Acetyl genistin modulates myotube differentiation and attenuates dexamethasone-induced muscle atrophy through the FoxO1/3 signaling pathway in C2C12 myotubes

Acetyl genistin modulates myotube differentiation and attenuates dexamethasone-induced muscle atrophy through the FoxO1/3 signaling pathway in C2C12 myotubes

Abstract Muscle atrophy, a debilitating condition characterized by loss of muscle mass and strength, is a major concern in various clinical settings. Acetyl genistin (AG), a bioactive compound, was evaluated for its role in muscle cell differentiation and its potential protective effects against dex...

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Bibliographic Details
Main Authors: Won Min Jeong, Seung-Jin Kwag, Jun Young Ha, Seung-Jun Lee, Yeong-In Choe, Dong Yeol Lee, Dong Kyu Jeong, Hwan Hee Bae, Jin-Hee Seo, Young-Sool Hah, Sang Gon Kim
Format: Article
Language:English
Published: SpringerOpen 2024-03-01
Series:Applied Biological Chemistry
Subjects:
Acetyl genistin
Dexamethasone
Muscle atrophy
MAFbx
MuRF1
FoxO
Online Access:https://doi.org/10.1186/s13765-024-00885-8

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