Does double dose of recombinant human chorionic gonadotropin for final follicular maturation in in vitro fertilization cycles improve oocyte quality: A prospective randomized study
Context: In in vitro fertilization (IVF) cycles, the recommended dose of recombinant human chorionic gonadotropin (r-hCG), for triggering final follicular maturation is 250 μg, although there is some disagreement. Aims: The aim of our study was to assess the effect on the number of mature oocytes re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=4;spage=310;epage=315;aulast=Singh |
| _version_ | 1818292587143888896 |
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| author | Neeta Singh Bhavana Girish Neena Malhotra Reeta Mahey Vanamail Perumal |
| author_facet | Neeta Singh Bhavana Girish Neena Malhotra Reeta Mahey Vanamail Perumal |
| author_sort | Neeta Singh |
| collection | DOAJ |
| description | Context: In in vitro fertilization (IVF) cycles, the recommended dose of recombinant human chorionic gonadotropin (r-hCG), for triggering final follicular maturation is 250 μg, although there is some disagreement. Aims: The aim of our study was to assess the effect on the number of mature oocytes retrieved after triggering ovulation in IVF cycles using 250 μg or 500 μg of r-hCG. Settings and Design: Prospective, single-center, randomized study. Subjects and Methods: 100 women undergoing IVF with embryo transfer. The primary outcome measure was the total number of oocytes retrieved per follicle, number of mature oocytes, and number of embryos generated. The secondary outcomes included clinical and biochemical pregnancy rates and incidence of ovarian hyperstimulation syndrome. Results: Mean number of oocytes retrieved (6.5 ± 4.0 vs. 6.4 ± 3.9, P = 0.3) and mean number of mature oocytes (4.0 ± 2.3 vs. 3.2 ± 2.3, P = 0.09) were similar in the two groups; however, mean number of oocytes retrieved per follicle was found to be higher with 500 μg r-hCG (67.4 ± 23.9 vs. 77.5 ± 23.3, P = 0.04). In the subgroup of poor responder women, there was a significant increase in the number of mature oocytes retrieved with double dose of r-hCG (2.2 ± 1.8 vs. 3.7 ± 1.9, P = 0.06), leading to improvement in fertilization and clinical pregnancy rates. Conclusions: Double dose of r-hCG for final follicular maturation in IVF cycles resulted in improvement in mean number of oocytes per follicle but did not result in improved pregnancy rates in the women. In the subset of poor responders, 500 μg r-hCG seems to be more advantageous than the lower dose, although larger randomized trials are needed to generalize this strategy. |
| first_indexed | 2024-12-13T03:02:20Z |
| format | Article |
| id | doaj.art-0b74efafa0c046b1800c65e3946cb55f |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-13T03:02:20Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-0b74efafa0c046b1800c65e3946cb55f2022-12-22T00:01:47ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662019-01-0112431031510.4103/jhrs.JHRS_125_18Does double dose of recombinant human chorionic gonadotropin for final follicular maturation in in vitro fertilization cycles improve oocyte quality: A prospective randomized studyNeeta SinghBhavana GirishNeena MalhotraReeta MaheyVanamail PerumalContext: In in vitro fertilization (IVF) cycles, the recommended dose of recombinant human chorionic gonadotropin (r-hCG), for triggering final follicular maturation is 250 μg, although there is some disagreement. Aims: The aim of our study was to assess the effect on the number of mature oocytes retrieved after triggering ovulation in IVF cycles using 250 μg or 500 μg of r-hCG. Settings and Design: Prospective, single-center, randomized study. Subjects and Methods: 100 women undergoing IVF with embryo transfer. The primary outcome measure was the total number of oocytes retrieved per follicle, number of mature oocytes, and number of embryos generated. The secondary outcomes included clinical and biochemical pregnancy rates and incidence of ovarian hyperstimulation syndrome. Results: Mean number of oocytes retrieved (6.5 ± 4.0 vs. 6.4 ± 3.9, P = 0.3) and mean number of mature oocytes (4.0 ± 2.3 vs. 3.2 ± 2.3, P = 0.09) were similar in the two groups; however, mean number of oocytes retrieved per follicle was found to be higher with 500 μg r-hCG (67.4 ± 23.9 vs. 77.5 ± 23.3, P = 0.04). In the subgroup of poor responder women, there was a significant increase in the number of mature oocytes retrieved with double dose of r-hCG (2.2 ± 1.8 vs. 3.7 ± 1.9, P = 0.06), leading to improvement in fertilization and clinical pregnancy rates. Conclusions: Double dose of r-hCG for final follicular maturation in IVF cycles resulted in improvement in mean number of oocytes per follicle but did not result in improved pregnancy rates in the women. In the subset of poor responders, 500 μg r-hCG seems to be more advantageous than the lower dose, although larger randomized trials are needed to generalize this strategy.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=4;spage=310;epage=315;aulast=Singhin vitro fertilizationin vitro fertilization outcomesmature oocytespoor responderrecombinant-human chorionic gonadotropin trigger |
| spellingShingle | Neeta Singh Bhavana Girish Neena Malhotra Reeta Mahey Vanamail Perumal Does double dose of recombinant human chorionic gonadotropin for final follicular maturation in in vitro fertilization cycles improve oocyte quality: A prospective randomized study Journal of Human Reproductive Sciences in vitro fertilization in vitro fertilization outcomes mature oocytes poor responder recombinant-human chorionic gonadotropin trigger |
| title | Does double dose of recombinant human chorionic gonadotropin for final follicular maturation in in vitro fertilization cycles improve oocyte quality: A prospective randomized study |
| title_full | Does double dose of recombinant human chorionic gonadotropin for final follicular maturation in in vitro fertilization cycles improve oocyte quality: A prospective randomized study |
| title_fullStr | Does double dose of recombinant human chorionic gonadotropin for final follicular maturation in in vitro fertilization cycles improve oocyte quality: A prospective randomized study |
| title_full_unstemmed | Does double dose of recombinant human chorionic gonadotropin for final follicular maturation in in vitro fertilization cycles improve oocyte quality: A prospective randomized study |
| title_short | Does double dose of recombinant human chorionic gonadotropin for final follicular maturation in in vitro fertilization cycles improve oocyte quality: A prospective randomized study |
| title_sort | does double dose of recombinant human chorionic gonadotropin for final follicular maturation in in vitro fertilization cycles improve oocyte quality a prospective randomized study |
| topic | in vitro fertilization in vitro fertilization outcomes mature oocytes poor responder recombinant-human chorionic gonadotropin trigger |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=4;spage=310;epage=315;aulast=Singh |
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