Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
It is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04674-y |
| _version_ | 1818992811044765696 |
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| author | Christophe Chopard Phuoc Bao Viet Tong Petra Tóth Malvina Schatz Hocine Yezid Solène Debaisieux Clément Mettling Antoine Gross Martine Pugnière Annie Tu Jean-Marc Strub Jean-Michel Mesnard Nicolas Vitale Bruno Beaumelle |
| author_facet | Christophe Chopard Phuoc Bao Viet Tong Petra Tóth Malvina Schatz Hocine Yezid Solène Debaisieux Clément Mettling Antoine Gross Martine Pugnière Annie Tu Jean-Marc Strub Jean-Michel Mesnard Nicolas Vitale Bruno Beaumelle |
| author_sort | Christophe Chopard |
| collection | DOAJ |
| description | It is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane. |
| first_indexed | 2024-12-20T20:32:05Z |
| format | Article |
| id | doaj.art-0b76da00f3d140a9bf12b239560dc94a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:32:05Z |
| publishDate | 2018-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0b76da00f3d140a9bf12b239560dc94a2022-12-21T19:27:19ZengNature PortfolioNature Communications2041-17232018-06-019111510.1038/s41467-018-04674-yCyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cellsChristophe Chopard0Phuoc Bao Viet Tong1Petra Tóth2Malvina Schatz3Hocine Yezid4Solène Debaisieux5Clément Mettling6Antoine Gross7Martine Pugnière8Annie Tu9Jean-Marc Strub10Jean-Michel Mesnard11Nicolas Vitale12Bruno Beaumelle13IRIM, UMR 9004, Université de Montpellier-CNRSIRIM, UMR 9004, Université de Montpellier-CNRSINCI, UPR 3212 CNRS, 5 rue Blaise PascalIRIM, UMR 9004, Université de Montpellier-CNRSIRIM, UMR 9004, Université de Montpellier-CNRSIRIM, UMR 9004, Université de Montpellier-CNRSIGH, UPR 1142 CNRS, 141 Rue de la CardonilleIRIM, UMR 9004, Université de Montpellier-CNRSIRCM, INSERM U 1194, 208 Rue des ApothicairesINCI, UPR 3212 CNRS, 5 rue Blaise PascalCNRS, IPHC UMR 7178, Université de StrasbourgIRIM, UMR 9004, Université de Montpellier-CNRSINCI, UPR 3212 CNRS, 5 rue Blaise PascalIRIM, UMR 9004, Université de Montpellier-CNRSIt is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane.https://doi.org/10.1038/s41467-018-04674-y |
| spellingShingle | Christophe Chopard Phuoc Bao Viet Tong Petra Tóth Malvina Schatz Hocine Yezid Solène Debaisieux Clément Mettling Antoine Gross Martine Pugnière Annie Tu Jean-Marc Strub Jean-Michel Mesnard Nicolas Vitale Bruno Beaumelle Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells Nature Communications |
| title | Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells |
| title_full | Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells |
| title_fullStr | Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells |
| title_full_unstemmed | Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells |
| title_short | Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells |
| title_sort | cyclophilin a enables specific hiv 1 tat palmitoylation and accumulation in uninfected cells |
| url | https://doi.org/10.1038/s41467-018-04674-y |
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