Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders

Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders

Genetic primary immunodeficiency diseases are increasingly recognized, with pathogenic mutations changing the composition of circulating leukocyte subsets measured by flow cytometry (FCM). Discerning changes in multiple subpopulations is challenging, and subtle trends might be missed if traditional...

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Bibliographic Details
Main Authors: Julia I. Ellyard, Robert Tunningley, Ayla May Lorenzo, Simon H. Jiang, Amelia Cook, Rochna Chand, Dipti Talaulikar, Ann-Maree Hatch, Anastasia Wilson, Carola G. Vinuesa, Matthew C. Cook, David A. Fulcher
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
flow cytometry
immunodeficiency
common variable immunodeficiency
TACI
CTLA4
TNFSF13B
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02134/full

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