Sirt1 overexpression attenuates Western‐style diet‐induced aortic stiffening in mice

Sirt1 overexpression attenuates Western‐style diet‐induced aortic stiffening in mice

Abstract Increased arterial stiffness is a cardiovascular disease risk factor in the setting of advancing age and Western diet (WD) induced obesity. Increases in large artery stiffness, as measured by pulse wave velocity (PWV), occur within 8 weeks of WD feeding in mice. Sirtuin‐1 (Sirt1), a NAD‐dep...

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Bibliographic Details
Main Authors: Venkateswara R. Gogulamudi, Daniel R. Machin, Grant D. Henson, Jisok Lim, Richard C. Bramwell, Jessica R. Durrant, Anthony J. Donato, Lisa A. Lesniewski
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Physiological Reports
Subjects:
aorta
arterial stiffness
Sirt1
sirtuins
Western diet
Online Access:https://doi.org/10.14814/phy2.15284

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