Ivabradine acutely improves cardiac Ca handling and function in a rat model of Duchenne muscular dystrophy

Ivabradine acutely improves cardiac Ca handling and function in a rat model of Duchenne muscular dystrophy

Abstract The muscular dystrophies caused by dystrophin deficiency, the so‐called dystrophinopathies, are associated with impaired cardiac contractility and arrhythmias, which considerably contribute to disease morbidity and mortality. Impaired Ca handling in ventricular cardiomyocytes has been ident...

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Bibliographic Details
Main Authors: Petra Lujza Szabo, Jessica Marksteiner, Janine Ebner, Christopher Dostal, Bruno K. Podesser, Jakob Sauer, Helmut Kubista, Hannes Todt, Benjamin Hackl, Xaver Koenig, Attila Kiss, Karlheinz Hilber
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Physiological Reports
Subjects:
calcium handling
cardiac function
Duchenne muscular dystrophy
ivabradine
Online Access:https://doi.org/10.14814/phy2.15664

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