Is there a relationship between HMGB1 levels and clinical conditions of patients tested positive for COVID-19?
Severe COVID-19 may be complicated by acute respiratory distress syndrome, sepsis and septic shock, which can lead to death. These life-threatening conditions are supposed to be the outcome of immune system overactivity, which causes cytokine storm syndrome and multiple organ failure. High mobility...
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| Format: | Article |
| Language: | English |
| Published: |
Society of Turaz Bilim
2022-12-01
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| Series: | Medicine Science |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=60011 |
| _version_ | 1797327817495543808 |
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| author | Nevhiz Gundogdu Mustafa Tanriverdi Hale Celikturk Mustafa Yildirim Necla Benlier Hanifi Ayhan Ozkur Hulya Cicek |
| author_facet | Nevhiz Gundogdu Mustafa Tanriverdi Hale Celikturk Mustafa Yildirim Necla Benlier Hanifi Ayhan Ozkur Hulya Cicek |
| author_sort | Nevhiz Gundogdu |
| collection | DOAJ |
| description | Severe COVID-19 may be complicated by acute respiratory distress syndrome, sepsis and septic shock, which can lead to death. These life-threatening conditions are supposed to be the outcome of immune system overactivity, which causes cytokine storm syndrome and multiple organ failure. High mobility group box-1 (HMGB1) is one of the damages associated with molecular model molecules (DAMPs), which plays a role in the pathogenesis of various inflammatory diseases and infections where many studies have been conducted. In this study, the role of HMGB1 in COVID-19 positive cases, which could be considered a potential diagnosis and treatment method, is investigated. COVID-19 patients, who were hospitalized to our clinic in Sanko University Hospital, were included in this study. Blood samples were taken from patients to measure their HMGB1 level which was then compared with their clinical severity. It is observed that HMGB1 levels rise in COVID-19 patients when compared to the control group, but the severity of the illness does not get particularly affected by their HMGB1 levels. [Med-Science 2022; 11(4.000): 1398-401] |
| first_indexed | 2024-03-08T06:42:52Z |
| format | Article |
| id | doaj.art-0b791514e06b4f4bbffdb56c565419cb |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:42:52Z |
| publishDate | 2022-12-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-0b791514e06b4f4bbffdb56c565419cb2024-02-03T08:19:15ZengSociety of Turaz BilimMedicine Science2147-06342022-12-01114139840110.5455/medscience.2022.06.14160011Is there a relationship between HMGB1 levels and clinical conditions of patients tested positive for COVID-19?Nevhiz Gundogdu0Mustafa TanriverdiHale CelikturkMustafa YildirimNecla BenlierHanifi Ayhan OzkurHulya CicekSANKO University, Faculty of Medicine, Department of Chest Diseases, Gaziantep, Turkiye SANKO University, Faculty of Medicine, Department of Infectiosu Diseases, Gaziantep, Turkiye SANKO University, Faculty of Medicine, Department of Biology, Gaziantep, Turkiye SANKO University, Faculty of Medicine, Department of Medical Oncology, Gaziantep, Turkiye SANKO University, Faculty of Medicine, Department of Pharmacology, Gaziantep, Turkiye SANKO University, Faculty of Medicine, Department of Radiology, Gaziantep, Turkiye Gaziantep University, Faculty of Medicine, Department of Biochemistry, Gaziantep, TurkiyeSevere COVID-19 may be complicated by acute respiratory distress syndrome, sepsis and septic shock, which can lead to death. These life-threatening conditions are supposed to be the outcome of immune system overactivity, which causes cytokine storm syndrome and multiple organ failure. High mobility group box-1 (HMGB1) is one of the damages associated with molecular model molecules (DAMPs), which plays a role in the pathogenesis of various inflammatory diseases and infections where many studies have been conducted. In this study, the role of HMGB1 in COVID-19 positive cases, which could be considered a potential diagnosis and treatment method, is investigated. COVID-19 patients, who were hospitalized to our clinic in Sanko University Hospital, were included in this study. Blood samples were taken from patients to measure their HMGB1 level which was then compared with their clinical severity. It is observed that HMGB1 levels rise in COVID-19 patients when compared to the control group, but the severity of the illness does not get particularly affected by their HMGB1 levels. [Med-Science 2022; 11(4.000): 1398-401]http://www.ejmanager.com/fulltextpdf.php?mno=60011covid-19hmgb1symptoms of covid-19 |
| spellingShingle | Nevhiz Gundogdu Mustafa Tanriverdi Hale Celikturk Mustafa Yildirim Necla Benlier Hanifi Ayhan Ozkur Hulya Cicek Is there a relationship between HMGB1 levels and clinical conditions of patients tested positive for COVID-19? Medicine Science covid-19 hmgb1 symptoms of covid-19 |
| title | Is there a relationship between HMGB1 levels and clinical conditions of patients tested positive for COVID-19? |
| title_full | Is there a relationship between HMGB1 levels and clinical conditions of patients tested positive for COVID-19? |
| title_fullStr | Is there a relationship between HMGB1 levels and clinical conditions of patients tested positive for COVID-19? |
| title_full_unstemmed | Is there a relationship between HMGB1 levels and clinical conditions of patients tested positive for COVID-19? |
| title_short | Is there a relationship between HMGB1 levels and clinical conditions of patients tested positive for COVID-19? |
| title_sort | is there a relationship between hmgb1 levels and clinical conditions of patients tested positive for covid 19 |
| topic | covid-19 hmgb1 symptoms of covid-19 |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=60011 |
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