Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols
Polyphenols are micronutrients that are widely present in human daily diets. Numerous studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and for cancer prevention, heart protection and the treatment of neurodegenerative diseases. However, due to their vulnerabili...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/20/4613 |
| _version_ | 1827704594459787264 |
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| author | Bingyan Yang Yixin Dong Fei Wang Yu Zhang |
| author_facet | Bingyan Yang Yixin Dong Fei Wang Yu Zhang |
| author_sort | Bingyan Yang |
| collection | DOAJ |
| description | Polyphenols are micronutrients that are widely present in human daily diets. Numerous studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and for cancer prevention, heart protection and the treatment of neurodegenerative diseases. However, due to their vulnerability to environmental conditions and low bioavailability, their application in the food and medical fields is greatly limited. Nanoformulations, as excellent drug delivery systems, can overcome these limitations and maximize the pharmacological effects of polyphenols. In this review, we summarize the biological activities of polyphenols, together with systems for their delivery, including phospholipid complexes, lipid-based nanoparticles, protein-based nanoparticles, niosomes, polymers, micelles, emulsions and metal nanoparticles. The application of polyphenol nanoparticles in food and medicine is also discussed. Although loading into nanoparticles solves the main limitation to application of polyphenolic compounds, there are some concerns about their toxicological safety after entry into the human body. It is therefore necessary to conduct toxicity studies and residue analysis on the carrier. |
| first_indexed | 2024-03-10T15:44:04Z |
| format | Article |
| id | doaj.art-0b6caf038f4c4a9f905efe38934bd7e9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:44:04Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0b6caf038f4c4a9f905efe38934bd7e92023-11-20T16:33:59ZengMDPI AGMolecules1420-30492020-10-012520461310.3390/molecules25204613Nanoformulations to Enhance the Bioavailability and Physiological Functions of PolyphenolsBingyan Yang0Yixin Dong1Fei Wang2Yu Zhang3Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, ChinaPolyphenols are micronutrients that are widely present in human daily diets. Numerous studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and for cancer prevention, heart protection and the treatment of neurodegenerative diseases. However, due to their vulnerability to environmental conditions and low bioavailability, their application in the food and medical fields is greatly limited. Nanoformulations, as excellent drug delivery systems, can overcome these limitations and maximize the pharmacological effects of polyphenols. In this review, we summarize the biological activities of polyphenols, together with systems for their delivery, including phospholipid complexes, lipid-based nanoparticles, protein-based nanoparticles, niosomes, polymers, micelles, emulsions and metal nanoparticles. The application of polyphenol nanoparticles in food and medicine is also discussed. Although loading into nanoparticles solves the main limitation to application of polyphenolic compounds, there are some concerns about their toxicological safety after entry into the human body. It is therefore necessary to conduct toxicity studies and residue analysis on the carrier.https://www.mdpi.com/1420-3049/25/20/4613polyphenolsbioavailabilityloadingnanoformulations |
| spellingShingle | Bingyan Yang Yixin Dong Fei Wang Yu Zhang Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols Molecules polyphenols bioavailability loading nanoformulations |
| title | Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols |
| title_full | Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols |
| title_fullStr | Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols |
| title_full_unstemmed | Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols |
| title_short | Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols |
| title_sort | nanoformulations to enhance the bioavailability and physiological functions of polyphenols |
| topic | polyphenols bioavailability loading nanoformulations |
| url | https://www.mdpi.com/1420-3049/25/20/4613 |
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