Retroviral Vectors: Post Entry Events and Genomic Alterations

Retroviral Vectors: Post Entry Events and Genomic Alterations

The curative potential of retroviral vectors for somatic gene therapy has been demonstrated impressively in several clinical trials leading to sustained long-term correction of the underlying genetic defect. Preclinical studies and clinical monitoring of gene modified hematopoietic stem and progenit...

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Bibliographic Details
Main Authors: Christof von Kalle, Manfred Schmidt, Hanno Glimm, Ali Nowrouzi
Format: Article
Language:English
Published: MDPI AG 2011-04-01
Series:Viruses
Subjects:
retroviral vectors
retroviral integration
gene therapy
insertional mutagenesis
vector genotoxicity
Leukemia
common insertion sites
Online Access:http://www.mdpi.com/1999-4915/3/5/429/

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