Whole Body Vibration Improves Brain and Musculoskeletal Health by Modulating the Expression of Tissue-Specific Markers: FNDC5 as a Key Regulator of Vibration Adaptations
Whole body vibration (WBV) is well known to exert beneficial effects on multiple tissues, improving synaptic transmission, muscle mass, bone quality, and reducing anxiety and depressive behavior. However, the underlying molecular mechanisms are not yet fully understood, and organs and tissues may re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/18/10388 |
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| author | Ida Cariati Roberto Bonanni Gabriele Pallone Cristian Romagnoli Anna Maria Rinaldi Giuseppe Annino Giovanna D’Arcangelo Virginia Tancredi |
| author_facet | Ida Cariati Roberto Bonanni Gabriele Pallone Cristian Romagnoli Anna Maria Rinaldi Giuseppe Annino Giovanna D’Arcangelo Virginia Tancredi |
| author_sort | Ida Cariati |
| collection | DOAJ |
| description | Whole body vibration (WBV) is well known to exert beneficial effects on multiple tissues, improving synaptic transmission, muscle mass, bone quality, and reducing anxiety and depressive behavior. However, the underlying molecular mechanisms are not yet fully understood, and organs and tissues may respond differently to the vibratory stimulus depending on multiple factors. Therefore, we investigated the WBV effects on the brain and musculoskeletal tissue of 4-month-old young mice, evaluating synaptic plasticity by electrophysiological recordings and tissue organization by histology and histomorphometric analysis. Specifically, WBV protocols were characterized by the same vibration frequency (45 Hz), but different in vibration exposure time (five series of 3 min for the B protocol and three series of 2 min and 30 s for the C protocol) and recovery time between two vibration sessions (1 min for the B protocol and 2 min and 30 s for the C protocol). In addition, immunohistochemistry was conducted to evaluate the expression of fibronectin type III domain-containing protein 5 (FNDC5), as well as that of tissue-specific markers, such as brain-derived neurotrophic factor (BDNF) in brain, myostatin in muscle and collagen I (COL-1) in bone. Our results suggest that the WBV effects depend closely on the type of protocol used and support the hypothesis that different organs or tissues have different susceptibility to vibration. Further studies will be needed to deepen our knowledge of physiological adaptations to vibration and develop customized WBV protocols to improve and preserve cognitive and motor functions. |
| first_indexed | 2024-03-09T23:47:21Z |
| format | Article |
| id | doaj.art-0b7aebf93234439c8943b1dac7ea1f72 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:47:21Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0b7aebf93234439c8943b1dac7ea1f722023-11-23T16:40:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123181038810.3390/ijms231810388Whole Body Vibration Improves Brain and Musculoskeletal Health by Modulating the Expression of Tissue-Specific Markers: FNDC5 as a Key Regulator of Vibration AdaptationsIda Cariati0Roberto Bonanni1Gabriele Pallone2Cristian Romagnoli3Anna Maria Rinaldi4Giuseppe Annino5Giovanna D’Arcangelo6Virginia Tancredi7Department of Clinical Sciences and Translational Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Clinical Sciences and Translational Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Industrial Engineering, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyWhole body vibration (WBV) is well known to exert beneficial effects on multiple tissues, improving synaptic transmission, muscle mass, bone quality, and reducing anxiety and depressive behavior. However, the underlying molecular mechanisms are not yet fully understood, and organs and tissues may respond differently to the vibratory stimulus depending on multiple factors. Therefore, we investigated the WBV effects on the brain and musculoskeletal tissue of 4-month-old young mice, evaluating synaptic plasticity by electrophysiological recordings and tissue organization by histology and histomorphometric analysis. Specifically, WBV protocols were characterized by the same vibration frequency (45 Hz), but different in vibration exposure time (five series of 3 min for the B protocol and three series of 2 min and 30 s for the C protocol) and recovery time between two vibration sessions (1 min for the B protocol and 2 min and 30 s for the C protocol). In addition, immunohistochemistry was conducted to evaluate the expression of fibronectin type III domain-containing protein 5 (FNDC5), as well as that of tissue-specific markers, such as brain-derived neurotrophic factor (BDNF) in brain, myostatin in muscle and collagen I (COL-1) in bone. Our results suggest that the WBV effects depend closely on the type of protocol used and support the hypothesis that different organs or tissues have different susceptibility to vibration. Further studies will be needed to deepen our knowledge of physiological adaptations to vibration and develop customized WBV protocols to improve and preserve cognitive and motor functions.https://www.mdpi.com/1422-0067/23/18/10388whole body vibrationsynaptic plasticityhippocampuscerebellummusculoskeletal systemFNDC5 |
| spellingShingle | Ida Cariati Roberto Bonanni Gabriele Pallone Cristian Romagnoli Anna Maria Rinaldi Giuseppe Annino Giovanna D’Arcangelo Virginia Tancredi Whole Body Vibration Improves Brain and Musculoskeletal Health by Modulating the Expression of Tissue-Specific Markers: FNDC5 as a Key Regulator of Vibration Adaptations International Journal of Molecular Sciences whole body vibration synaptic plasticity hippocampus cerebellum musculoskeletal system FNDC5 |
| title | Whole Body Vibration Improves Brain and Musculoskeletal Health by Modulating the Expression of Tissue-Specific Markers: FNDC5 as a Key Regulator of Vibration Adaptations |
| title_full | Whole Body Vibration Improves Brain and Musculoskeletal Health by Modulating the Expression of Tissue-Specific Markers: FNDC5 as a Key Regulator of Vibration Adaptations |
| title_fullStr | Whole Body Vibration Improves Brain and Musculoskeletal Health by Modulating the Expression of Tissue-Specific Markers: FNDC5 as a Key Regulator of Vibration Adaptations |
| title_full_unstemmed | Whole Body Vibration Improves Brain and Musculoskeletal Health by Modulating the Expression of Tissue-Specific Markers: FNDC5 as a Key Regulator of Vibration Adaptations |
| title_short | Whole Body Vibration Improves Brain and Musculoskeletal Health by Modulating the Expression of Tissue-Specific Markers: FNDC5 as a Key Regulator of Vibration Adaptations |
| title_sort | whole body vibration improves brain and musculoskeletal health by modulating the expression of tissue specific markers fndc5 as a key regulator of vibration adaptations |
| topic | whole body vibration synaptic plasticity hippocampus cerebellum musculoskeletal system FNDC5 |
| url | https://www.mdpi.com/1422-0067/23/18/10388 |
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