Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats

Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats

Sepsis increases glucocorticoid and decreases IGF-1, leading to skeletal muscle wasting and cachexia. Muscle atrophy mainly takes place in locomotor muscles rather than in respiratory ones. Our study aimed to elucidate the mechanism responsible for this difference in muscle proteolysis, focusing on...

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Bibliographic Details
Main Authors: Álvaro Moreno-Rupérez, Teresa Priego, María Ángeles González-Nicolás, Asunción López-Calderón, Alberto Lázaro, Ana Isabel Martín
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
sepsis
inflammation
muscle wasting
glucocorticoids signaling
HDAC4-myogenin
IGF-1
Online Access:https://www.mdpi.com/1422-0067/23/7/3641

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