Causal association between atopic dermatitis and Parkinson's disease: A bidirectional Mendelian randomization study
Abstract Background Atopic dermatitis is one of the most common skin disorders. Evidence has suggested an association between skin disorders, such as atopic dermatitis, and Parkinson's disease (PD). However, whether atopic dermatitis has a causal effect on PD remains unknown. Methods The study...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.3468 |
| _version_ | 1827308725148319744 |
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| author | Taofeng Zhou Baohao Wei Yachun Hu Xiaoming Zhou Xiaoying Cai Xiaolei Shi |
| author_facet | Taofeng Zhou Baohao Wei Yachun Hu Xiaoming Zhou Xiaoying Cai Xiaolei Shi |
| author_sort | Taofeng Zhou |
| collection | DOAJ |
| description | Abstract Background Atopic dermatitis is one of the most common skin disorders. Evidence has suggested an association between skin disorders, such as atopic dermatitis, and Parkinson's disease (PD). However, whether atopic dermatitis has a causal effect on PD remains unknown. Methods The study aimed to determine whether their association between atopic dermatitis and PD is causal, using a bidirectional two‐sample Mendelian randomization method. Genetic variants from the public genome‐wide association studies for atopic dermatitis (n = 10788 cases and 30047 controls) were selected to evaluate their causal effects on the risk of PD (33,674 cases and 449,056 controls). The inverse variance weighted (IVW) method was used as the primary analysis. Results The IVW results indicated that atopic dermatitis was associated with decreased risk of PD {fixed effects: odds ratio [OR] [95% confidence interval (CI)]: .905 [.832–.986], p = .022; OR [95% CI]: .905 [.827–.991], p = .032}. However, we failed to detect the causal effects of PD on risk of atopic dermatitis in the reverse causation analysis. Conclusion This study indicated causal association of genetically proxied atopic dermatitis with the risk of PD. Future studies are warranted to explore the underlying mechanism and investigate the targeting effect of atopic dermatitis on PD. |
| first_indexed | 2024-04-24T19:15:56Z |
| format | Article |
| id | doaj.art-0b7983e945564388b8e9a5462fea8d93 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-04-24T19:15:56Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-0b7983e945564388b8e9a5462fea8d932024-03-26T05:06:44ZengWileyBrain and Behavior2162-32792024-03-01143n/an/a10.1002/brb3.3468Causal association between atopic dermatitis and Parkinson's disease: A bidirectional Mendelian randomization studyTaofeng Zhou0Baohao Wei1Yachun Hu2Xiaoming Zhou3Xiaoying Cai4Xiaolei Shi5Department of Neurology Yijishan Hospital, Wannan Medical College Wuhu ChinaDepartment of Neurology Yijishan Hospital, Wannan Medical College Wuhu ChinaDepartment of Neurology The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou ChinaDepartment of Neurology The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou ChinaDepartment of Anesthesiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou ChinaGeriatric Neuroscience Center The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou ChinaAbstract Background Atopic dermatitis is one of the most common skin disorders. Evidence has suggested an association between skin disorders, such as atopic dermatitis, and Parkinson's disease (PD). However, whether atopic dermatitis has a causal effect on PD remains unknown. Methods The study aimed to determine whether their association between atopic dermatitis and PD is causal, using a bidirectional two‐sample Mendelian randomization method. Genetic variants from the public genome‐wide association studies for atopic dermatitis (n = 10788 cases and 30047 controls) were selected to evaluate their causal effects on the risk of PD (33,674 cases and 449,056 controls). The inverse variance weighted (IVW) method was used as the primary analysis. Results The IVW results indicated that atopic dermatitis was associated with decreased risk of PD {fixed effects: odds ratio [OR] [95% confidence interval (CI)]: .905 [.832–.986], p = .022; OR [95% CI]: .905 [.827–.991], p = .032}. However, we failed to detect the causal effects of PD on risk of atopic dermatitis in the reverse causation analysis. Conclusion This study indicated causal association of genetically proxied atopic dermatitis with the risk of PD. Future studies are warranted to explore the underlying mechanism and investigate the targeting effect of atopic dermatitis on PD.https://doi.org/10.1002/brb3.3468atopic dermatitiscausal associationMendelian randomizationParkinson's disease |
| spellingShingle | Taofeng Zhou Baohao Wei Yachun Hu Xiaoming Zhou Xiaoying Cai Xiaolei Shi Causal association between atopic dermatitis and Parkinson's disease: A bidirectional Mendelian randomization study Brain and Behavior atopic dermatitis causal association Mendelian randomization Parkinson's disease |
| title | Causal association between atopic dermatitis and Parkinson's disease: A bidirectional Mendelian randomization study |
| title_full | Causal association between atopic dermatitis and Parkinson's disease: A bidirectional Mendelian randomization study |
| title_fullStr | Causal association between atopic dermatitis and Parkinson's disease: A bidirectional Mendelian randomization study |
| title_full_unstemmed | Causal association between atopic dermatitis and Parkinson's disease: A bidirectional Mendelian randomization study |
| title_short | Causal association between atopic dermatitis and Parkinson's disease: A bidirectional Mendelian randomization study |
| title_sort | causal association between atopic dermatitis and parkinson s disease a bidirectional mendelian randomization study |
| topic | atopic dermatitis causal association Mendelian randomization Parkinson's disease |
| url | https://doi.org/10.1002/brb3.3468 |
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