Clinical and epidemiological characteristics of mothers with COVID-19 and their neonates: vertical transmission
Introduction COVID-19 disease can affect women at any stage of pregnancy, and newborns could become infected with SARS-CoV-2 through vertical or horizontal transmission. Objective To determine clinical and epidemiological characteristics of mothers with COVID-19, associated neonatal outcomes, a...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Medwave Estudios Limitada
2021-08-01
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| Series: | Medwave |
| Subjects: | |
| Online Access: | https://www.medwave.cl/link.cgi/Medwave/Estudios/Investigacion/8454.act |
| _version_ | 1818912294581567488 |
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| author | Amalia Guadalupe Vega-Fernández Betty María Zevallos-Vargas Fiorella del Pilar Flores-Figueroa Juan Carlos Holguín-Plasencia Luis Martín Galois Centeno-Fuentes Silvia Antonia Ayquipa-Gil Ramón Alberto Lescano-Alva Karla Patricia Arrasco-Castro Hubert Alberto Alvarado-Herrera William Robert Zafra-Alegre Edgar Jaime Idrogo-Cayotopa Cristian Pierre Reyes-Carranza Leyla Kathy Ramírez-Gamarra Jakelina Glenda Peña-Estrella Angelica María Pardo-Carrasco Susana Andrea Suárez-Rebaza |
| author_facet | Amalia Guadalupe Vega-Fernández Betty María Zevallos-Vargas Fiorella del Pilar Flores-Figueroa Juan Carlos Holguín-Plasencia Luis Martín Galois Centeno-Fuentes Silvia Antonia Ayquipa-Gil Ramón Alberto Lescano-Alva Karla Patricia Arrasco-Castro Hubert Alberto Alvarado-Herrera William Robert Zafra-Alegre Edgar Jaime Idrogo-Cayotopa Cristian Pierre Reyes-Carranza Leyla Kathy Ramírez-Gamarra Jakelina Glenda Peña-Estrella Angelica María Pardo-Carrasco Susana Andrea Suárez-Rebaza |
| author_sort | Amalia Guadalupe Vega-Fernández |
| collection | DOAJ |
| description | Introduction
COVID-19 disease can affect women at any stage of pregnancy, and newborns could become infected with SARS-CoV-2 through vertical or horizontal transmission.
Objective
To determine clinical and epidemiological characteristics of mothers with COVID-19, associated neonatal outcomes, and to evaluate SARS-CoV-2 vertical transmission.
Methods
We conducted an observational, descriptive, cross-sectional study. We included all mothers with positive serology for SARS-CoV-2 and their newborns at the Hospital Regional Docente de Trujillo from April 18 to September 30, 2020. Variables were collected from the medical records, and descriptive statistics were used for the analysis.
Results
A total of 647 mothers and 656 neonates were enrolled. Of all live births, 85.3% and 14.7% were term and preterm neonates, respectively. We found 1.7% (11/656) of newborns with positive RT-PCR for SARS-CoV-2; and that 27.3% (3/11) of these neonates required hospitalization. Neonatal mortality was 4/656 (0.6%), and no case was attributed to COVID-19. Of all mothers affected with COVID-19, 95.7% were asymptomatic, and 4.3% presented clinical symptoms attributed to COVID-19, most of which were mild. The most frequent obstetric complications were preeclampsia-eclampsia, prelabour rupture of membranes, and acute fetal distress. All the mothers were discharged.
