Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma
Abstract Background Reconstruction of soft tissue defects following surgical tumor resection is important for quality of life in cancer patients with oral and oropharyngeal squamous cell carcinoma (SCC). This study presents a novel computer-aided reconstruction of soft tissue (CARST) technology empl...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-06-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-022-02654-7 |
| _version_ | 1811241237525561344 |
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| author | Jiajie Xu Fangyuan Lai Yunfeng Liu Zhuo Tan Chuanming Zheng Jiafeng Wang Haiwei Guo Liehao Jiang Xinyang Ge Xiabin Lan Chao Chen Minghua Ge |
| author_facet | Jiajie Xu Fangyuan Lai Yunfeng Liu Zhuo Tan Chuanming Zheng Jiafeng Wang Haiwei Guo Liehao Jiang Xinyang Ge Xiabin Lan Chao Chen Minghua Ge |
| author_sort | Jiajie Xu |
| collection | DOAJ |
| description | Abstract Background Reconstruction of soft tissue defects following surgical tumor resection is important for quality of life in cancer patients with oral and oropharyngeal squamous cell carcinoma (SCC). This study presents a novel computer-aided reconstruction of soft tissue (CARST) technology employed with these patients. Methods We first described the CARST technology in detail in a report of a 34-year-old male patient with locally invasive right-sided tongue SCC following a nearly total glossectomy and reported the postoperative outcomes. This digital technology was applied to construct a 3D model from CT images, which was used to delineate surgical resection boundaries and design a personalized reconstruction of the soft tissue defect. A nonuniform rational B-spline (NURBS) was generated and applied to transform the 3D model into a 2D flap-cutting guide printed out using a 3D printer. We then reported a case-series study on oral and oropharyngeal SCC patients who were randomly assigned to receive the CARST (n = 15) or a traditional soft tissue reconstruction (n = 15). Clinicopathological features and short- and long-term postoperative outcomes between the two groups were compared. Results The patient with the tongue SCC had a successful CARST following surgical tumor resection without any complications. His speech and swallowing functions recovered well after surgery and he experienced no significant changes to his appearance following recovery. There was no recurrence within a 3-year follow-up period. Results of the case-series study showed that the CARST group had significantly shorter operative and post-operation hospital-stay time, a higher flap utilization rate, and a trend of less and milder postoperative complications, and they experienced no significant difference in intraoperative blood loss and long-term outcomes compared to the traditional group. Conclusion CARST is a safer and more efficient personalized technology of soft tissue reconstruction following surgical tumor resection in patients with oral and oropharyngeal SCC. |
| first_indexed | 2024-04-12T13:32:34Z |
| format | Article |
| id | doaj.art-0b741fbdd91c4c3fb83262da6dbf1495 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-12T13:32:34Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-0b741fbdd91c4c3fb83262da6dbf14952022-12-22T03:31:07ZengBMCWorld Journal of Surgical Oncology1477-78192022-06-0120111010.1186/s12957-022-02654-7Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinomaJiajie Xu0Fangyuan Lai1Yunfeng Liu2Zhuo Tan3Chuanming Zheng4Jiafeng Wang5Haiwei Guo6Liehao Jiang7Xinyang Ge8Xiabin Lan9Chao Chen10Minghua Ge11Otolaryngology& Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Center for Plastic & Reconstructive Surgery, Department of Plastic & Reconstructive Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Key Laboratory of E&M, Zhejiang University of Technology, Ministry of Education & Zhejiang ProvinceOtolaryngology& Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Otolaryngology& Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Otolaryngology& Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Otolaryngology& Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Otolaryngology& Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)College of Letters and Science, University of California, Los AngelesDepartment of Head and Neck Surgery, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer HospitalDepartment of Head and Neck Surgery, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer HospitalOtolaryngology& Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Abstract Background Reconstruction of soft tissue defects following surgical tumor resection is important for quality of life in cancer patients with oral and oropharyngeal squamous cell carcinoma (SCC). This study presents a novel computer-aided reconstruction of soft tissue (CARST) technology employed with these patients. Methods We first described the CARST technology in detail in a report of a 34-year-old male patient with locally invasive right-sided tongue SCC following a nearly total glossectomy and reported the postoperative outcomes. This digital technology was applied to construct a 3D model from CT images, which was used to delineate surgical resection boundaries and design a personalized reconstruction of the soft tissue defect. A nonuniform rational B-spline (NURBS) was generated and applied to transform the 3D model into a 2D flap-cutting guide printed out using a 3D printer. We then reported a case-series study on oral and oropharyngeal SCC patients who were randomly assigned to receive the CARST (n = 15) or a traditional soft tissue reconstruction (n = 15). Clinicopathological features and short- and long-term postoperative outcomes between the two groups were compared. Results The patient with the tongue SCC had a successful CARST following surgical tumor resection without any complications. His speech and swallowing functions recovered well after surgery and he experienced no significant changes to his appearance following recovery. There was no recurrence within a 3-year follow-up period. Results of the case-series study showed that the CARST group had significantly shorter operative and post-operation hospital-stay time, a higher flap utilization rate, and a trend of less and milder postoperative complications, and they experienced no significant difference in intraoperative blood loss and long-term outcomes compared to the traditional group. Conclusion CARST is a safer and more efficient personalized technology of soft tissue reconstruction following surgical tumor resection in patients with oral and oropharyngeal SCC.https://doi.org/10.1186/s12957-022-02654-7Oral and oropharyngealTongueSquamous cell carcinoma (SCC)Anterolateral thigh flap (ALTF)Computer-aided reconstruction of soft tissue (CARST) |
| spellingShingle | Jiajie Xu Fangyuan Lai Yunfeng Liu Zhuo Tan Chuanming Zheng Jiafeng Wang Haiwei Guo Liehao Jiang Xinyang Ge Xiabin Lan Chao Chen Minghua Ge Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma World Journal of Surgical Oncology Oral and oropharyngeal Tongue Squamous cell carcinoma (SCC) Anterolateral thigh flap (ALTF) Computer-aided reconstruction of soft tissue (CARST) |
| title | Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma |
| title_full | Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma |
| title_fullStr | Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma |
| title_full_unstemmed | Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma |
| title_short | Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma |
| title_sort | novel computer aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma |
| topic | Oral and oropharyngeal Tongue Squamous cell carcinoma (SCC) Anterolateral thigh flap (ALTF) Computer-aided reconstruction of soft tissue (CARST) |
| url | https://doi.org/10.1186/s12957-022-02654-7 |
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