Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus
Complementary actions of the neocortex and the hippocampus enable encoding and long-term storage of experience dependent memories. Standard models for memory storage assume that sensory signals reach the hippocampus from superficial layers of the entorhinal cortex (EC). Deep layers of the EC on the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2022-02-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/73162 |
| _version_ | 1818026488637685760 |
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| author | Sau Yee Tsoi Merve Öncül Ella Svahn Mark Robertson Zuzanna Bogdanowicz Christina McClure Gülşen Sürmeli |
| author_facet | Sau Yee Tsoi Merve Öncül Ella Svahn Mark Robertson Zuzanna Bogdanowicz Christina McClure Gülşen Sürmeli |
| author_sort | Sau Yee Tsoi |
| collection | DOAJ |
| description | Complementary actions of the neocortex and the hippocampus enable encoding and long-term storage of experience dependent memories. Standard models for memory storage assume that sensory signals reach the hippocampus from superficial layers of the entorhinal cortex (EC). Deep layers of the EC on the other hand relay hippocampal outputs to the telencephalic structures including many parts of the neocortex. Here, we show that cells in layer 5a of the medial EC send a copy of their telencephalic outputs back to the CA1 region of the hippocampus. Combining cell-type-specific anatomical tracing with high-throughput RNA-sequencing based projection mapping and optogenetics aided circuit mapping, we show that in the mouse brain these projections have a unique topography and target hippocampal pyramidal cells and interneurons. Our results suggest that projections of deep medial EC neurons are anatomically configured to influence the hippocampus and neocortex simultaneously and therefore lead to novel hypotheses on the functional role of the deep EC. |
| first_indexed | 2024-12-10T04:32:48Z |
| format | Article |
| id | doaj.art-0b6ef7e324554b7290c9e3b6e07d83ba |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T04:32:48Z |
| publishDate | 2022-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-0b6ef7e324554b7290c9e3b6e07d83ba2022-12-22T02:02:05ZengeLife Sciences Publications LtdeLife2050-084X2022-02-011110.7554/eLife.73162Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampusSau Yee Tsoi0Merve Öncül1Ella Svahn2Mark Robertson3Zuzanna Bogdanowicz4Christina McClure5Gülşen Sürmeli6https://orcid.org/0000-0002-3227-0641University of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, United KingdomUniversity of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, United KingdomUniversity of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, United KingdomUniversity of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, United KingdomUniversity of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, United KingdomUniversity of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, United KingdomUniversity of Edinburgh, Centre for Discovery Brain Sciences, Edinburgh, United Kingdom; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, United KingdomComplementary actions of the neocortex and the hippocampus enable encoding and long-term storage of experience dependent memories. Standard models for memory storage assume that sensory signals reach the hippocampus from superficial layers of the entorhinal cortex (EC). Deep layers of the EC on the other hand relay hippocampal outputs to the telencephalic structures including many parts of the neocortex. Here, we show that cells in layer 5a of the medial EC send a copy of their telencephalic outputs back to the CA1 region of the hippocampus. Combining cell-type-specific anatomical tracing with high-throughput RNA-sequencing based projection mapping and optogenetics aided circuit mapping, we show that in the mouse brain these projections have a unique topography and target hippocampal pyramidal cells and interneurons. Our results suggest that projections of deep medial EC neurons are anatomically configured to influence the hippocampus and neocortex simultaneously and therefore lead to novel hypotheses on the functional role of the deep EC.https://elifesciences.org/articles/73162neural circuitshippocampusentorhinal cortexmemoryfeedbacklayer 5 |
| spellingShingle | Sau Yee Tsoi Merve Öncül Ella Svahn Mark Robertson Zuzanna Bogdanowicz Christina McClure Gülşen Sürmeli Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus eLife neural circuits hippocampus entorhinal cortex memory feedback layer 5 |
| title | Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus |
| title_full | Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus |
| title_fullStr | Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus |
| title_full_unstemmed | Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus |
| title_short | Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus |
| title_sort | telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus |
| topic | neural circuits hippocampus entorhinal cortex memory feedback layer 5 |
| url | https://elifesciences.org/articles/73162 |
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