Conclusion
We found 1.7% of newborns with positive RT-PCR test for SARS-CoV-2; and that 20.1% of these neonates were hospitalized. The most frequent morbidity was neonatal sepsis and prematurity. The infection was mild among newborns, showing a 0.6% overall mortality, with no cases attributed to COVID-19. We found that only 5% of mothers presented symptoms, most of which were mild to moderate symptoms. There was no record of maternal mortality in this study group. It is not possible to conclude whether vertical transmission or intrapartum-acquired infection is responsible for neonatal COVID-19 infections. |
| first_indexed | 2024-12-19T23:12:19Z |
| format | Article |
| id | doaj.art-0b6b742d012b4798804ee63712f5f9f3 |
| institution | Directory Open Access Journal |
| issn | 0717-6384 |
| language | English |
| last_indexed | 2024-12-19T23:12:19Z |
| publishDate | 2021-08-01 |
| publisher | Medwave Estudios Limitada |
| record_format | Article |
| series | Medwave |
| spelling | doaj.art-0b6b742d012b4798804ee63712f5f9f32022-12-21T20:02:11ZengMedwave Estudios LimitadaMedwave0717-63842021-08-012107e8454e845410.5867/medwave.2021.07.8454Clinical and epidemiological characteristics of mothers with COVID-19 and their neonates: vertical transmissionAmalia Guadalupe Vega-Fernández0Betty María Zevallos-Vargas1Fiorella del Pilar Flores-Figueroa2Juan Carlos Holguín-Plasencia3Luis Martín Galois Centeno-Fuentes4Silvia Antonia Ayquipa-Gil5Ramón Alberto Lescano-Alva6Karla Patricia Arrasco-Castro7Hubert Alberto Alvarado-Herrera8William Robert Zafra-Alegre9Edgar Jaime Idrogo-Cayotopa10Cristian Pierre Reyes-Carranza11Leyla Kathy Ramírez-Gamarra12Jakelina Glenda Peña-Estrella13Angelica María Pardo-Carrasco14Susana Andrea Suárez-Rebaza15Hospital Regional Docente de Trujillo, Trujillo, Perú; Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad César Vallejo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, Perú; Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad César Vallejo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, Perú; Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad César Vallejo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúHospital Regional Docente de Trujillo, Trujillo, PerúIntroduction COVID-19 disease can affect women at any stage of pregnancy, and newborns could become infected with SARS-CoV-2 through vertical or horizontal transmission. Objective To determine clinical and epidemiological characteristics of mothers with COVID-19, associated neonatal outcomes, and to evaluate SARS-CoV-2 vertical transmission. Methods We conducted an observational, descriptive, cross-sectional study. We included all mothers with positive serology for SARS-CoV-2 and their newborns at the Hospital Regional Docente de Trujillo from April 18 to September 30, 2020. Variables were collected from the medical records, and descriptive statistics were used for the analysis. Results A total of 647 mothers and 656 neonates were enrolled. Of all live births, 85.3% and 14.7% were term and preterm neonates, respectively. We found 1.7% (11/656) of newborns with positive RT-PCR for SARS-CoV-2; and that 27.3% (3/11) of these neonates required hospitalization. Neonatal mortality was 4/656 (0.6%), and no case was attributed to COVID-19. Of all mothers affected with COVID-19, 95.7% were asymptomatic, and 4.3% presented clinical symptoms attributed to COVID-19, most of which were mild. The most frequent obstetric complications were preeclampsia-eclampsia, prelabour rupture of membranes, and acute fetal distress. All the mothers were discharged. Conclusion We found 1.7% of newborns with positive RT-PCR test for SARS-CoV-2; and that 20.1% of these neonates were hospitalized. The most frequent morbidity was neonatal sepsis and prematurity. The infection was mild among newborns, showing a 0.6% overall mortality, with no cases attributed to COVID-19. We found that only 5% of mothers presented symptoms, most of which were mild to moderate symptoms. There was no record of maternal mortality in this study group. It is not possible to conclude whether vertical transmission or intrapartum-acquired infection is responsible for neonatal COVID-19 infections.https://www.medwave.cl/link.cgi/Medwave/Estudios/Investigacion/8454.actsars-cov-2vertical infection transmissioninfantnewbornpregnancy complication |
| spellingShingle | Amalia Guadalupe Vega-Fernández Betty María Zevallos-Vargas Fiorella del Pilar Flores-Figueroa Juan Carlos Holguín-Plasencia Luis Martín Galois Centeno-Fuentes Silvia Antonia Ayquipa-Gil Ramón Alberto Lescano-Alva Karla Patricia Arrasco-Castro Hubert Alberto Alvarado-Herrera William Robert Zafra-Alegre Edgar Jaime Idrogo-Cayotopa Cristian Pierre Reyes-Carranza Leyla Kathy Ramírez-Gamarra Jakelina Glenda Peña-Estrella Angelica María Pardo-Carrasco Susana Andrea Suárez-Rebaza Clinical and epidemiological characteristics of mothers with COVID-19 and their neonates: vertical transmission Medwave sars-cov-2 vertical infection transmission infant newborn pregnancy complication |
| title | Clinical and epidemiological characteristics of mothers with COVID-19 and their neonates: vertical transmission |
| title_full | Clinical and epidemiological characteristics of mothers with COVID-19 and their neonates: vertical transmission |
| title_fullStr | Clinical and epidemiological characteristics of mothers with COVID-19 and their neonates: vertical transmission |
| title_full_unstemmed | Clinical and epidemiological characteristics of mothers with COVID-19 and their neonates: vertical transmission |
| title_short | Clinical and epidemiological characteristics of mothers with COVID-19 and their neonates: vertical transmission |
| title_sort | clinical and epidemiological characteristics of mothers with covid 19 and their neonates vertical transmission |
| topic | sars-cov-2 vertical infection transmission infant newborn pregnancy complication |
| url | https://www.medwave.cl/link.cgi/Medwave/Estudios/Investigacion/8454.act |
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