Psoriasis and the risk of pneumonia: a population-based study.
<h4>Background</h4>Psoriasis is a prevalent autoimmune disorder. Various studies have reported on the relationship between psoriasis and chronic diseases but very few have explored the association between psoriasis and subsequent acute infection. This retrospective cohort study aimed to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0116077 |
| _version_ | 1819143842682634240 |
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| author | Li-Ting Kao Cha-Ze Lee Shih-Ping Liu Ming-Chieh Tsai Herng-Ching Lin |
| author_facet | Li-Ting Kao Cha-Ze Lee Shih-Ping Liu Ming-Chieh Tsai Herng-Ching Lin |
| author_sort | Li-Ting Kao |
| collection | DOAJ |
| description | <h4>Background</h4>Psoriasis is a prevalent autoimmune disorder. Various studies have reported on the relationship between psoriasis and chronic diseases but very few have explored the association between psoriasis and subsequent acute infection. This retrospective cohort study aimed to compare the risk of pneumonia between subjects with and those without psoriasis.<h4>Methods</h4>The medical records of 14,022 patients with psoriasis and 14,022 without psoriasis were obtained from the Taiwan Longitudinal Health Insurance Database 2000. Each patient was followed-up for a three-year period. Cox proportional hazard regressions were performed to compare difference of subsequent pneumonia incidence between subjects with and those without psoriasis.<h4>Results</h4>There were 206 (1.47%) subjects with psoriasis and 138 (0.98%) without psoriasis hospitalized for pneumonia. By Cox proportional hazard regressions analysis, the HR (hazard ratio) of pneumonia requiring hospitalization for patients with psoriasis was 1.50 (95% confidence interval [CI]: 1.21-1.86) compared to patients without psoriasis. The adjusted HR was 1.40 (95% CI: 1.12-1.73). The adjusted HR of pneumonia hospitalization for subjects with mild and severe psoriasis was 1.36 (95% CI: 1.09-1.70) and 1.68 (95% CI: 1.12-2.52), respectively, compared to those without psoriasis.<h4>Conclusions</h4>Patients with psoriasis have significantly higher incidence of pneumonia compared to those without psoriasis. |
| first_indexed | 2024-12-22T12:32:40Z |
| format | Article |
| id | doaj.art-0b735b99adf84d70aaf7c6981dddd4c5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T12:32:40Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0b735b99adf84d70aaf7c6981dddd4c52022-12-21T18:25:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11607710.1371/journal.pone.0116077Psoriasis and the risk of pneumonia: a population-based study.Li-Ting KaoCha-Ze LeeShih-Ping LiuMing-Chieh TsaiHerng-Ching Lin<h4>Background</h4>Psoriasis is a prevalent autoimmune disorder. Various studies have reported on the relationship between psoriasis and chronic diseases but very few have explored the association between psoriasis and subsequent acute infection. This retrospective cohort study aimed to compare the risk of pneumonia between subjects with and those without psoriasis.<h4>Methods</h4>The medical records of 14,022 patients with psoriasis and 14,022 without psoriasis were obtained from the Taiwan Longitudinal Health Insurance Database 2000. Each patient was followed-up for a three-year period. Cox proportional hazard regressions were performed to compare difference of subsequent pneumonia incidence between subjects with and those without psoriasis.<h4>Results</h4>There were 206 (1.47%) subjects with psoriasis and 138 (0.98%) without psoriasis hospitalized for pneumonia. By Cox proportional hazard regressions analysis, the HR (hazard ratio) of pneumonia requiring hospitalization for patients with psoriasis was 1.50 (95% confidence interval [CI]: 1.21-1.86) compared to patients without psoriasis. The adjusted HR was 1.40 (95% CI: 1.12-1.73). The adjusted HR of pneumonia hospitalization for subjects with mild and severe psoriasis was 1.36 (95% CI: 1.09-1.70) and 1.68 (95% CI: 1.12-2.52), respectively, compared to those without psoriasis.<h4>Conclusions</h4>Patients with psoriasis have significantly higher incidence of pneumonia compared to those without psoriasis.https://doi.org/10.1371/journal.pone.0116077 |
| spellingShingle | Li-Ting Kao Cha-Ze Lee Shih-Ping Liu Ming-Chieh Tsai Herng-Ching Lin Psoriasis and the risk of pneumonia: a population-based study. PLoS ONE |
| title | Psoriasis and the risk of pneumonia: a population-based study. |
| title_full | Psoriasis and the risk of pneumonia: a population-based study. |
| title_fullStr | Psoriasis and the risk of pneumonia: a population-based study. |
| title_full_unstemmed | Psoriasis and the risk of pneumonia: a population-based study. |
| title_short | Psoriasis and the risk of pneumonia: a population-based study. |
| title_sort | psoriasis and the risk of pneumonia a population based study |
| url | https://doi.org/10.1371/journal.pone.0116077 |
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