratories. In this study, from the perspective of the transmission routes of agents, the biosafety risks were discussed from four aspects: skin, eye, or mucous membrane exposure, contaminated sharp inoculation or bites from infected animals and arthropod vectors, ingestion or hand-to-mouth exposure, and inhalation of infectious aerosols. The development and evolution of LAI were reviewed, and appropriate countermeasures and suggestions were proposed accordingly.http://www.sciencedirect.com/science/article/pii/S2590053623000502Laboratory-acquired infectionTransmission routeBiosafety
spellingShingle Kunlan Zuo
Zongzhen Wu
Chihong Zhao
Huan Liu
Risk and countermeasure of laboratory-acquired infection based on pathogen transmission routes
Biosafety and Health
Laboratory-acquired infection
Transmission route
Biosafety
title Risk and countermeasure of laboratory-acquired infection based on pathogen transmission routes
title_full Risk and countermeasure of laboratory-acquired infection based on pathogen transmission routes
title_fullStr Risk and countermeasure of laboratory-acquired infection based on pathogen transmission routes
title_full_unstemmed Risk and countermeasure of laboratory-acquired infection based on pathogen transmission routes
title_short Risk and countermeasure of laboratory-acquired infection based on pathogen transmission routes
title_sort risk and countermeasure of laboratory acquired infection based on pathogen transmission routes
topic Laboratory-acquired infection
Transmission route
Biosafety
url http://www.sciencedirect.com/science/article/pii/S2590053623000502
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AT zongzhenwu riskandcountermeasureoflaboratoryacquiredinfectionbasedonpathogentransmissionroutes
AT chihongzhao riskandcountermeasureoflaboratoryacquiredinfectionbasedonpathogentransmissionroutes
AT huanliu riskandcountermeasureoflaboratoryacquiredinfectionbasedonpathogentransmissionroutes